Upstream Bio (UPB) Cost of Revenue (2024 - 2026)
Upstream Bio's quarterly Cost of Revenue came in at $5.0 million in Q1 2026, up 133.58% year-on-year from $2.1 million in Q1 2025, and down 40.39% quarter-over-quarter from $8.3 million in Q4 2025.
Upstream Bio has reported Cost of Revenue for 3 years, with the latest figure at $5.0 million in Q1 2026.
- For the quarter ending Q1 2026, Cost of Revenue rose 133.58% year-over-year to $5.0 million; the trailing twelve-month figure through Mar 2026 stood at $25.9 million (up 204.77% YoY), and the FY2025 full-year result was $23.0 million, up 249.74% from the prior year.
- Cost of Revenue for Q1 2026 stood at $5.0 million, down from $8.3 million in the prior quarter.
- The five-year high for Cost of Revenue was $10.0 million in Q2 2025, with the low at $351000.0 in Q1 2024.
- Average Cost of Revenue over 3 years is $3.9 million, with a median of $2.5 million recorded in 2025.
- Peak annual rise in Cost of Revenue reached 606.21% in 2025, while the deepest fall reached 16.66% in 2025.
- Tracing UPB's Cost of Revenue over 3 years: stood at $2.8 million in 2024, then soared by 202.25% to $8.3 million in 2025, then tumbled by 40.39% to $5.0 million in 2026.
- The last three Cost of Revenue figures came in at $5.0 million (Q1 2026), $8.3 million (Q4 2025), and $2.5 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Cost of Rev (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,216,509.61 Bn | 1,216,509.61 Bn | - | - |
| 2 | Alterity Therapeutics | 764,224.41 Bn | 764,224.38 Bn | - | - |
| 3 | Legend Biotech | 2,716.00 Bn | 2,715.71 Bn | 242.10 Mn | 64.20 Mn |
| 4 | Nanobiotix | 2,248.83 Bn | 2,248.77 Bn | - | - |
| 5 | Akari Therapeutics | 1,951.18 Bn | 1,951.17 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 113.69 Bn | 106.44 Bn | 2.59 Bn | 392.80 Mn |
| 7 | Evaxion A | 64.16 Bn | 64.14 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 63.94 Bn | 55.18 Bn | 3.31 Bn | 296.00 Mn |
| 9 | Alnylam Pharmaceuticals | 40.13 Bn | 37.12 Bn | 959.66 Mn | 207.52 Mn |
| 10 | Upstream Bio | 454.22 Mn | 454.22 Mn | -3.94 Mn | 4.97 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 4.97 Mn |
| Mar 31, 2026 | 4.97 Mn |
| Dec 31, 2025 | 8.34 Mn |
| Dec 31, 2025 | 8.34 Mn |
| Sep 30, 2025 | 2.54 Mn |
| Sep 30, 2025 | 2.54 Mn |
| Jun 30, 2025 | 10.00 Mn |
| Jun 30, 2025 | 10.00 Mn |
| Mar 31, 2025 | 2.13 Mn |
| Mar 31, 2025 | 2.13 Mn |
| Dec 31, 2024 | 2.76 Mn |
| Dec 31, 2024 | 2.76 Mn |
| Sep 30, 2024 | 2.18 Mn |
| Sep 30, 2024 | 2.18 Mn |
| Jun 30, 2024 | 1.42 Mn |
| Jun 30, 2024 | 1.42 Mn |
| Mar 31, 2024 | 351,000.00 |
| Mar 31, 2024 | 351,000.00 |