Upstream Bio (UPB) Cash from Investing Activities (2023 - 2026)
Upstream Bio (UPB) recorded quarterly Cash from Investing Activities of $42.4 million in Q1 2026, down 28.06% quarter-over-quarter from $58.9 million in Q4 2025, and up 119.87% on a YoY basis from $19.3 million in Q1 2025.
Upstream Bio (UPB) Cash from Investing Activities (2023 - 2026) Analysis & Trends
Upstream Bio's Cash from Investing Activities history runs 4 years deep, the most recent figure standing at $42.4 million for Q1 2026.
- In Q1 2026, Cash from Investing Activities rose 119.87% year-over-year to $42.4 million; the TTM figure through Mar 2026 stood at $162.3 million (up 156.61% YoY), while the FY2025 annual figure was -$93.5 million, down 57.15% from the prior year.
- Cash from Investing Activities was $42.4 million for Q1 2026 at Upstream Bio, down from $58.9 million in the prior quarter.
- In the past five years, Cash from Investing Activities ranged from a high of $58.9 million in Q4 2025 to a low of -$213.4 million in Q1 2025.
- Historically, Cash from Investing Activities has averaged -$11.6 million across 4 years, with a median of $13.3 million in 2024.
- Biggest YoY gain for Cash from Investing Activities was 3319.87% in 2025; the steepest drop was 1640.43% in 2025.
- A 4-year view of Cash from Investing Activities shows it stood at -$5.2 million in 2023, then soared by 899.47% to $41.9 million in 2024, then surged by 40.65% to $58.9 million in 2025, then decreased by 28.06% to $42.4 million in 2026.
- The last three Cash from Investing Activities figures came in at $42.4 million (Q1 2026), $58.9 million (Q4 2025), and $48.2 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Cash from Investing Activities (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | -2.89 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | 638.50 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | - |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | -431.90 Mn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | 579,519.10 |
| 10 | Upstream Bio | 339.03 Mn | 339.03 Mn | -3.94 Mn | 42.40 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 42.40 Mn |
| Mar 31, 2026 | 42.40 Mn |
| Dec 31, 2025 | 58.94 Mn |
| Dec 31, 2025 | 58.94 Mn |
| Sep 30, 2025 | 48.19 Mn |
| Sep 30, 2025 | 48.19 Mn |
| Jun 30, 2025 | 12.77 Mn |
| Jun 30, 2025 | 12.77 Mn |
| Mar 31, 2025 | -213.38 Mn |
| Mar 31, 2025 | -213.38 Mn |
| Dec 31, 2024 | 41.91 Mn |
| Dec 31, 2024 | 41.91 Mn |
| Sep 30, 2024 | 1.41 Mn |
| Sep 30, 2024 | 1.41 Mn |
| Jun 30, 2024 | -116.65 Mn |
| Jun 30, 2024 | -116.65 Mn |
| Mar 31, 2024 | 13.85 Mn |
| Mar 31, 2024 | 13.85 Mn |
| Dec 31, 2023 | -5.24 Mn |
| Dec 31, 2023 | -5.24 Mn |