Upstream Bio (UPB) Cost of Revenue (2024 - 2026)

Upstream Bio's quarterly Cost of Revenue came in at $5.0 million in Q1 2026, up 133.58% year-on-year from $2.1 million in Q1 2025, and down 40.39% quarter-over-quarter from $8.3 million in Q4 2025.

Upstream Bio has reported Cost of Revenue for 3 years, with the latest figure at $5.0 million in Q1 2026.

  • For the quarter ending Q1 2026, Cost of Revenue rose 133.58% year-over-year to $5.0 million; the trailing twelve-month figure through Mar 2026 stood at $25.9 million (up 204.77% YoY), and the FY2025 full-year result was $23.0 million, up 249.74% from the prior year.
  • Cost of Revenue for Q1 2026 stood at $5.0 million, down from $8.3 million in the prior quarter.
  • The five-year high for Cost of Revenue was $10.0 million in Q2 2025, with the low at $351000.0 in Q1 2024.
  • Average Cost of Revenue over 3 years is $3.9 million, with a median of $2.5 million recorded in 2025.
  • Peak annual rise in Cost of Revenue reached 606.21% in 2025, while the deepest fall reached 16.66% in 2025.
  • Tracing UPB's Cost of Revenue over 3 years: stood at $2.8 million in 2024, then soared by 202.25% to $8.3 million in 2025, then tumbled by 40.39% to $5.0 million in 2026.
  • The last three Cost of Revenue figures came in at $5.0 million (Q1 2026), $8.3 million (Q4 2025), and $2.5 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Cost of Rev (Qtr)
1 Quantum Biopharma 1,216,509.61 Bn 1,216,509.61 Bn - -
2 Alterity Therapeutics 764,224.41 Bn 764,224.38 Bn - -
3 Legend Biotech 2,716.00 Bn 2,715.71 Bn 242.10 Mn 64.20 Mn
4 Nanobiotix 2,248.83 Bn 2,248.77 Bn - -
5 Akari Therapeutics 1,951.18 Bn 1,951.17 Bn - -
6 Vertex Pharmaceuticals 113.69 Bn 106.44 Bn 2.59 Bn 392.80 Mn
7 Evaxion A 64.16 Bn 64.14 Bn - -
8 Regeneron Pharmaceuticals 63.94 Bn 55.18 Bn 3.31 Bn 296.00 Mn
9 Alnylam Pharmaceuticals 40.13 Bn 37.12 Bn 959.66 Mn 207.52 Mn
10 Upstream Bio 454.22 Mn 454.22 Mn -3.94 Mn 4.97 Mn

Historic Data

Download Data 🔒
DateValue
Mar 31, 2026 4.97 Mn
Mar 31, 2026 4.97 Mn
Dec 31, 2025 8.34 Mn
Dec 31, 2025 8.34 Mn
Sep 30, 2025 2.54 Mn
Sep 30, 2025 2.54 Mn
Jun 30, 2025 10.00 Mn
Jun 30, 2025 10.00 Mn
Mar 31, 2025 2.13 Mn
Mar 31, 2025 2.13 Mn
Dec 31, 2024 2.76 Mn
Dec 31, 2024 2.76 Mn
Sep 30, 2024 2.18 Mn
Sep 30, 2024 2.18 Mn
Jun 30, 2024 1.42 Mn
Jun 30, 2024 1.42 Mn
Mar 31, 2024 351,000.00
Mar 31, 2024 351,000.00