Xilio Therapeutics (XLO) EBITDA Margin (2024 - 2026)

Xilio Therapeutics' (XLO) quarterly EBITDA Margin came in at 75.34% in Q1 2026, up 37739.0% year-on-year from N/an in Q1 2025, and down 199.53% quarter-over-quarter from 75.7% in Q4 2025.

Xilio Therapeutics (XLO) EBITDA Margin (2024 - 2026) Analysis & Trends

Xilio Therapeutics has disclosed EBITDA Margin across 3 years of filings, most recently posting 75.34% for Q1 2026.

  • EBITDA Margin for Q1 2026 came in at 75.34%, up 37739.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 58.52% (up 52702.0% YoY), and the FY2025 annual result was 80.05%, up 83800.0% from the prior year.
  • EBITDA Margin came in at 75.34% for Q1 2026 at Xilio Therapeutics, down from 75.7% in the prior quarter.
  • In the past five years, EBITDA Margin ranged from a high of 75.7% in Q4 2025 to a low of 759.45% in Q4 2024.
  • The 3-year median for EBITDA Margin is 324.36% (2025), against an average of 337.95%.
  • Across the five-year window, EBITDA Margin surged 83515 bps in 2025 and soared 37739 bps in 2026, its largest moves.
  • Xilio Therapeutics' EBITDA Margin stood at 759.45% in 2024, then soared by 110 bps to 75.7% in 2025, then slumped by 200 bps to 75.34% in 2026.
  • The last three EBITDA Margin figures came in at 75.34% (Q1 2026), 75.7% (Q4 2025), and 85.42% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA Margin (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -6.43%
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 38.10%
9 Abivax 91.96 Bn 91.96 Bn - -
10 Xilio Therapeutics 144.35 Mn -5.95 Mn - -75.34%

Historic Data

Download Data
DateValue
Mar 31, 2026 -75.34%
Dec 31, 2025 75.70%
Sep 30, 2025 -85.42%
Jun 30, 2025 -195.99%
Mar 31, 2025 -452.73%
Dec 31, 2024 -759.45%
Sep 30, 2024 -619.53%
Jun 30, 2024 -590.79%