Xilio Therapeutics (XLO) FCF Margin (2024 - 2026)

Xilio Therapeutics (XLO) reported FCF Margin of 181.05% for Q1 2026, down 116009.0% on a YoY basis from N/an in Q1 2025, and down 1127.86% sequentially from 14.74% in Q4 2025.

Xilio Therapeutics (XLO) FCF Margin (2024 - 2026) Analysis & Trends

Xilio Therapeutics (XLO) has 3 years of FCF Margin data on file, last reported at 181.05% in Q1 2026.

  • For the quarter ending Q1 2026, FCF Margin fell 116009.0% year-over-year to 181.05%; the trailing twelve-month figure through Mar 2026 stood at 106.61% (down 33084.0% YoY), and the FY2025 full-year result was 12.42%, up 27784.0% from the prior year.
  • FCF Margin fell to 181.05% in Q1 2026, from 14.74% in the prior quarter.
  • In the past five years, FCF Margin ranged from a high of 979.04% in Q1 2025 to a low of 821.52% in Q4 2024.
  • A 3-year average of 8.59% and a median of 136.23% in 2025 frame the typical range for FCF Margin.
  • Across the five-year window, FCF Margin jumped 80677 bps in 2025 and tumbled 116009 bps in 2026, its largest moves.
  • Tracing XLO's FCF Margin over 3 years: stood at 821.52% in 2024, then jumped by 98 bps to 14.74% in 2025, then sank by 1128 bps to 181.05% in 2026.
  • Business Quant data shows XLO's FCF Margin at 181.05% in Q1 2026, 14.74% in Q4 2025, and 91.76% in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) FCF Margin (Qtr)
1 Oculis Holding AG 66,621.14 Bn 66,620.85 Bn - -
2 Nanobiotix 1,915.18 Bn 1,915.11 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -
4 BeOne Medicines 471.27 Bn 466.48 Bn 1.35 Bn 10.45%
5 Vertex Pharmaceuticals 121.81 Bn 114.57 Bn 2.59 Bn 43.35%
6 Regeneron Pharmaceuticals 69.58 Bn 60.82 Bn 3.31 Bn 23.53%
7 Belite Bio 62.72 Bn 62.72 Bn - -
8 Argenx Se 55.51 Bn 50.33 Bn 1.41 Bn -
9 Revolution Medicines 37.35 Bn 37.35 Bn - -
10 Xilio Therapeutics 148.60 Mn -1.70 Mn - -181.05%

Historic Data

Download Data
DateValue
Mar 31, 2026 -181.05%
Dec 31, 2025 -14.74%
Sep 30, 2025 -91.76%
Jun 30, 2025 -180.70%
Mar 31, 2025 979.04%
Dec 31, 2024 -821.52%
Sep 30, 2024 -604.55%
Jun 30, 2024 846.54%