Upstream Bio UPB
NASDAQ UPB
$6.01 -0.07 (-1.15%)
As of: Sep 4, 2026 · 3:59 PM EDT

Upstream Bio (UPB) Cash from Operations (2023 - 2026)

Upstream Bio (UPB) posted quarterly Cash from Operations of 47852000.0 for Q1 2026, down 16.24% year-over-year from 57132884.16 in Q1 2025, and down 56.22% quarter-over-quarter from 30631000.0 in Q4 2025.

Analysis

Upstream Bio (UPB) Cash from Operations (2023 - 2026) Analysis & Trends

Upstream Bio's Cash from Operations history runs 4 years deep, the most recent figure standing at 47852000.0 for Q1 2026.

  • In Q1 2026, Cash from Operations fell 16.24% year-over-year to 47852000.0; the TTM figure through Mar 2026 stood at 139962000.0 (down 69.09% YoY), while the FY2025 annual figure was 133275000.0, down 125.23% from the prior year.
  • Cash from Operations for Q1 2026 stood at 47852000.0, down from 30631000.0 in the prior quarter.
  • The five-year high for Cash from Operations was 8036000.0 in Q2 2024, with the low at 47852000.0 in Q1 2026.
  • The 4-year median for Cash from Operations is 20926000.0 (2024), against an average of 25640900.0.
  • The sharpest annual moves came in 2025 and 2026: Cash from Operations tumbled 388.29% in 2025, then fell 16.24% in 2026.
  • Upstream Bio's Cash from Operations stood at 16110000.0 in 2023, then declined by 21.74% to 19612000.0 in 2024, then slumped by 56.18% to 30631000.0 in 2025, then tumbled by 56.22% to 47852000.0 in 2026.
  • Business Quant data shows UPB's Cash from Operations at 47852000.0 in Q1 2026, 30631000.0 in Q4 2025, and 22240000.0 in Q3 2025.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Cash from Operations (Qtr)
1 Vertex Pharmaceuticals 138.47 Bn 130.62 Bn 2.84 Bn 1.13 Bn
2 Regeneron Pharmaceuticals 85.18 Bn 77.19 Bn 3.93 Bn 813.00 Mn
3 Argenx Se 63.38 Bn 58.19 Bn 1.37 Bn -
4 Moderna 58.09 Bn 52.95 Bn 52.00 Mn -526.00 Mn
5 Revolution Medicines 44.33 Bn 44.33 Bn - -387.32 Mn
6 BeOne Medicines 40.02 Bn 34.92 Bn 1.53 Bn 462.82 Mn
7 Alnylam Pharmaceuticals 35.57 Bn 32.27 Bn 992.69 Mn 326.72 Mn
8 Royalty Pharma 28.45 Bn 27.61 Bn - 728.46 Mn
9 Insmed 27.48 Bn 26.32 Bn 358.27 Mn -88.83 Mn
10 Upstream Bio 327.95 Mn 327.95 Mn -3.29 Mn -35.62 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -35.62 Mn
Mar 31, 2026 -47.85 Mn
Dec 31, 2025 -30.63 Mn
Sep 30, 2025 -22.24 Mn
Jun 30, 2025 -39.24 Mn
Mar 31, 2025 -41.17 Mn
Dec 31, 2024 -19.61 Mn
Sep 30, 2024 -13.96 Mn
Jun 30, 2024 -8.04 Mn
Mar 31, 2024 -17.56 Mn
Dec 31, 2023 -16.11 Mn