Upstream Bio (UPB) Cash from Operations (2023 - 2026)
Upstream Bio (UPB) recorded quarterly Cash from Operations of 47852000.0 in Q1 2026, down 56.22% quarter-over-quarter from 30631000.0 in Q4 2025, and down 16.24% on a YoY basis from 57132884.16 in Q1 2025.
Upstream Bio (UPB) Cash from Operations (2023 - 2026) Analysis & Trends
Upstream Bio's Cash from Operations history runs 4 years deep, the most recent figure standing at 47852000.0 for Q1 2026.
- In Q1 2026, Cash from Operations fell 16.24% year-over-year to 47852000.0; the TTM figure through Mar 2026 stood at 139962000.0 (down 69.09% YoY), while the FY2025 annual figure was 133275000.0, down 125.23% from the prior year.
- Cash from Operations was 47852000.0 for Q1 2026 at Upstream Bio, down from 30631000.0 in the prior quarter.
- In the past five years, Cash from Operations ranged from a high of 8036000.0 in Q2 2024 to a low of 47852000.0 in Q1 2026.
- Historically, Cash from Operations has averaged 25640900.0 across 4 years, with a median of 20926000.0 in 2024.
- The sharpest annual moves came in 2025 and 2026: Cash from Operations plunged 388.29% in 2025, then retreated 16.24% in 2026.
- A 4-year view of Cash from Operations shows it stood at 16110000.0 in 2023, then fell by 21.74% to 19612000.0 in 2024, then tumbled by 56.18% to 30631000.0 in 2025, then plunged by 56.22% to 47852000.0 in 2026.
- The last three Cash from Operations figures came in at 47852000.0 (Q1 2026), 30631000.0 (Q4 2025), and 22240000.0 (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Cash from Ops. (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | -1.67 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -12.20 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -2.49 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 1.43 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | - |
| 10 | Upstream Bio | 339.03 Mn | 339.03 Mn | -3.94 Mn | -47.85 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -47.85 Mn |
| Mar 31, 2026 | -47.85 Mn |
| Dec 31, 2025 | -30.63 Mn |
| Dec 31, 2025 | -30.63 Mn |
| Sep 30, 2025 | -22.24 Mn |
| Sep 30, 2025 | -22.24 Mn |
| Jun 30, 2025 | -39.24 Mn |
| Jun 30, 2025 | -39.24 Mn |
| Mar 31, 2025 | -41.17 Mn |
| Mar 31, 2025 | -41.17 Mn |
| Dec 31, 2024 | -19.61 Mn |
| Dec 31, 2024 | -19.61 Mn |
| Sep 30, 2024 | -13.96 Mn |
| Sep 30, 2024 | -13.96 Mn |
| Jun 30, 2024 | -8.04 Mn |
| Jun 30, 2024 | -8.04 Mn |
| Mar 31, 2024 | -17.56 Mn |
| Mar 31, 2024 | -17.56 Mn |
| Dec 31, 2023 | -16.11 Mn |
| Dec 31, 2023 | -16.11 Mn |