Upstream Bio (UPB) Cash from Operations (2023 - 2026)
Upstream Bio's (UPB) quarterly Cash from Operations came in at 47852000.0 in Q1 2026, down 16.24% year-on-year from 57132884.16 in Q1 2025, and down 56.22% quarter-over-quarter from 30631000.0 in Q4 2025.
Upstream Bio (UPB) Cash from Operations (2023 - 2026) Analysis & Trends
Upstream Bio's Cash from Operations history runs 4 years deep, the most recent figure standing at 47852000.0 for Q1 2026.
- On a quarterly basis, Cash from Operations fell 16.24% year-over-year to 47852000.0 in Q1 2026; TTM through Mar 2026 was 139962000.0, a 69.09% decrease from a year earlier, with the FY2025 full-year figure at 133275000.0, down 125.23% from the prior year.
- Cash from Operations retreated to 47852000.0 in Q1 2026 per UPB's latest filing, from 30631000.0 in the prior quarter.
- Across five years, Cash from Operations topped out at 8036000.0 in Q2 2024 and bottomed at 47852000.0 in Q1 2026.
- The 4-year median for Cash from Operations is 20926000.0 (2024), against an average of 25640900.0.
- Across the five-year window, Cash from Operations plunged 388.29% in 2025 and slipped 16.24% in 2026, its largest moves.
- Year by year, Cash from Operations stood at 16110000.0 in 2023, then fell by 21.74% to 19612000.0 in 2024, then sank by 56.18% to 30631000.0 in 2025, then slumped by 56.22% to 47852000.0 in 2026.
- Per Business Quant, the three latest UPB Cash from Operations figures stand at 47852000.0 (Q1 2026), 30631000.0 (Q4 2025), and 22240000.0 (Q3 2025).
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Cash from Operations (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | -19.59 Mn |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 201.34 Mn |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | -1.53 Mn |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 1.43 Bn |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 1.08 Bn |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | - |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | -354.17 Mn |
| 10 | Upstream Bio | 347.73 Mn | 347.73 Mn | -3.94 Mn | -47.85 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -47.85 Mn |
| Mar 31, 2026 | -47.85 Mn |
| Dec 31, 2025 | -30.63 Mn |
| Dec 31, 2025 | -30.63 Mn |
| Sep 30, 2025 | -22.24 Mn |
| Sep 30, 2025 | -22.24 Mn |
| Jun 30, 2025 | -39.24 Mn |
| Jun 30, 2025 | -39.24 Mn |
| Mar 31, 2025 | -41.17 Mn |
| Mar 31, 2025 | -41.17 Mn |
| Dec 31, 2024 | -19.61 Mn |
| Dec 31, 2024 | -19.61 Mn |
| Sep 30, 2024 | -13.96 Mn |
| Sep 30, 2024 | -13.96 Mn |
| Jun 30, 2024 | -8.04 Mn |
| Jun 30, 2024 | -8.04 Mn |
| Mar 31, 2024 | -17.56 Mn |
| Mar 31, 2024 | -17.56 Mn |
| Dec 31, 2023 | -16.11 Mn |
| Dec 31, 2023 | -16.11 Mn |