Upstream Bio (UPB) Research & Development (2023 - 2026)
Upstream Bio (UPB) reported Research & Development of $36.09 million for Q2 2026, down 4.7% from $37.87 million a year earlier and down 1.3% from the prior quarter.
Powered by 
Analysis
Upstream Bio (UPB) Research & Development (2023 - 2026) Analysis & Trends
Over the twelve months ended Jun 30, 2026, Upstream Bio's Research & Development came in at $145.8 million, up 44.5% year-over-year; for FY2025, it was $136.81 million, up 117.3% from FY2024.
- By year, Research & Development came in at $62.97 million in FY2024 (+98.0%) and $31.8 million in FY2023.
- Five-year quarterly Research & Development spans a low of $7.79 million in Q3 2023 and a high of $40.17 million in Q4 2025.
- Year over year, Research & Development gained in seven of the last eight quarters, with growth averaging 89.0%.
- The high point for year-over-year Research & Development in five years was Q2 2025 (growth of 169.1%); the low point was Q2 2026 (a decline of 4.7%).
- Per Business Quant data, the three quarters before Q2 2026 came in at $36.57 million (Q1 2026), $40.17 million (Q4 2025) and $32.98 million (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | R&D (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 3.65 Bn |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 2.34 Bn |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | 9.74 Bn |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | -2.85 Bn |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | -4.05 Bn |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 1.87 Bn |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | 1.76 Bn |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 2.81 Bn |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 993.80 Mn |
| 10 | Upstream Bio | 290.29 Mn | 290.29 Mn | -3.29 Mn | 36.09 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 36.09 Mn |
| Mar 31, 2026 | 36.57 Mn |
| Dec 31, 2025 | 40.17 Mn |
| Sep 30, 2025 | 32.98 Mn |
| Jun 30, 2025 | 37.87 Mn |
| Mar 31, 2025 | 25.80 Mn |
| Dec 31, 2024 | 21.77 Mn |
| Sep 30, 2024 | 15.43 Mn |
| Jun 30, 2024 | 14.07 Mn |
| Mar 31, 2024 | 11.69 Mn |
| Dec 31, 2023 | 11.55 Mn |
| Sep 30, 2023 | 7.79 Mn |
API Access
Upstream Bio Research & Development API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=research-and-development&ticker=UPB&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "research-and-development", "ticker": "UPB", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=research-and-development&ticker=UPB&period=max&api_key=YOUR_API_KEY");
const data = await res.json();