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Upstream Bio (UPB) Cash from Operations: 2023-2025

Historic Cash from Operations for Upstream Bio (UPB) over the last 2 years, with Sep 2025 value amounting to -$22.2 million.

  • Upstream Bio's Cash from Operations fell 59.29% to -$22.2 million in Q3 2025 from the same period last year, while for Sep 2025 it was -$122.3 million, marking a year-over-year decrease of 119.61%. This contributed to the annual value of -$59.2 million for FY2024, which is 56.02% down from last year.
  • Latest data reveals that Upstream Bio reported Cash from Operations of -$22.2 million as of Q3 2025, which was up 43.32% from -$39.2 million recorded in Q2 2025.
  • Upstream Bio's 5-year Cash from Operations high stood at -$8.0 million for Q2 2024, and its period low was -$41.2 million during Q1 2025.
  • Its 3-year average for Cash from Operations is -$22.2 million, with a median of -$18.6 million in 2024.
  • Data for Upstream Bio's Cash from Operations shows a maximum YoY slumped of 388.29% (in 2025) over the last 5 years.
  • Upstream Bio's Cash from Operations (Quarterly) stood at -$16.1 million in 2023, then dropped by 21.74% to -$19.6 million in 2024, then slumped by 59.29% to -$22.2 million in 2025.
  • Its Cash from Operations stands at -$22.2 million for Q3 2025, versus -$39.2 million for Q2 2025 and -$41.2 million for Q1 2025.