Upstream Bio (UPB) Cash from Investing Activities (2023 - 2026)
Upstream Bio's (UPB) quarterly Cash from Investing Activities came in at $42.4 million in Q1 2026, up 119.87% year-on-year from $19.3 million in Q1 2025, and down 28.06% quarter-over-quarter from $58.9 million in Q4 2025.
Upstream Bio (UPB) Cash from Investing Activities (2023 - 2026) Analysis & Trends
Upstream Bio's Cash from Investing Activities history runs 4 years deep, the most recent figure standing at $42.4 million for Q1 2026.
- On a quarterly basis, Cash from Investing Activities rose 119.87% year-over-year to $42.4 million in Q1 2026; TTM through Mar 2026 was $162.3 million, a 156.61% increase from a year earlier, with the FY2025 full-year figure at -$93.5 million, down 57.15% from the prior year.
- Cash from Investing Activities eased to $42.4 million in Q1 2026 per UPB's latest filing, from $58.9 million in the prior quarter.
- Across five years, Cash from Investing Activities topped out at $58.9 million in Q4 2025 and bottomed at -$213.4 million in Q1 2025.
- The 4-year median for Cash from Investing Activities is $13.3 million (2024), against an average of -$11.6 million.
- Biggest YoY gain for Cash from Investing Activities was 3319.87% in 2025; the steepest drop was 1640.43% in 2025.
- Year by year, Cash from Investing Activities stood at -$5.2 million in 2023, then soared by 899.47% to $41.9 million in 2024, then surged by 40.65% to $58.9 million in 2025, then decreased by 28.06% to $42.4 million in 2026.
- Per Business Quant, the three latest UPB Cash from Investing Activities figures stand at $42.4 million (Q1 2026), $58.9 million (Q4 2025), and $48.2 million (Q3 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Cash from Investing Activities (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 67,072.09 Bn | 67,072.09 Bn | - | - |
| 2 | Nanobiotix | 1,894.61 Bn | 1,894.55 Bn | - | - |
| 3 | Akari Therapeutics | 1,014.18 Bn | 1,014.18 Bn | - | - |
| 4 | BeOne Medicines | 471.64 Bn | 466.85 Bn | 1.35 Bn | -45.51 Mn |
| 5 | Vertex Pharmaceuticals | 121.72 Bn | 114.47 Bn | 2.59 Bn | -431.90 Mn |
| 6 | Regeneron Pharmaceuticals | 68.28 Bn | 59.52 Bn | 3.31 Bn | -428.90 Mn |
| 7 | Belite Bio | 61.40 Bn | 61.40 Bn | - | - |
| 8 | Argenx Se | 56.94 Bn | 56.94 Bn | 1.18 Bn | - |
| 9 | Revolution Medicines | 37.37 Bn | 37.37 Bn | - | 172.62 Mn |
| 10 | Upstream Bio | 343.65 Mn | 343.65 Mn | -3.94 Mn | 42.40 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 42.40 Mn |
| Mar 31, 2026 | 42.40 Mn |
| Dec 31, 2025 | 58.94 Mn |
| Dec 31, 2025 | 58.94 Mn |
| Sep 30, 2025 | 48.19 Mn |
| Sep 30, 2025 | 48.19 Mn |
| Jun 30, 2025 | 12.77 Mn |
| Jun 30, 2025 | 12.77 Mn |
| Mar 31, 2025 | -213.38 Mn |
| Mar 31, 2025 | -213.38 Mn |
| Dec 31, 2024 | 41.91 Mn |
| Dec 31, 2024 | 41.91 Mn |
| Sep 30, 2024 | 1.41 Mn |
| Sep 30, 2024 | 1.41 Mn |
| Jun 30, 2024 | -116.65 Mn |
| Jun 30, 2024 | -116.65 Mn |
| Mar 31, 2024 | 13.85 Mn |
| Mar 31, 2024 | 13.85 Mn |
| Dec 31, 2023 | -5.24 Mn |
| Dec 31, 2023 | -5.24 Mn |