Upstream Bio (UPB) Change in Acquisitions & Divestments (2023 - 2026)

Upstream Bio's (UPB) quarterly Change in Acquisitions & Divestments came in at $56.8 million in Q1 2026, up 7.87% year-on-year from $52.7 million in Q1 2025, and down 41.59% quarter-over-quarter from $97.3 million in Q4 2025.

Upstream Bio (UPB) Change in Acquisitions & Divestments (2023 - 2026) Analysis & Trends

Upstream Bio's Change in Acquisitions & Divestments history runs 4 years deep, the most recent figure standing at $56.8 million for Q1 2026.

  • On a quarterly basis, Change in Acquisitions & Divestments rose 7.87% year-over-year to $56.8 million in Q1 2026; TTM through Mar 2026 was $296.7 million, a 20.1% increase from a year earlier, with the FY2025 full-year figure at $292.6 million, up 26.3% from the prior year.
  • Change in Acquisitions & Divestments slipped to $56.8 million in Q1 2026 per UPB's latest filing, from $97.3 million in the prior quarter.
  • Across five years, Change in Acquisitions & Divestments topped out at $97.3 million in Q4 2025 and bottomed at $29.6 million in Q4 2023.
  • The 4-year median for Change in Acquisitions & Divestments is $63.4 million (2025), against an average of $61.1 million.
  • Across the five-year window, Change in Acquisitions & Divestments surged 185.25% in 2024 and decreased 3.23% in 2025, its largest moves.
  • Year by year, Change in Acquisitions & Divestments stood at $29.6 million in 2023, then jumped by 185.25% to $84.3 million in 2024, then advanced by 15.39% to $97.3 million in 2025, then tumbled by 41.59% to $56.8 million in 2026.
  • Per Business Quant, the three latest UPB Change in Acquisitions & Divestments figures stand at $56.8 million (Q1 2026), $97.3 million (Q4 2025), and $72.7 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Oculis Holding AG 67,222.41 Bn 67,222.13 Bn -
2 Nanobiotix 1,909.44 Bn 1,909.38 Bn -
3 Akari Therapeutics 989.71 Bn 989.71 Bn -
4 BeOne Medicines 471.12 Bn 466.33 Bn 1.35 Bn
5 Vertex Pharmaceuticals 121.84 Bn 114.59 Bn 2.59 Bn
6 Regeneron Pharmaceuticals 69.89 Bn 61.14 Bn 3.31 Bn
7 Belite Bio 62.74 Bn 62.74 Bn -
8 Argenx Se 55.83 Bn 50.64 Bn 1.41 Bn
9 Alnylam Pharmaceuticals 37.34 Bn 34.34 Bn 959.66 Mn
10 Upstream Bio 346.37 Mn 346.37 Mn -3.94 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 56.82 Mn
Mar 31, 2026 56.82 Mn
Dec 31, 2025 97.28 Mn
Dec 31, 2025 97.28 Mn
Sep 30, 2025 72.71 Mn
Sep 30, 2025 72.71 Mn
Jun 30, 2025 69.90 Mn
Jun 30, 2025 69.90 Mn
Mar 31, 2025 52.68 Mn
Mar 31, 2025 52.68 Mn
Dec 31, 2024 84.30 Mn
Dec 31, 2024 84.30 Mn
Sep 30, 2024 75.14 Mn
Sep 30, 2024 75.14 Mn
Jun 30, 2024 34.93 Mn
Jun 30, 2024 34.93 Mn
Mar 31, 2024 37.26 Mn
Mar 31, 2024 37.26 Mn
Dec 31, 2023 29.55 Mn
Dec 31, 2023 29.55 Mn