Upstream Bio (UPB) FCF Margin (2023 - 2026)
Upstream Bio's FCF Margin came in at -4608.15% for Q2 2026, down 420.42 percentage points from -4187.73% a year earlier but up 19.70 percentage points from the prior quarter.
Powered by 
Analysis
Upstream Bio (UPB) FCF Margin (2023 - 2026) Analysis & Trends
Over the trailing twelve months to Jun 30, 2026, Upstream Bio reported FCF Margin of -4321.15%, down 128.61 percentage points year-over-year; for FY2025, it came in at -4675.54%, down 2157.27 percentage points from FY2024.
- Going back by year, FCF Margin was -2518.27% in FY2024 (-918.69 pp) and -1599.58% in FY2023.
- The five-year range for quarterly FCF Margin is -7272.97% (Q1 2025) to -1575.69% (Q2 2024).
- Year-over-year, FCF Margin increased in two of the last seven quarters, with an average year-over-year change of -985.04 percentage points.
- Business Quant data shows UPB's FCF Margin at -4627.85% (Q1 2026), -4593.56% (Q4 2025) and -3265.59% (Q3 2025) in the three quarters before Q2 2026.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | FCF Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.82% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 18.33% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | 26.96% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 43.05% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 34.72% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.70% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | 44.00% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 2.01% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 30.39% |
| 10 | Upstream Bio | 290.29 Mn | 290.29 Mn | -3.29 Mn | -4,608.15% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -4,608.15% |
| Mar 31, 2026 | -4,627.85% |
| Dec 31, 2025 | -4,593.56% |
| Sep 30, 2025 | -3,265.59% |
| Jun 30, 2025 | -4,187.73% |
| Mar 31, 2025 | -7,272.97% |
| Dec 31, 2024 | -3,229.53% |
| Sep 30, 2024 | -2,300.16% |
| Jun 30, 2024 | -1,575.69% |
| Mar 31, 2024 | -2,744.06% |
| Dec 31, 2023 | -3,580.00% |
API Access
Upstream Bio FCF Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=fcf-margin&ticker=UPB&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "fcf-margin", "ticker": "UPB", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=fcf-margin&ticker=UPB&period=max&api_key=YOUR_API_KEY");
const data = await res.json();