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Upstream Bio (UPB) Change in Cash: 2023-2025

Historic Change in Cash for Upstream Bio (UPB) over the last 2 years, with Sep 2025 value amounting to $26.7 million.

  • Upstream Bio's Change in Cash rose 288.15% to $26.7 million in Q3 2025 from the same period last year, while for Sep 2025 it was $39.2 million, marking a year-over-year increase of 376.64%. This contributed to the annual value of $300.3 million for FY2024, which is 3318.96% up from last year.
  • According to the latest figures from Q3 2025, Upstream Bio's Change in Cash is $26.7 million, which was up 203.30% from -$25.9 million recorded in Q2 2025.
  • Upstream Bio's Change in Cash's 5-year high stood at $292.9 million during Q4 2024, with a 5-year trough of -$254.6 million in Q1 2025.
  • Moreover, its 3-year median value for Change in Cash was -$4.3 million (2024), whereas its average is $3.1 million.
  • Per our database at Business Quant, Upstream Bio's Change in Cash skyrocketed by 1,463.48% in 2024 and then tumbled by 4,584.41% in 2025.
  • Quarterly analysis of 3 years shows Upstream Bio's Change in Cash stood at -$21.5 million in 2023, then soared by 1,463.48% to $292.9 million in 2024, then spiked by 288.15% to $26.7 million in 2025.
  • Its Change in Cash stands at $26.7 million for Q3 2025, versus -$25.9 million for Q2 2025 and -$254.6 million for Q1 2025.