Upstream Bio (UPB) Cash from Operations (2023 - 2026)

Upstream Bio (UPB) recorded quarterly Cash from Operations of 47852000.0 in Q1 2026, down 56.22% quarter-over-quarter from 30631000.0 in Q4 2025, and down 16.24% on a YoY basis from 57132884.16 in Q1 2025.

Upstream Bio (UPB) Cash from Operations (2023 - 2026) Analysis & Trends

Upstream Bio's Cash from Operations history runs 4 years deep, the most recent figure standing at 47852000.0 for Q1 2026.

  • In Q1 2026, Cash from Operations fell 16.24% year-over-year to 47852000.0; the TTM figure through Mar 2026 stood at 139962000.0 (down 69.09% YoY), while the FY2025 annual figure was 133275000.0, down 125.23% from the prior year.
  • Cash from Operations was 47852000.0 for Q1 2026 at Upstream Bio, down from 30631000.0 in the prior quarter.
  • In the past five years, Cash from Operations ranged from a high of 8036000.0 in Q2 2024 to a low of 47852000.0 in Q1 2026.
  • Historically, Cash from Operations has averaged 25640900.0 across 4 years, with a median of 20926000.0 in 2024.
  • The sharpest annual moves came in 2025 and 2026: Cash from Operations plunged 388.29% in 2025, then retreated 16.24% in 2026.
  • A 4-year view of Cash from Operations shows it stood at 16110000.0 in 2023, then fell by 21.74% to 19612000.0 in 2024, then tumbled by 56.18% to 30631000.0 in 2025, then plunged by 56.22% to 47852000.0 in 2026.
  • The last three Cash from Operations figures came in at 47852000.0 (Q1 2026), 30631000.0 (Q4 2025), and 22240000.0 (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Cash from Ops. (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -1.67 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -12.20 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -2.49 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.43 Bn
9 Abivax 91.96 Bn 91.96 Bn - -
10 Upstream Bio 339.03 Mn 339.03 Mn -3.94 Mn -47.85 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -47.85 Mn
Mar 31, 2026 -47.85 Mn
Dec 31, 2025 -30.63 Mn
Dec 31, 2025 -30.63 Mn
Sep 30, 2025 -22.24 Mn
Sep 30, 2025 -22.24 Mn
Jun 30, 2025 -39.24 Mn
Jun 30, 2025 -39.24 Mn
Mar 31, 2025 -41.17 Mn
Mar 31, 2025 -41.17 Mn
Dec 31, 2024 -19.61 Mn
Dec 31, 2024 -19.61 Mn
Sep 30, 2024 -13.96 Mn
Sep 30, 2024 -13.96 Mn
Jun 30, 2024 -8.04 Mn
Jun 30, 2024 -8.04 Mn
Mar 31, 2024 -17.56 Mn
Mar 31, 2024 -17.56 Mn
Dec 31, 2023 -16.11 Mn
Dec 31, 2023 -16.11 Mn