Upstream Bio (UPB) Return on Equity [ROE] (2024 - 2026)
Upstream Bio (UPB) recorded Return on Equity [ROE] of -54.44% in Q2 2026, down 30.00 percentage points from -24.44% a year earlier and down 5.76 percentage points from the prior quarter.
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Analysis
Upstream Bio (UPB) Return on Equity [ROE] (2024 - 2026) Analysis & Trends
For FY2025, Upstream Bio reported Return on Equity [ROE] of -35.43%, up 2.43 percentage points from FY2024.
- Across earlier years, Return on Equity [ROE] came in at -37.86% in FY2024.
- Per Business Quant, the preceding three quarters came in at -48.69% (Q1 2026), -39.93% (Q4 2025) and -31.03% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROE (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 25.32% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | - |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | 7.21% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 84.40% |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 21.39% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 83.75% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -18.38% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 4.97% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 22.24% |
| 10 | Upstream Bio | 288.64 Mn | 288.64 Mn | -3.29 Mn | -54.44% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -54.44% |
| Mar 31, 2026 | -48.69% |
| Dec 31, 2025 | -39.93% |
| Sep 30, 2025 | -31.03% |
| Jun 30, 2025 | -24.44% |
| Mar 31, 2025 | -17.29% |
| Dec 31, 2024 | -42.41% |
API Access
Upstream Bio Return on Equity [ROE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=UPB&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-equity-[roe]", "ticker": "UPB", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=UPB&period=max&api_key=YOUR_API_KEY");
const data = await res.json();