Upstream Bio (UPB) Retained Earnings (2023 - 2026)

Upstream Bio's (UPB) quarterly Retained Earnings came in at -$374.8 million in Q1 2026, down 156.51% year-on-year from $663.2 million in Q1 2025, and down 70819.62% quarter-over-quarter from $530000.0 in Q4 2025.

Upstream Bio (UPB) Retained Earnings (2023 - 2026) Analysis & Trends

Upstream Bio's Retained Earnings history runs 4 years deep, the most recent figure standing at -$374.8 million for Q1 2026.

  • On a quarterly basis, Retained Earnings fell 156.51% year-over-year to -$374.8 million in Q1 2026; TTM through Mar 2026 was -$374.8 million, a 156.51% decrease from a year earlier, with the FY2025 full-year figure at $530000.0, down 99.92% from the prior year.
  • Retained Earnings retreated to -$374.8 million in Q1 2026 per UPB's latest filing, from $530000.0 in the prior quarter.
  • Across five years, Retained Earnings topped out at $666.4 million in Q2 2025 and bottomed at -$374.8 million in Q1 2026.
  • The 4-year median for Retained Earnings is $6.8 million (2023), against an average of $203.8 million.
  • Across the five-year window, Retained Earnings surged 13594.11% in 2024 and sank 156.51% in 2026, its largest moves.
  • Year by year, Retained Earnings stood at $4.8 million in 2023, then jumped by 13594.11% to $660.6 million in 2024, then sank by 99.92% to $530000.0 in 2025, then slumped by 70819.62% to -$374.8 million in 2026.
  • Per Business Quant, the three latest UPB Retained Earnings figures stand at -$374.8 million (Q1 2026), $530000.0 (Q4 2025), and $493000.0 (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Retained Earnings (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -527.87 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -27.89 Mn
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 12.91 Bn
4 NuCana 279.75 Bn 279.75 Bn - 115.82 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 14.59 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 11.90 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn 1.41 Bn
9 Revolution Medicines 37.78 Bn 37.78 Bn - -622,000.00
10 Upstream Bio 347.73 Mn 347.73 Mn -3.94 Mn -374.81 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -374.81 Mn
Dec 31, 2025 530,000.00
Sep 30, 2025 493,000.00
Jun 30, 2025 666.45 Mn
Mar 31, 2025 663.24 Mn
Dec 31, 2024 660.60 Mn
Sep 30, 2024 8.87 Mn
Dec 31, 2023 4.82 Mn