Upstream Bio (UPB) Cash from Operations (2023 - 2026)
Upstream Bio (UPB) posted Cash from Operations of -$35.62 million for Q2 2026, compared with -$39.24 million a year earlier.
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Analysis
Upstream Bio (UPB) Cash from Operations (2023 - 2026) Analysis & Trends
For the trailing twelve months through Jun 30, 2026, Cash from Operations at Upstream Bio was -$136.34 million; for FY2025, it came in at -$133.28 million.
- In prior years, Upstream Bio's Cash from Operations was -$59.17 million in FY2024 and -$37.93 million in FY2023.
- Quarterly Cash from Operations has run from a low of -$47.85 million in Q1 2026 to a high of -$8.04 million in Q2 2024 over five years.
- According to Business Quant data, Cash from Operations for the three prior quarters was -$47.85 million (Q1 2026), -$30.63 million (Q4 2025) and -$22.24 million (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Cash from Ops. (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 8.62 Bn |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | 3.44 Bn |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | 5.37 Bn |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 5.88 Bn |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 4.58 Bn |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 4.00 Bn |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | 3.57 Bn |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 835.00 Mn |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 1.13 Bn |
| 10 | Upstream Bio | 288.64 Mn | 288.64 Mn | -3.29 Mn | -35.62 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -35.62 Mn |
| Mar 31, 2026 | -47.85 Mn |
| Dec 31, 2025 | -30.63 Mn |
| Sep 30, 2025 | -22.24 Mn |
| Jun 30, 2025 | -39.24 Mn |
| Mar 31, 2025 | -41.17 Mn |
| Dec 31, 2024 | -19.61 Mn |
| Sep 30, 2024 | -13.96 Mn |
| Jun 30, 2024 | -8.04 Mn |
| Mar 31, 2024 | -17.56 Mn |
| Dec 31, 2023 | -16.11 Mn |
API Access
Upstream Bio Cash from Operations API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=cash-from-operations&ticker=UPB&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "cash-from-operations", "ticker": "UPB", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=cash-from-operations&ticker=UPB&period=max&api_key=YOUR_API_KEY");
const data = await res.json();