Xilio Therapeutics (XLO) EBIT Margin (2024 - 2026)

Xilio Therapeutics' (XLO) quarterly EBIT Margin came in at 111.57% in Q1 2026, up 36116.0% year-on-year from N/an in Q1 2025, and down 29.01% quarter-over-quarter from 86.48% in Q4 2025.

Xilio Therapeutics (XLO) EBIT Margin (2024 - 2026) Analysis & Trends

Xilio Therapeutics has disclosed EBIT Margin across 3 years of filings, most recently posting 111.57% for Q1 2026.

  • EBIT Margin for Q1 2026 came in at 111.57%, up 36116.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 78.98% (up 53506.0% YoY), and the FY2025 annual result was 95.92%, up 85903.0% from the prior year.
  • EBIT Margin came in at 111.57% for Q1 2026 at Xilio Therapeutics, down from 86.48% in the prior quarter.
  • In the past five years, EBIT Margin ranged from a high of 10.12% in Q3 2025 to a low of 790.55% in Q4 2024.
  • The 3-year median for EBIT Margin is 325.22% (2025), against an average of 365.67%.
  • Across the five-year window, EBIT Margin jumped 70406 bps in 2025 and jumped 36116 bps in 2026, its largest moves.
  • Xilio Therapeutics' EBIT Margin stood at 790.55% in 2024, then jumped by 89 bps to 86.48% in 2025, then fell by 29 bps to 111.57% in 2026.
  • The last three EBIT Margin figures came in at 111.57% (Q1 2026), 86.48% (Q4 2025), and 10.12% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBIT Margin (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -6.43%
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 38.10%
9 Abivax 91.96 Bn 91.96 Bn - -
10 Xilio Therapeutics 144.35 Mn -5.95 Mn - -111.57%

Historic Data

Download Data
DateValue
Mar 31, 2026 -111.57%
Dec 31, 2025 -86.48%
Sep 30, 2025 -10.12%
Jun 30, 2025 -177.71%
Mar 31, 2025 -472.73%
Dec 31, 2024 -790.55%
Sep 30, 2024 -652.32%
Jun 30, 2024 -623.84%