Upstream Bio (UPB) Profit After Tax (2023 - 2026)

Upstream Bio's Profit After Tax history runs 4 years deep, the most recent figure standing at -$40.6 million for Q1 2026.

• In Q1 2026, Profit After Tax fell 48.88% year-over-year to -$40.6 million; the TTM figure through Mar 2026 stood at -$156.7 million (down 97.92% YoY), while the FY2025 annual figure was -$143.4 million, down 128.32% from the prior year.
• Profit After Tax was -$40.6 million for Q1 2026 at Upstream Bio, up from -$42.4 million in the prior quarter.
• In the past five years, Profit After Tax ranged from a high of -$3.1 million in Q3 2023 to a low of -$42.4 million in Q4 2025.
• Historically, Profit After Tax has averaged -$23.8 million across 4 years, with a median of -$21.2 million in 2024.
• The sharpest annual moves came in 2024 and 2026: Profit After Tax sank 415.54% in 2024, then plunged 48.88% in 2026.
• A 4-year view of Profit After Tax shows it stood at -$11.8 million in 2023, then tumbled by 80.08% to -$21.2 million in 2024, then slumped by 99.6% to -$42.4 million in 2025, then increased by 4.25% to -$40.6 million in 2026.
• The last three Profit After Tax figures came in at -$40.6 million (Q1 2026), -$42.4 million (Q4 2025), and -$33.7 million (Q3 2025), per Business Quant data.