Upstream Bio (UPB) Return on Assets [ROA] (2024 - 2026)
Upstream Bio (UPB) posted Return on Assets [ROA] of -52.24% for Q2 2026, down 28.42 percentage points from -23.82% a year earlier and down 5.58 percentage points from the prior quarter.
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Analysis
Upstream Bio (UPB) Return on Assets [ROA] (2024 - 2026) Analysis & Trends
For FY2025, Upstream Bio's Return on Assets [ROA] came in at -34.33%, down 12.41 percentage points from FY2024.
- In prior years, Upstream Bio's Return on Assets [ROA] was -21.92% in FY2024.
- On a year-over-year basis, Return on Assets [ROA] has declined in each of the last three quarters.
- According to Business Quant data, Return on Assets [ROA] for the three prior quarters was -46.65% (Q1 2026), -38.51% (Q4 2025) and -30.10% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROA (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 10.47% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | 4.65% |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | 2.45% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 28.37% |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 9.10% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 9.29% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -6.13% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 2.14% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 16.34% |
| 10 | Upstream Bio | 288.64 Mn | 288.64 Mn | -3.29 Mn | -52.24% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -52.24% |
| Mar 31, 2026 | -46.65% |
| Dec 31, 2025 | -38.51% |
| Sep 30, 2025 | -30.10% |
| Jun 30, 2025 | -23.82% |
| Mar 31, 2025 | -16.88% |
| Dec 31, 2024 | -18.38% |
API Access
Upstream Bio Return on Assets [ROA] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-assets-%5Broa%5D&ticker=UPB&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-assets-[roa]", "ticker": "UPB", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-assets-%5Broa%5D&ticker=UPB&period=max&api_key=YOUR_API_KEY");
const data = await res.json();