Lexicon Pharmaceuticals, Inc. (LXRX) Institutional Ownership

Ownership Summary

Lexicon Pharmaceuticals, Inc. (NASDAQ:LXRX) currently has 123 active institutional owners and shareholders as of today (September 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

• Lexicon Pharmaceuticals saw its institutional ownership percentage rose to 71.3% in September 2025 from 70.6% in June 2025.
• Quarterly data indicates a 1.24% shift in institutional share volume, and the annual owner count reflects a decrease of 9.56%.
• The latest 13F cycle for Lexicon Pharmaceuticals reveals that of 123 total investors, 42 funds grew their exposure, whereas 45 reduced theirs and 36 made no changes.
• Collectively, institutional investors increased their stake in Lexicon Pharmaceuticals to 259.22Mn shares as of September 2025, a change that is up by 3.16Mn shares quarter on quarter and down 29.19Mn shares year over year.
• As of September 30, 2025, Artal Group S.A. held Lexicon Pharmaceuticals's largest shareholding position with over 136.18Mn shares, representing 37.47% of total outstanding shares.
• Among the most significant buyers of Lexicon Pharmaceuticals during September 2025 were CITADEL ADVISORS LLC (2.63Mn), CIBC Bancorp USA Inc. (2.40Mn), MILLENNIUM MANAGEMENT LLC (2.19Mn), Caption Management, LLC (1.95Mn), VANGUARD GROUP INC (670.84K).
• Leading sellers of Lexicon Pharmaceuticals stock in September 2025 included Schonfeld Strategic Advisors LLC (3.75Mn), GSA CAPITAL PARTNERS LLP (1.63Mn), AQR CAPITAL MANAGEMENT LLC (1.10Mn), ACADIAN ASSET MANAGEMENT LLC (536.78K), HRT FINANCIAL LP (442.02K).
• The top 10 institutional holders of Lexicon Pharmaceuticals for the quarter ending September 2025 included Artal Group S.A. (136.18Mn), Siren, L.L.C. (38.92Mn), FMR LLC (38.68Mn), VANGUARD GROUP INC (9.52Mn), MILLENNIUM MANAGEMENT LLC (3.83Mn), BlackRock, Inc. (3.39Mn), Sessa Capital IM, L.P. (3.00Mn), CITADEL ADVISORS LLC (2.63Mn), CIBC Private Wealth Group LLC (2.40Mn), CIBC Bancorp USA Inc. (2.40Mn).