Upstream Bio (UPB) Change in Accured Expenses (2023 - 2026)

Upstream Bio's quarterly Change in Accured Expenses came in at $1.2 million in Q1 2026, up 166.4% year-on-year from $461342.3 in Q1 2025, and down 56.43% quarter-over-quarter from $2.8 million in Q4 2025.

Upstream Bio has reported Change in Accured Expenses for 4 years, with the latest figure at $1.2 million in Q1 2026.

  • For the quarter ending Q1 2026, Change in Accured Expenses rose 166.4% year-over-year to $1.2 million; the trailing twelve-month figure through Mar 2026 stood at $7.1 million (up 1201.65% YoY), and the FY2025 full-year result was $4.0 million, up 165.48% from the prior year.
  • Change in Accured Expenses for Q1 2026 stood at $1.2 million, down from $2.8 million in the prior quarter.
  • The five-year high for Change in Accured Expenses was $3.5 million in Q2 2025, with the low at -$1.9 million in Q1 2025.
  • Average Change in Accured Expenses over 4 years is $739400.0, with a median of $510500.0 recorded in 2023.
  • Peak annual rise in Change in Accured Expenses reached 822.77% in 2025, while the deepest fall reached 285.71% in 2025.
  • Tracing UPB's Change in Accured Expenses over 4 years: stood at $639000.0 in 2023, then soared by 174.65% to $1.8 million in 2024, then soared by 60.74% to $2.8 million in 2025, then slumped by 56.43% to $1.2 million in 2026.
  • The last three Change in Accured Expenses figures came in at $1.2 million (Q1 2026), $2.8 million (Q4 2025), and -$481000.0 (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Accured Expenses (Qtr)
1 Quantum Biopharma 1,216,509.61 Bn 1,216,509.61 Bn - -
2 Alterity Therapeutics 764,224.41 Bn 764,224.38 Bn - -
3 Legend Biotech 2,716.00 Bn 2,715.71 Bn 242.10 Mn -
4 Nanobiotix 2,248.83 Bn 2,248.77 Bn - -
5 Akari Therapeutics 1,951.18 Bn 1,951.17 Bn - 931,000.00
6 Vertex Pharmaceuticals 113.69 Bn 106.44 Bn 2.59 Bn 70.50 Mn
7 Evaxion A 64.16 Bn 64.14 Bn - -
8 Regeneron Pharmaceuticals 63.94 Bn 55.18 Bn 3.31 Bn 107.70 Mn
9 Alnylam Pharmaceuticals 40.13 Bn 37.12 Bn 959.66 Mn -176.03 Mn
10 Upstream Bio 454.22 Mn 454.22 Mn -3.94 Mn 1.23 Mn

Historic Data

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DateValue
Mar 31, 2026 1.23 Mn
Mar 31, 2026 1.23 Mn
Dec 31, 2025 2.82 Mn
Dec 31, 2025 2.82 Mn
Sep 30, 2025 -481,000.00
Sep 30, 2025 -481,000.00
Jun 30, 2025 3.53 Mn
Jun 30, 2025 3.53 Mn
Mar 31, 2025 -1.85 Mn
Mar 31, 2025 -1.85 Mn
Dec 31, 2024 1.76 Mn
Dec 31, 2024 1.76 Mn
Sep 30, 2024 259,000.00
Sep 30, 2024 259,000.00
Jun 30, 2024 382,000.00
Jun 30, 2024 382,000.00
Mar 31, 2024 -884,000.00
Mar 31, 2024 -884,000.00
Dec 31, 2023 639,000.00
Dec 31, 2023 639,000.00