Lexicon Pharmaceuticals, Inc. (LXRX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

189,447,826Shares Outstanding

3,289,309Shares held by institutions

$4,341,888Value of institutional holdings

101.00%Institutional ownership %

32.26%Shares Changed QoQ

125No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Recent 13F filings as of December 2025 show that 119 institutional investors hold a position in Lexicon Pharmaceuticals, Inc. (NASDAQ:LXRX).

The collective stake of institutional investors in Lexicon Pharmaceuticals moved to 81.4% in December 2025, a shift up from the 81.2% reported for September 2025.
Quarterly data indicates a 2.63% shift in institutional share volume, and the annual owner count reflects a decrease of 4.03%.
During the quarter, 50 institutions bought more Lexicon Pharmaceuticals shares, 36 sold shares, and 33 of the 119 total investors held their position steady.
This class of investors increased its holdings in Lexicon Pharmaceuticals to 259.69Mn shares for the 13F-cycle ending December 2025, up by 6.67Mn shares quarter on quarter, and down 37.87Mn shares year over year.
The top institutional stake in Lexicon Pharmaceuticals as of December 31, 2025 belongs to Artal Group S.A., which owns 136.18Mn shares, or 42.66% of the company.
Among the most significant buyers of Lexicon Pharmaceuticals during December 2025 were UBS Group AG (2.65Mn), JANE STREET GROUP, LLC (1.36Mn), MARSHALL WACE, LLP (1.26Mn), MILLENNIUM MANAGEMENT LLC (991.07K), Ishara Investments LP (880.00K).
Leading sellers of Lexicon Pharmaceuticals stock in December 2025 included CITADEL ADVISORS LLC (923.05K), FMR LLC (845.54K), Schonfeld Strategic Advisors LLC (812.52K), ROYAL BANK OF CANADA (715.67K), CIBC Private Wealth Group LLC (450.26K).
The top 10 institutional holders of Lexicon Pharmaceuticals for the quarter ending December 2025 included Artal Group S.A. (136.18Mn), Siren, L.L.C. (38.92Mn), FMR LLC (37.83Mn), VANGUARD GROUP INC (9.61Mn), MILLENNIUM MANAGEMENT LLC (4.82Mn), BlackRock, Inc. (3.19Mn), UBS Group AG (3.01Mn), Sessa Capital IM, L.P. (3.00Mn), GEODE CAPITAL MANAGEMENT, LLC (2.50Mn), CIBC Private Wealth Group LLC (1.95Mn).

119 Institutional Holders

3,289,309 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Artal Group S.A.	31 Dec, 2025	136,180,481	0	0.00%	$156,607,553.00
Siren, L.L.C.	31 Dec, 2025	38,918,903	0	0.00%	$44,756,738.00
FMR LLC	31 Dec, 2025	37,834,207	-845,541	-2.19%	$43,509,338.00
VANGUARD GROUP INC	31 Dec, 2025	9,606,549	84,675	0.89%	$11,047,532.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	4,821,733	991,073	25.87%	$5,544,993.00
BlackRock, Inc.	31 Dec, 2025	3,192,448	-202,524	-5.97%	$3,671,316.00
UBS Group AG	31 Dec, 2025	3,007,237	2,654,315	752.10%	$3,458,322.00
Sessa Capital IM, L.P.	31 Dec, 2025	3,000,000	0	0.00%	$3,450,000.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	2,500,022	102,099	4.26%	$2,876,410.00
CIBC Private Wealth Group LLC	31 Dec, 2025	1,950,000	-450,257	-18.76%	$2,242,500.00
JANE STREET GROUP, LLC	31 Dec, 2025	1,828,404	1,360,574	290.83%	$2,102,665.00
CITADEL ADVISORS LLC	31 Dec, 2025	1,710,975	-923,052	-35.04%	$1,967,621.00
MARSHALL WACE, LLP	31 Dec, 2025	1,262,367	1,262,367	0.00%	$1,451,722.00
SUSQUEHANNA INTERNATIONAL GROUP, LLP	31 Dec, 2025	1,207,242	245,182	25.49%	$1,388,329.00
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	31 Dec, 2025	1,055,123	-89,509	-7.82%	$1,213,391.00
GSA CAPITAL PARTNERS LLP	31 Dec, 2025	996,235	-206,671	-17.18%	$1,146.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	921,204	861,857	1,452.23%	$1,059,385.00
Hennion & Walsh Asset Management, Inc.	31 Dec, 2025	901,222	122,010	15.66%	$1,036,405.00
STATE STREET CORP	31 Dec, 2025	884,738	4,617	0.52%	$1,017,449.00
Ishara Investments LP	31 Dec, 2025	880,000	880,000	0.00%	$1,012,000.00

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