Upstream Bio (UPB) Return on Equity [ROE] (2024 - 2026)
Upstream Bio (UPB) recorded Return on Equity [ROE] of -54.44% in Q2 2026, down 30.00 percentage points from -24.44% a year earlier and down 5.76 percentage points from the prior quarter.
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Analysis
Upstream Bio (UPB) Return on Equity [ROE] (2024 - 2026) Analysis & Trends
For FY2025, Upstream Bio reported Return on Equity [ROE] of -35.43%, up 2.43 percentage points from FY2024.
- Across earlier years, Return on Equity [ROE] came in at -37.86% in FY2024.
- Per Business Quant, the preceding three quarters came in at -48.69% (Q1 2026), -39.93% (Q4 2025) and -31.03% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,348.13 Bn | 1,321.74 Bn | 20.46 Bn | 74.39% |
| 2 | Johnson & Johnson | 675.90 Bn | 595.76 Bn | 17.30 Bn | 19.33% |
| 3 | AbbVie | 519.45 Bn | 487.50 Bn | 13.12 Bn | - |
| 4 | Merck | 364.95 Bn | 327.95 Bn | 13.19 Bn | 5.63% |
| 5 | Novartis Ag | 311.58 Bn | 285.16 Bn | - | - |
| 6 | Astrazeneca | 289.34 Bn | 262.94 Bn | 13.26 Bn | 21.60% |
| 7 | Amgen | 251.64 Bn | 203.30 Bn | 7.58 Bn | 72.13% |
| 8 | Gilead Sciences | 212.05 Bn | 187.07 Bn | 6.73 Bn | -31.17% |
| 9 | Pfizer | 167.35 Bn | 115.00 Bn | 12.56 Bn | 4.66% |
| 10 | Upstream Bio | 185.26 Mn | -919.50 Mn | - | -65.26% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Sep 30, 2026 | -65.26% |
| Jun 30, 2026 | -54.57% |
| Mar 31, 2026 | -48.79% |
| Dec 31, 2025 | -39.78% |
| Sep 30, 2025 | -31.01% |
| Jun 30, 2025 | -24.38% |
| Mar 31, 2025 | -17.21% |
| Dec 31, 2024 | -40.61% |
API Access
Upstream Bio Return on Equity [ROE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=UPB&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-equity-[roe]", "ticker": "UPB", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=UPB&period=max&api_key=YOUR_API_KEY");
const data = await res.json();