Upstream Bio (UPB) Net Margin (2023 - 2026)
Upstream Bio (UPB) reported Net Margin of -5136.09% for Q2 2026, down 870.78 percentage points from -4265.31% a year earlier and down 1210.46 percentage points from the prior quarter.
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Analysis
Upstream Bio (UPB) Net Margin (2023 - 2026) Analysis & Trends
Over the twelve months ended Jun 30, 2026, Upstream Bio's Net Margin came in at -4955.67%, down 913.84 percentage points year-over-year; for FY2025, it came in at -5026.03%, down 1802.62 percentage points from FY2024.
- By year, Net Margin came in at -3223.42% in FY2024 (-1616.06 pp) and -1607.35% in FY2023.
- Five-year quarterly Net Margin spans a low of -6356.14% in Q4 2025 and a high of -1006.92% in Q3 2023.
- Year over year, Net Margin gained in 1 of the last eight quarters, with an average year-over-year change of -1249.69 percentage points.
- The high point for year-over-year Net Margin in five years was Q1 2026 (a gain of 892.39 percentage points); the low point was Q4 2025 (a drop of 2801.49 percentage points).
- Per Business Quant data, the three quarters before Q2 2026 came in at -3925.63% (Q1 2026), -6356.14% (Q4 2025) and -4941.14% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 21.86% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 21.27% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -8.04% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 22.61% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 18.81% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 23.62% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -134.51% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | -1.65% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 32.99% |
| 10 | Upstream Bio | 290.29 Mn | 290.29 Mn | -3.29 Mn | -5,136.09% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -5,136.09% |
| Mar 31, 2026 | -3,925.63% |
| Dec 31, 2025 | -6,356.14% |
| Sep 30, 2025 | -4,941.14% |
| Jun 30, 2025 | -4,265.31% |
| Mar 31, 2025 | -4,818.02% |
| Dec 31, 2024 | -3,554.65% |
| Sep 30, 2024 | -3,465.07% |
| Jun 30, 2024 | -3,835.69% |
| Mar 31, 2024 | -2,189.06% |
| Dec 31, 2023 | -3,329.78% |
| Sep 30, 2023 | -1,006.92% |
API Access
Upstream Bio Net Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=net-margin&ticker=UPB&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "net-margin", "ticker": "UPB", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=net-margin&ticker=UPB&period=max&api_key=YOUR_API_KEY");
const data = await res.json();