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Upstream Bio (UPB) Change in Cash (2023 - 2025)

Upstream Bio has reported Change in Cash over the past 3 years, most recently at $29.4 million for Q4 2025.

  • Quarterly results put Change in Cash at $29.4 million for Q4 2025, down 89.96% from a year ago — trailing twelve months through Dec 2025 was -$224.3 million (down 174.71% YoY), and the annual figure for FY2025 was -$224.3 million, down 174.71%.
  • Change in Cash for Q4 2025 was $29.4 million at Upstream Bio, up from $26.7 million in the prior quarter.
  • Over the last five years, Change in Cash for UPB hit a ceiling of $292.9 million in Q4 2024 and a floor of -$254.6 million in Q1 2025.
  • Median Change in Cash over the past 3 years was $5.7 million (2024), compared with a mean of $6.1 million.
  • Biggest five-year swings in Change in Cash: surged 1463.48% in 2024 and later crashed 4584.41% in 2025.
  • Upstream Bio's Change in Cash stood at -$21.5 million in 2023, then surged by 1463.48% to $292.9 million in 2024, then tumbled by 89.96% to $29.4 million in 2025.
  • The last three reported values for Change in Cash were $29.4 million (Q4 2025), $26.7 million (Q3 2025), and -$25.9 million (Q2 2025) per Business Quant data.