Upstream Bio (UPB) Non Operating Income (2023 - 2026)

Upstream Bio's (UPB) quarterly Non Operating Income came in at $3.0 million in Q1 2026, up 122.87% quarter-over-quarter from -$13.2 million in Q4 2025.

Upstream Bio (UPB) Non Operating Income (2023 - 2026) Analysis & Trends

Upstream Bio's Non Operating Income history runs 4 years deep, the most recent figure standing at $3.0 million for Q1 2026.

  • On a quarterly basis, Non Operating Income changed N/A year-over-year to $3.0 million in Q1 2026; TTM through Mar 2026 was -$1.7 million, a 116.0% decrease from a year earlier, with the FY2025 full-year figure at -$15000.0, down 100.1% from the prior year.
  • Non Operating Income grew to $3.0 million in Q1 2026 per UPB's latest filing, from -$13.2 million in the prior quarter.
  • Across five years, Non Operating Income topped out at $19.7 million in Q4 2023 and bottomed at -$13.2 million in Q4 2025.
  • The 4-year median for Non Operating Income is $4.1 million (2024), against an average of $3.9 million.
  • Biggest YoY gain for Non Operating Income was 53.07% in 2025; the steepest drop was 360.54% in 2025.
  • Year by year, Non Operating Income stood at $19.7 million in 2023, then slumped by 74.21% to $5.1 million in 2024, then plunged by 360.54% to -$13.2 million in 2025, then jumped by 122.87% to $3.0 million in 2026.
  • Per Business Quant, the three latest UPB Non Operating Income figures stand at $3.0 million (Q1 2026), -$13.2 million (Q4 2025), and $4.1 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Non Op. Inc. (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -9.22 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - 444,000.00
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn -
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn -
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 188.30 Mn
7 Belite Bio 61.40 Bn 61.40 Bn - 5.75 Mn
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn -
9 Revolution Medicines 37.37 Bn 37.37 Bn - -8.59 Mn
10 Upstream Bio 343.65 Mn 343.65 Mn -3.94 Mn 3.02 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 3.02 Mn
Dec 31, 2025 -13.23 Mn
Sep 30, 2025 4.09 Mn
Jun 30, 2025 4.38 Mn
Dec 31, 2024 5.08 Mn
Sep 30, 2024 2.90 Mn
Jun 30, 2024 2.86 Mn
Mar 31, 2024 4.12 Mn
Dec 31, 2023 19.69 Mn
Sep 30, 2023 6.28 Mn