Upstream Bio (UPB) Cash from Investing Activities (2023 - 2026)

Upstream Bio (UPB) recorded quarterly Cash from Investing Activities of $42.4 million in Q1 2026, down 28.06% quarter-over-quarter from $58.9 million in Q4 2025, and up 119.87% on a YoY basis from $19.3 million in Q1 2025.

Upstream Bio (UPB) Cash from Investing Activities (2023 - 2026) Analysis & Trends

Upstream Bio's Cash from Investing Activities history runs 4 years deep, the most recent figure standing at $42.4 million for Q1 2026.

  • In Q1 2026, Cash from Investing Activities rose 119.87% year-over-year to $42.4 million; the TTM figure through Mar 2026 stood at $162.3 million (up 156.61% YoY), while the FY2025 annual figure was -$93.5 million, down 57.15% from the prior year.
  • Cash from Investing Activities was $42.4 million for Q1 2026 at Upstream Bio, down from $58.9 million in the prior quarter.
  • In the past five years, Cash from Investing Activities ranged from a high of $58.9 million in Q4 2025 to a low of -$213.4 million in Q1 2025.
  • Historically, Cash from Investing Activities has averaged -$11.6 million across 4 years, with a median of $13.3 million in 2024.
  • Biggest YoY gain for Cash from Investing Activities was 3319.87% in 2025; the steepest drop was 1640.43% in 2025.
  • A 4-year view of Cash from Investing Activities shows it stood at -$5.2 million in 2023, then soared by 899.47% to $41.9 million in 2024, then surged by 40.65% to $58.9 million in 2025, then decreased by 28.06% to $42.4 million in 2026.
  • The last three Cash from Investing Activities figures came in at $42.4 million (Q1 2026), $58.9 million (Q4 2025), and $48.2 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Cash from Investing Activities (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -2.89 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 638.50 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn -431.90 Mn
9 Abivax 91.96 Bn 91.96 Bn - 579,519.10
10 Upstream Bio 339.03 Mn 339.03 Mn -3.94 Mn 42.40 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 42.40 Mn
Mar 31, 2026 42.40 Mn
Dec 31, 2025 58.94 Mn
Dec 31, 2025 58.94 Mn
Sep 30, 2025 48.19 Mn
Sep 30, 2025 48.19 Mn
Jun 30, 2025 12.77 Mn
Jun 30, 2025 12.77 Mn
Mar 31, 2025 -213.38 Mn
Mar 31, 2025 -213.38 Mn
Dec 31, 2024 41.91 Mn
Dec 31, 2024 41.91 Mn
Sep 30, 2024 1.41 Mn
Sep 30, 2024 1.41 Mn
Jun 30, 2024 -116.65 Mn
Jun 30, 2024 -116.65 Mn
Mar 31, 2024 13.85 Mn
Mar 31, 2024 13.85 Mn
Dec 31, 2023 -5.24 Mn
Dec 31, 2023 -5.24 Mn