Upstream Bio UPB
NASDAQ UPB
$6.01 -0.07 (-1.15%)
As of: Sep 4, 2026 · 3:59 PM EDT

Upstream Bio (UPB) Retained Earnings (2023 - 2026)

Upstream Bio (UPB) posted quarterly Retained Earnings of -$374.8 million for Q1 2026, down 156.51% year-over-year from $663.2 million in Q1 2025, and down 70819.62% quarter-over-quarter from $530000.0 in Q4 2025.

Analysis

Upstream Bio (UPB) Retained Earnings (2023 - 2026) Analysis & Trends

Upstream Bio's Retained Earnings history runs 4 years deep, the most recent figure standing at -$374.8 million for Q1 2026.

  • In Q1 2026, Retained Earnings fell 156.51% year-over-year to -$374.8 million; the TTM figure through Mar 2026 stood at -$374.8 million (down 156.51% YoY), while the FY2025 annual figure was $530000.0, down 99.92% from the prior year.
  • Retained Earnings for Q1 2026 stood at -$374.8 million, down from $530000.0 in the prior quarter.
  • The five-year high for Retained Earnings was $666.4 million in Q2 2025, with the low at -$374.8 million in Q1 2026.
  • The 4-year median for Retained Earnings is $6.8 million (2023), against an average of $203.8 million.
  • The sharpest annual moves came in 2024 and 2026: Retained Earnings surged 13594.11% in 2024, then plunged 156.51% in 2026.
  • Upstream Bio's Retained Earnings stood at $4.8 million in 2023, then soared by 13594.11% to $660.6 million in 2024, then slumped by 99.92% to $530000.0 in 2025, then tumbled by 70819.62% to -$374.8 million in 2026.
  • Business Quant data shows UPB's Retained Earnings at -$374.8 million in Q1 2026, $530000.0 in Q4 2025, and $493000.0 in Q3 2025.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Retained Earnings (Qtr)
1 Vertex Pharmaceuticals 138.47 Bn 130.62 Bn 2.84 Bn 15.69 Bn
2 Regeneron Pharmaceuticals 85.18 Bn 77.19 Bn 3.93 Bn 37.62 Bn
3 Argenx Se 63.38 Bn 58.19 Bn 1.37 Bn 558.00 Mn
4 Moderna 58.09 Bn 52.95 Bn 52.00 Mn 5.10 Bn
5 Revolution Medicines 44.33 Bn 44.33 Bn - -4.00 Bn
6 BeOne Medicines 40.02 Bn 34.92 Bn 1.53 Bn 13.05 Bn
7 Alnylam Pharmaceuticals 35.57 Bn 32.27 Bn 992.69 Mn -6.33 Bn
8 Royalty Pharma 28.45 Bn 27.61 Bn - 4.38 Bn
9 Insmed 27.48 Bn 26.32 Bn 358.27 Mn 6.57 Bn
10 Upstream Bio 327.95 Mn 327.95 Mn -3.29 Mn 685.54 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 685.54 Mn
Mar 31, 2026 678.66 Mn
Dec 31, 2025 673.41 Mn
Sep 30, 2025 669.80 Mn
Jun 30, 2025 666.45 Mn
Mar 31, 2025 663.24 Mn
Dec 31, 2024 660.60 Mn
Sep 30, 2024 -169.54 Mn
Dec 31, 2023 -127.97 Mn