Xilio Therapeutics (XLO) Net Margin (2024 - 2026)
Xilio Therapeutics (XLO) posted Net Margin of 111.73% for Q1 2026, down 28.89% sequentially from 86.68% in Q4 2025, and up 36302.0% YoY from N/an in Q1 2025.
Xilio Therapeutics (XLO) Net Margin (2024 - 2026) Analysis & Trends
Xilio Therapeutics has reported Net Margin for 3 years, with the latest figure at 111.73% in Q1 2026.
- Quarterly Net Margin rose 36302.0% year-over-year to 111.73% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 79.27% (up 54140.0% YoY) and the FY2025 annual result came in at 382.53%, up 234609.0% from the prior year.
- Net Margin fell to 111.73% in Q1 2026 per XLO's latest filing, from 86.68% in the prior quarter.
- Over five years, Net Margin peaked at 10.47% in Q3 2025 and troughed at 806.9% in Q4 2024.
- A 3-year average of 369.59% and a median of 326.47% in 2025 frame the typical range for Net Margin.
- The sharpest annual moves came in 2025 and 2026: Net Margin surged 72022 bps in 2025, then soared 36302 bps in 2026.
- Over 3 years, Net Margin stood at 806.9% in 2024, then surged by 89 bps to 86.68% in 2025, then declined by 29 bps to 111.73% in 2026.
- According to Business Quant data, Net Margin over the past three periods registered 111.73%, 86.68%, and 10.47% for Q1 2026, Q4 2025, and Q3 2025 respectively.
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| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 139.13 Bn | 131.28 Bn | 2.84 Bn | 32.99% |
| 2 | Regeneron Pharmaceuticals | 85.77 Bn | 77.77 Bn | 3.93 Bn | 30.23% |
| 3 | Argenx Se | 64.64 Bn | 59.46 Bn | 1.37 Bn | 31.16% |
| 4 | Moderna | 58.29 Bn | 53.16 Bn | 52.00 Mn | -539.31% |
| 5 | BeOne Medicines | 41.92 Bn | 36.82 Bn | 1.53 Bn | 13.90% |
| 6 | Alnylam Pharmaceuticals | 31.58 Bn | 28.28 Bn | 992.69 Mn | 12.74% |
| 7 | BioNTech SE | 28.12 Bn | 9.73 Bn | 668.28 Mn | -16.51% |
| 8 | Insmed | 27.39 Bn | 26.22 Bn | 358.27 Mn | -3.12% |
| 9 | Royalty Pharma | 27.27 Bn | 26.43 Bn | - | 12.09% |
| 10 | Xilio Therapeutics | 178.33 Mn | 42.29 Mn | - | -18.68% |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | -19.37% |
| Mar 31, 2026 | -111.73% |
| Dec 31, 2025 | -86.68% |
| Sep 30, 2025 | -10.47% |
| Jun 30, 2025 | -178.19% |
| Mar 31, 2025 | -474.74% |
| Dec 31, 2024 | -806.90% |
| Sep 30, 2024 | -656.69% |
| Jun 30, 2024 | -631.27% |