Upstream Bio (UPB) Operating Income (2023 - 2026)
Upstream Bio (UPB) recorded Operating Income of -$42.37 million in Q2 2026, compared with -$44.35 million a year earlier.
Powered by 
Analysis
Upstream Bio (UPB) Operating Income (2023 - 2026) Analysis & Trends
On a TTM basis, Upstream Bio's Operating Income came in at -$169.98 million as of Jun 30, 2026; for FY2025, it came in at -$160.36 million.
- Across earlier years, Operating Income came in at -$77.76 million in FY2024 and -$40.11 million in FY2023.
- Quarterly Operating Income has ranged from -$46.17 million in Q4 2025 to -$9.39 million in Q3 2023 over the past five years.
- Per Business Quant, the preceding three quarters came in at -$43.62 million (Q1 2026), -$46.17 million (Q4 2025) and -$37.83 million (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Op. Inc (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,146.94 Bn | 1,115.53 Bn | 19.71 Bn | 11.75 Bn |
| 2 | Johnson & Johnson | 624.96 Bn | 543.49 Bn | 17.26 Bn | 7.14 Bn |
| 3 | AbbVie | 510.15 Bn | 483.27 Bn | 12.70 Bn | 6.43 Bn |
| 4 | Merck | 366.13 Bn | 320.51 Bn | 12.21 Bn | -584.00 Mn |
| 5 | Novartis Ag | 297.75 Bn | 261.74 Bn | 11.24 Bn | 4.75 Bn |
| 6 | Astrazeneca | 261.93 Bn | 235.62 Bn | 12.86 Bn | 3.16 Bn |
| 7 | Amgen | 236.51 Bn | 191.91 Bn | 7.24 Bn | 3.51 Bn |
| 8 | Gilead Sciences | 194.27 Bn | 168.47 Bn | 6.22 Bn | -10.39 Bn |
| 9 | Pfizer | 171.74 Bn | 118.39 Bn | 10.94 Bn | 4.27 Bn |
| 10 | Upstream Bio | 152.79 Mn | -1.12 Bn | -3.29 Mn | -42.37 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -42.37 Mn |
| Mar 31, 2026 | -43.62 Mn |
| Dec 31, 2025 | -46.17 Mn |
| Sep 30, 2025 | -37.83 Mn |
| Jun 30, 2025 | -44.35 Mn |
| Mar 31, 2025 | -32.01 Mn |
| Dec 31, 2024 | -26.32 Mn |
| Sep 30, 2024 | -18.89 Mn |
| Jun 30, 2024 | -17.54 Mn |
| Mar 31, 2024 | -15.01 Mn |
| Dec 31, 2023 | -14.33 Mn |
| Sep 30, 2023 | -9.39 Mn |
API Access
Upstream Bio Operating Income API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-income&ticker=UPB&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-income", "ticker": "UPB", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-income&ticker=UPB&period=max&api_key=YOUR_API_KEY");
const data = await res.json();