Tyra Biosciences (TYRA) Return on Equity [ROE] (2021 - 2026)
Tyra Biosciences (TYRA) recorded Return on Equity [ROE] of -40.09% in Q2 2026, down 6.26 percentage points from -33.83% a year earlier but up 0.46 percentage points from the prior quarter.
Powered by 
Analysis
Tyra Biosciences (TYRA) Return on Equity [ROE] (2021 - 2026) Analysis & Trends
For FY2025, Tyra Biosciences reported Return on Equity [ROE] of -39.83%, down 8.23 percentage points from FY2024.
- Annual Return on Equity [ROE] has declined for four straight years, with a four-year change of -21.59 percentage points (FY2021 to FY2025).
- Across earlier years, Return on Equity [ROE] came in at -31.60% in FY2024 (-1.67 pp), -29.92% in FY2023 (-10.17 pp), -19.76% in FY2022 (-1.52 pp) and -18.24% in FY2021.
- Quarterly Return on Equity [ROE] has ranged from -44.45% in Q4 2025 to -8.59% in Q4 2021 over the past five years.
- On a year-over-year basis, Return on Equity [ROE] has declined for six consecutive quarters, with an average year-over-year change of -7.35 percentage points over the last eight quarters.
- Peak year-over-year performance for Return on Equity [ROE] in the last five years was a gain of 7.91 percentage points in Q4 2024, against a drop of 19.93 percentage points in Q4 2025 at the low end.
- Per Business Quant, the preceding three quarters came in at -40.54% (Q1 2026), -44.45% (Q4 2025) and -38.34% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,348.13 Bn | 1,321.74 Bn | 20.46 Bn | 74.39% |
| 2 | Johnson & Johnson | 675.90 Bn | 595.76 Bn | 17.30 Bn | 19.33% |
| 3 | AbbVie | 519.45 Bn | 487.50 Bn | 13.12 Bn | - |
| 4 | Merck | 364.95 Bn | 327.95 Bn | 13.19 Bn | 5.63% |
| 5 | Novartis Ag | 311.58 Bn | 285.16 Bn | - | - |
| 6 | Astrazeneca | 289.34 Bn | 262.94 Bn | 13.26 Bn | 21.60% |
| 7 | Amgen | 251.64 Bn | 203.30 Bn | 7.58 Bn | 72.13% |
| 8 | Gilead Sciences | 212.05 Bn | 187.07 Bn | 6.73 Bn | -31.17% |
| 9 | Pfizer | 167.35 Bn | 115.00 Bn | 12.56 Bn | 4.66% |
| 10 | Tyra Biosciences | 1.45 Bn | 758.54 Mn | - | -32.78% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Sep 30, 2026 | -32.78% |
| Jun 30, 2026 | -40.36% |
| Mar 31, 2026 | -40.72% |
| Dec 31, 2025 | -44.59% |
| Sep 30, 2025 | -38.79% |
| Jun 30, 2025 | -33.63% |
| Mar 31, 2025 | -28.72% |
| Dec 31, 2024 | -24.41% |
| Sep 30, 2024 | -22.21% |
| Jun 30, 2024 | -21.17% |
| Mar 31, 2024 | -25.40% |
| Dec 31, 2023 | -32.25% |
| Sep 30, 2023 | -25.68% |
| Jun 30, 2023 | -20.74% |
| Mar 31, 2023 | -20.66% |
| Dec 31, 2022 | -21.03% |
| Sep 30, 2022 | -19.15% |
| Jun 30, 2022 | -16.30% |
| Mar 31, 2022 | -12.44% |
| Dec 31, 2021 | -8.59% |
API Access
Tyra Biosciences Return on Equity [ROE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=TYRA&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-equity-[roe]", "ticker": "TYRA", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=TYRA&period=max&api_key=YOUR_API_KEY");
const data = await res.json();