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Upstream Bio (UPB) Net Cash Flow: 2023-2025

Historic Net Cash Flow for Upstream Bio (UPB) over the last 2 years, with Sep 2025 value amounting to $26.7 million.

  • Upstream Bio's Net Cash Flow rose 288.15% to $26.7 million in Q3 2025 from the same period last year, while for Sep 2025 it was $39.2 million, marking a year-over-year increase of 376.64%. This contributed to the annual value of $300.3 million for FY2024, which is 3318.96% up from last year.
  • As of Q3 2025, Upstream Bio's Net Cash Flow stood at $26.7 million, which was up 203.30% from -$25.9 million recorded in Q2 2025.
  • Over the past 5 years, Upstream Bio's Net Cash Flow peaked at $292.9 million during Q4 2024, and registered a low of -$254.6 million during Q1 2025.
  • Over the past 3 years, Upstream Bio's median Net Cash Flow value was -$4.3 million (recorded in 2024), while the average stood at $3.1 million.
  • Per our database at Business Quant, Upstream Bio's Net Cash Flow skyrocketed by 1,463.48% in 2024 and then plummeted by 4,584.41% in 2025.
  • Over the past 3 years, Upstream Bio's Net Cash Flow (Quarterly) stood at -$21.5 million in 2023, then soared by 1,463.48% to $292.9 million in 2024, then surged by 288.15% to $26.7 million in 2025.
  • Its last three reported values are $26.7 million in Q3 2025, -$25.9 million for Q2 2025, and -$254.6 million during Q1 2025.