Xilio Therapeutics (XLO) Free Cash Flow (2020 - 2026)

Xilio Therapeutics' (XLO) quarterly Free Cash Flow came in at -$22.9 million in Q1 2026, down 179.83% year-on-year from $28.7 million in Q1 2025, and down 994.08% quarter-over-quarter from -$2.1 million in Q4 2025.

Xilio Therapeutics (XLO) Free Cash Flow (2020 - 2026) Analysis & Trends

Xilio Therapeutics has disclosed Free Cash Flow across 7 years of filings, most recently posting -$22.9 million for Q1 2026.

  • Free Cash Flow for Q1 2026 came in at -$22.9 million, down 179.83% year-over-year; the trailing twelve-month figure through Mar 2026 was -$57.1 million (down 374.56% YoY), and the FY2025 annual result was -$5.5 million, up 70.08% from the prior year.
  • Free Cash Flow came in at -$22.9 million for Q1 2026 at Xilio Therapeutics, down from -$2.1 million in the prior quarter.
  • In the past five years, Free Cash Flow ranged from a high of $28.7 million in Q1 2025 to a low of -$25.4 million in Q1 2023.
  • The 5-year median for Free Cash Flow is -$14.6 million (2025), against an average of -$11.3 million.
  • Across the five-year window, Free Cash Flow surged 372.6% in 2025 and sank 179.83% in 2026, its largest moves.
  • Xilio Therapeutics' Free Cash Flow stood at -$17.9 million in 2022, then increased by 24.87% to -$13.4 million in 2023, then declined by 5.48% to -$14.2 million in 2024, then surged by 85.22% to -$2.1 million in 2025, then sank by 994.08% to -$22.9 million in 2026.
  • The last three Free Cash Flow figures came in at -$22.9 million (Q1 2026), -$2.1 million (Q4 2025), and -$17.5 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Free Cash Flow (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -1.67 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -12.20 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -2.49 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.29 Bn
9 Abivax 91.96 Bn 91.96 Bn - 63,220.27
10 Xilio Therapeutics 144.35 Mn -5.95 Mn - -22.90 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -22.90 Mn
Mar 31, 2026 -22.90 Mn
Dec 31, 2025 -2.09 Mn
Dec 31, 2025 -2.09 Mn
Sep 30, 2025 -17.50 Mn
Sep 30, 2025 -17.50 Mn
Jun 30, 2025 -14.61 Mn
Jun 30, 2025 -14.61 Mn
Mar 31, 2025 28.69 Mn
Mar 31, 2025 28.69 Mn
Dec 31, 2024 -14.16 Mn
Dec 31, 2024 -14.16 Mn
Sep 30, 2024 -13.68 Mn
Sep 30, 2024 -13.68 Mn
Jun 30, 2024 19.95 Mn
Jun 30, 2024 19.95 Mn
Mar 31, 2024 -10.52 Mn
Mar 31, 2024 -10.52 Mn
Dec 31, 2023 -13.43 Mn
Dec 31, 2023 -13.43 Mn