Xilio Therapeutics (XLO) EBITDA Margin (2024 - 2026)
Xilio Therapeutics' (XLO) quarterly EBITDA Margin came in at 75.34% in Q1 2026, up 37739.0% year-on-year from N/an in Q1 2025, and down 199.53% quarter-over-quarter from 75.7% in Q4 2025.
Xilio Therapeutics (XLO) EBITDA Margin (2024 - 2026) Analysis & Trends
Xilio Therapeutics has disclosed EBITDA Margin across 3 years of filings, most recently posting 75.34% for Q1 2026.
- EBITDA Margin for Q1 2026 came in at 75.34%, up 37739.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 58.52% (up 52702.0% YoY), and the FY2025 annual result was 80.05%, up 83800.0% from the prior year.
- EBITDA Margin came in at 75.34% for Q1 2026 at Xilio Therapeutics, down from 75.7% in the prior quarter.
- In the past five years, EBITDA Margin ranged from a high of 75.7% in Q4 2025 to a low of 759.45% in Q4 2024.
- The 3-year median for EBITDA Margin is 324.36% (2025), against an average of 337.95%.
- Across the five-year window, EBITDA Margin surged 83515 bps in 2025 and soared 37739 bps in 2026, its largest moves.
- Xilio Therapeutics' EBITDA Margin stood at 759.45% in 2024, then soared by 110 bps to 75.7% in 2025, then slumped by 200 bps to 75.34% in 2026.
- The last three EBITDA Margin figures came in at 75.34% (Q1 2026), 75.7% (Q4 2025), and 85.42% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | - |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -6.43% |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | - |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 38.10% |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | - |
| 10 | Xilio Therapeutics | 144.35 Mn | -5.95 Mn | - | -75.34% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -75.34% |
| Dec 31, 2025 | 75.70% |
| Sep 30, 2025 | -85.42% |
| Jun 30, 2025 | -195.99% |
| Mar 31, 2025 | -452.73% |
| Dec 31, 2024 | -759.45% |
| Sep 30, 2024 | -619.53% |
| Jun 30, 2024 | -590.79% |