Xilio Therapeutics (XLO) Operating Income (2020 - 2026)

Xilio Therapeutics (XLO) reported Operating Income of -$14.1 million for Q1 2026, down 1.88% on a YoY basis from -$14.4 million in Q1 2025, and down 19.23% sequentially from -$11.8 million in Q4 2025.

Xilio Therapeutics (XLO) Operating Income (2020 - 2026) Analysis & Trends

Xilio Therapeutics (XLO) has 7 years of Operating Income data on file, last reported at -$14.1 million in Q1 2026.

  • For the quarter ending Q1 2026, Operating Income fell 1.88% year-over-year to -$14.1 million; the trailing twelve-month figure through Mar 2026 stood at -$42.2 million (up 25.82% YoY), and the FY2025 full-year result was -$42.0 million, up 30.7% from the prior year.
  • Operating Income eased to -$14.1 million in Q1 2026, from -$11.8 million in the prior quarter.
  • In the past five years, Operating Income ranged from a high of -$1.9 million in Q3 2025 to a low of -$24.6 million in Q2 2022.
  • A 5-year average of -$16.8 million and a median of -$17.4 million in 2023 frame the typical range for Operating Income.
  • Across the five-year window, Operating Income decreased 28.47% in 2022 and surged 86.93% in 2025, its largest moves.
  • Tracing XLO's Operating Income over 5 years: stood at -$23.2 million in 2022, then climbed by 21.74% to -$18.1 million in 2023, then increased by 24.83% to -$13.6 million in 2024, then increased by 13.16% to -$11.8 million in 2025, then decreased by 19.23% to -$14.1 million in 2026.
  • Business Quant data shows XLO's Operating Income at -$14.1 million in Q1 2026, -$11.8 million in Q4 2025, and -$1.9 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Oculis Holding AG 66,741.39 Bn 66,741.11 Bn - -27.75 Mn
2 Nanobiotix 1,935.05 Bn 1,934.98 Bn - -
3 Akari Therapeutics 1,045.06 Bn 1,045.06 Bn - -15.76 Mn
4 BeOne Medicines 468.98 Bn 464.19 Bn 1.35 Bn 249.90 Mn
5 Vertex Pharmaceuticals 123.24 Bn 115.99 Bn 2.59 Bn 1.14 Bn
6 Regeneron Pharmaceuticals 70.45 Bn 61.70 Bn 3.31 Bn 642.90 Mn
7 Belite Bio 63.04 Bn 63.04 Bn - -32.68 Mn
8 Argenx Se 55.79 Bn 50.60 Bn 1.41 Bn 493.00 Mn
9 Alnylam Pharmaceuticals 37.79 Bn 34.78 Bn 959.66 Mn 268.64 Mn
10 Xilio Therapeutics 147.13 Mn -3.17 Mn - -14.11 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -14.11 Mn
Dec 31, 2025 -11.84 Mn
Sep 30, 2025 -1.93 Mn
Jun 30, 2025 -14.37 Mn
Mar 31, 2025 -13.85 Mn
Dec 31, 2024 -13.63 Mn
Sep 30, 2024 -14.76 Mn
Jun 30, 2024 -14.70 Mn
Mar 31, 2024 -17.49 Mn
Dec 31, 2023 -18.13 Mn
Sep 30, 2023 -17.36 Mn
Jun 30, 2023 -20.12 Mn
Mar 31, 2023 -23.53 Mn
Dec 31, 2022 -23.17 Mn
Sep 30, 2022 -20.21 Mn
Jun 30, 2022 -24.55 Mn
Mar 31, 2022 -21.22 Mn
Dec 31, 2021 -19.56 Mn
Sep 30, 2021 -15.96 Mn
Jun 30, 2021 -23.01 Mn