Xilio Therapeutics (XLO) Free Cash Flow (2020 - 2026)

Xilio Therapeutics (XLO) reported Free Cash Flow of -$22.9 million for Q1 2026, down 179.83% on a YoY basis from $28.7 million in Q1 2025, and down 1034.74% sequentially from -$2.0 million in Q4 2025.

Xilio Therapeutics (XLO) Free Cash Flow (2020 - 2026) Analysis & Trends

Xilio Therapeutics (XLO) has 7 years of Free Cash Flow data on file, last reported at -$22.9 million in Q1 2026.

  • For the quarter ending Q1 2026, Free Cash Flow fell 179.83% year-over-year to -$22.9 million; the trailing twelve-month figure through Mar 2026 stood at -$57.0 million (down 374.2% YoY), and the FY2025 full-year result was -$5.4 million, up 70.48% from the prior year.
  • Free Cash Flow declined to -$22.9 million in Q1 2026, from -$2.0 million in the prior quarter.
  • In the past five years, Free Cash Flow ranged from a high of $28.7 million in Q1 2025 to a low of -$25.4 million in Q1 2023.
  • A 5-year average of -$11.3 million and a median of -$14.6 million in 2025 frame the typical range for Free Cash Flow.
  • Across the five-year window, Free Cash Flow surged 372.6% in 2025 and tumbled 179.83% in 2026, its largest moves.
  • Tracing XLO's Free Cash Flow over 5 years: stood at -$16.9 million in 2022, then climbed by 20.48% to -$13.4 million in 2023, then dropped by 5.48% to -$14.2 million in 2024, then soared by 85.75% to -$2.0 million in 2025, then sank by 1034.74% to -$22.9 million in 2026.
  • Business Quant data shows XLO's Free Cash Flow at -$22.9 million in Q1 2026, -$2.0 million in Q4 2025, and -$17.5 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Free Cash Flow (Qtr)
1 Oculis Holding AG 66,621.14 Bn 66,620.85 Bn - -19.58 Mn
2 Nanobiotix 1,915.18 Bn 1,915.11 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -2.49 Mn
4 BeOne Medicines 471.27 Bn 466.48 Bn 1.35 Bn 158.09 Mn
5 Vertex Pharmaceuticals 121.81 Bn 114.57 Bn 2.59 Bn 1.29 Bn
6 Regeneron Pharmaceuticals 69.58 Bn 60.82 Bn 3.31 Bn 848.30 Mn
7 Belite Bio 62.72 Bn 62.72 Bn - -
8 Argenx Se 55.51 Bn 50.33 Bn 1.41 Bn -
9 Revolution Medicines 37.35 Bn 37.35 Bn - -354.95 Mn
10 Xilio Therapeutics 148.60 Mn -1.70 Mn - -22.90 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -22.90 Mn
Mar 31, 2026 -22.90 Mn
Dec 31, 2025 -2.02 Mn
Dec 31, 2025 -2.02 Mn
Sep 30, 2025 -17.50 Mn
Sep 30, 2025 -17.50 Mn
Jun 30, 2025 -14.61 Mn
Jun 30, 2025 -14.61 Mn
Mar 31, 2025 28.69 Mn
Mar 31, 2025 28.69 Mn
Dec 31, 2024 -14.16 Mn
Dec 31, 2024 -14.16 Mn
Sep 30, 2024 -13.68 Mn
Sep 30, 2024 -13.68 Mn
Jun 30, 2024 19.95 Mn
Jun 30, 2024 19.95 Mn
Mar 31, 2024 -10.52 Mn
Mar 31, 2024 -10.52 Mn
Dec 31, 2023 -13.43 Mn
Dec 31, 2023 -13.43 Mn