Xilio Therapeutics (XLO) EBITDA (2020 - 2026)
Xilio Therapeutics' (XLO) quarterly EBITDA came in at -$9.5 million in Q1 2026, up 28.16% year-on-year from -$7.4 million in Q1 2025, and down 191.98% quarter-over-quarter from $10.4 million in Q4 2025.
Xilio Therapeutics (XLO) EBITDA (2020 - 2026) Analysis & Trends
Xilio Therapeutics has disclosed EBITDA across 7 years of filings, most recently posting -$9.5 million for Q1 2026.
- EBITDA for Q1 2026 came in at -$9.5 million, up 28.16% year-over-year; the trailing twelve-month figure through Mar 2026 was -$31.3 million (up 42.36% YoY), and the FY2025 annual result was -$35.0 million, up 39.84% from the prior year.
- EBITDA came in at -$9.5 million for Q1 2026 at Xilio Therapeutics, down from $10.4 million in the prior quarter.
- In the past five years, EBITDA ranged from a high of $10.4 million in Q4 2025 to a low of -$24.6 million in Q2 2022.
- The 5-year median for EBITDA is -$16.7 million (2023), against an average of -$15.7 million.
- Across the five-year window, EBITDA declined 28.12% in 2022 and surged 179.13% in 2025, its largest moves.
- Xilio Therapeutics' EBITDA stood at -$22.5 million in 2022, then climbed by 21.41% to -$17.7 million in 2023, then grew by 25.84% to -$13.1 million in 2024, then soared by 179.13% to $10.4 million in 2025, then tumbled by 191.98% to -$9.5 million in 2026.
- The last three EBITDA figures came in at -$9.5 million (Q1 2026), $10.4 million (Q4 2025), and -$16.3 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | -26.92 Mn |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | -13.63 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -19.70 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | -3.82 Mn |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -14.44 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | -752,618.00 |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 1.14 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -65.83 Mn |
| 10 | Xilio Therapeutics | 144.35 Mn | -5.95 Mn | - | -9.53 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -9.53 Mn |
| Dec 31, 2025 | 10.36 Mn |
| Sep 30, 2025 | -16.29 Mn |
| Jun 30, 2025 | -15.84 Mn |
| Mar 31, 2025 | -13.27 Mn |
| Dec 31, 2024 | -13.09 Mn |
| Sep 30, 2024 | -14.02 Mn |
| Jun 30, 2024 | -13.93 Mn |
| Mar 31, 2024 | -17.20 Mn |
| Dec 31, 2023 | -17.66 Mn |
| Sep 30, 2023 | -16.75 Mn |
| Jun 30, 2023 | -19.36 Mn |
| Mar 31, 2023 | -22.65 Mn |
| Dec 31, 2022 | -22.47 Mn |
| Sep 30, 2022 | -19.79 Mn |
| Jun 30, 2022 | -24.61 Mn |
| Mar 31, 2022 | -21.35 Mn |
| Dec 31, 2021 | -19.70 Mn |
| Sep 30, 2021 | -16.25 Mn |
| Jun 30, 2021 | -23.18 Mn |