Xilio Therapeutics (XLO) Net Margin (2024 - 2026)

Xilio Therapeutics (XLO) reported Net Margin of 111.73% for Q1 2026, up 36302.0% on a YoY basis from N/an in Q1 2025, and down 28.89% sequentially from 86.68% in Q4 2025.

Xilio Therapeutics (XLO) Net Margin (2024 - 2026) Analysis & Trends

Xilio Therapeutics (XLO) has 3 years of Net Margin data on file, last reported at 111.73% in Q1 2026.

  • For the quarter ending Q1 2026, Net Margin rose 36302.0% year-over-year to 111.73%; the trailing twelve-month figure through Mar 2026 stood at 79.27% (up 54140.0% YoY), and the FY2025 full-year result was 382.53%, up 234609.0% from the prior year.
  • Net Margin fell to 111.73% in Q1 2026, from 86.68% in the prior quarter.
  • In the past five years, Net Margin ranged from a high of 10.47% in Q3 2025 to a low of 806.9% in Q4 2024.
  • A 3-year average of 369.59% and a median of 326.47% in 2025 frame the typical range for Net Margin.
  • Across the five-year window, Net Margin soared 72022 bps in 2025 and jumped 36302 bps in 2026, its largest moves.
  • Tracing XLO's Net Margin over 3 years: stood at 806.9% in 2024, then surged by 89 bps to 86.68% in 2025, then decreased by 29 bps to 111.73% in 2026.
  • Business Quant data shows XLO's Net Margin at 111.73% in Q1 2026, 86.68% in Q4 2025, and 10.47% in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Net Margin (Qtr)
1 Oculis Holding AG 66,621.14 Bn 66,620.85 Bn - -
2 Nanobiotix 1,915.18 Bn 1,915.11 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -
4 BeOne Medicines 471.27 Bn 466.48 Bn 1.35 Bn 15.02%
5 Vertex Pharmaceuticals 121.81 Bn 114.57 Bn 2.59 Bn 34.53%
6 Regeneron Pharmaceuticals 69.58 Bn 60.82 Bn 3.31 Bn 20.17%
7 Belite Bio 62.72 Bn 62.72 Bn - -
8 Argenx Se 55.51 Bn 50.33 Bn 1.41 Bn 30.33%
9 Revolution Medicines 37.35 Bn 37.35 Bn - -
10 Xilio Therapeutics 148.60 Mn -1.70 Mn - -111.73%

Historic Data

Download Data
DateValue
Mar 31, 2026 -111.73%
Dec 31, 2025 -86.68%
Sep 30, 2025 -10.47%
Jun 30, 2025 -178.19%
Mar 31, 2025 -474.74%
Dec 31, 2024 -806.90%
Sep 30, 2024 -656.69%
Jun 30, 2024 -631.27%