Xilio Therapeutics (XLO) EBITDA (2020 - 2026)

Xilio Therapeutics' (XLO) quarterly EBITDA came in at -$9.5 million in Q1 2026, up 28.16% year-on-year from -$7.4 million in Q1 2025, and down 191.98% quarter-over-quarter from $10.4 million in Q4 2025.

Xilio Therapeutics (XLO) EBITDA (2020 - 2026) Analysis & Trends

Xilio Therapeutics has disclosed EBITDA across 7 years of filings, most recently posting -$9.5 million for Q1 2026.

  • EBITDA for Q1 2026 came in at -$9.5 million, up 28.16% year-over-year; the trailing twelve-month figure through Mar 2026 was -$31.3 million (up 42.36% YoY), and the FY2025 annual result was -$35.0 million, up 39.84% from the prior year.
  • EBITDA came in at -$9.5 million for Q1 2026 at Xilio Therapeutics, down from $10.4 million in the prior quarter.
  • In the past five years, EBITDA ranged from a high of $10.4 million in Q4 2025 to a low of -$24.6 million in Q2 2022.
  • The 5-year median for EBITDA is -$16.7 million (2023), against an average of -$15.7 million.
  • Across the five-year window, EBITDA declined 28.12% in 2022 and surged 179.13% in 2025, its largest moves.
  • Xilio Therapeutics' EBITDA stood at -$22.5 million in 2022, then climbed by 21.41% to -$17.7 million in 2023, then grew by 25.84% to -$13.1 million in 2024, then soared by 179.13% to $10.4 million in 2025, then tumbled by 191.98% to -$9.5 million in 2026.
  • The last three EBITDA figures came in at -$9.5 million (Q1 2026), $10.4 million (Q4 2025), and -$16.3 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -26.92 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -13.63 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -19.70 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -14.44 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -752,618.00
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.14 Bn
9 Abivax 91.96 Bn 91.96 Bn - -65.83 Mn
10 Xilio Therapeutics 144.35 Mn -5.95 Mn - -9.53 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -9.53 Mn
Dec 31, 2025 10.36 Mn
Sep 30, 2025 -16.29 Mn
Jun 30, 2025 -15.84 Mn
Mar 31, 2025 -13.27 Mn
Dec 31, 2024 -13.09 Mn
Sep 30, 2024 -14.02 Mn
Jun 30, 2024 -13.93 Mn
Mar 31, 2024 -17.20 Mn
Dec 31, 2023 -17.66 Mn
Sep 30, 2023 -16.75 Mn
Jun 30, 2023 -19.36 Mn
Mar 31, 2023 -22.65 Mn
Dec 31, 2022 -22.47 Mn
Sep 30, 2022 -19.79 Mn
Jun 30, 2022 -24.61 Mn
Mar 31, 2022 -21.35 Mn
Dec 31, 2021 -19.70 Mn
Sep 30, 2021 -16.25 Mn
Jun 30, 2021 -23.18 Mn