Spyre Therapeutics (SYRE) Return on Equity [ROE] (2016 - 2026)
Spyre Therapeutics (SYRE) posted Return on Equity [ROE] of -24.51% for Q3 2026, up 8.19 percentage points from -32.71% a year earlier but down 4.32 percentage points from the prior quarter.
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Analysis
Spyre Therapeutics (SYRE) Return on Equity [ROE] (2016 - 2026) Analysis & Trends
For FY2025, Spyre Therapeutics' Return on Equity [ROE] came in at -25.17%, up 34.11 percentage points from FY2024.
- Annual Return on Equity [ROE] shows a five-year change of +55.75 percentage points (FY2020 to FY2025).
- In prior years, Spyre Therapeutics' Return on Equity [ROE] was -59.28% in FY2024 (+229.89 pp), -289.17% in FY2023 (-164.30 pp), -124.87% in FY2022 (-66.06 pp) and -58.81% in FY2021 (+22.12 pp).
- Quarterly Return on Equity [ROE] has run from a low of -216.62% in Q1 2024 to a high of -20.19% in Q2 2026 over five years.
- On a year-over-year basis, Return on Equity [ROE] has increased in each of the last seven quarters, with an average year-over-year change of +42.94 percentage points over the last seven quarters.
- The strongest year-over-year quarter for Return on Equity [ROE] in the past five years was Q1 2025, with a gain of 174.85 percentage points; the weakest was Q1 2023, with a drop of 86.41 percentage points.
- According to Business Quant data, Return on Equity [ROE] for the three prior quarters was -20.19% (Q2 2026), -25.89% (Q1 2026) and -26.52% (Q4 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,348.13 Bn | 1,321.74 Bn | 20.46 Bn | 74.39% |
| 2 | Johnson & Johnson | 675.90 Bn | 595.76 Bn | 17.30 Bn | 19.33% |
| 3 | AbbVie | 519.45 Bn | 487.50 Bn | 13.12 Bn | - |
| 4 | Merck | 364.95 Bn | 327.95 Bn | 13.19 Bn | 5.63% |
| 5 | Novartis Ag | 311.58 Bn | 285.16 Bn | - | - |
| 6 | Astrazeneca | 289.34 Bn | 262.94 Bn | 13.26 Bn | 21.60% |
| 7 | Amgen | 251.64 Bn | 203.30 Bn | 7.58 Bn | 72.13% |
| 8 | Gilead Sciences | 212.05 Bn | 187.07 Bn | 6.73 Bn | -31.17% |
| 9 | Pfizer | 167.35 Bn | 115.00 Bn | 12.56 Bn | 4.66% |
| 10 | Spyre Therapeutics | 9.40 Bn | 5.68 Bn | - | -24.51% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Sep 30, 2026 | -24.51% |
| Jun 30, 2026 | -20.19% |
| Mar 31, 2026 | -25.89% |
| Dec 31, 2025 | -26.52% |
| Sep 30, 2025 | -32.71% |
| Jun 30, 2025 | -44.08% |
| Mar 31, 2025 | -41.77% |
| Dec 31, 2024 | -49.22% |
| Sep 30, 2024 | -61.25% |
| Jun 30, 2024 | -70.63% |
| Mar 31, 2024 | -216.62% |
| Mar 31, 2023 | -185.34% |
| Dec 31, 2022 | -142.23% |
| Sep 30, 2022 | -112.63% |
| Jun 30, 2022 | -120.03% |
| Mar 31, 2022 | -98.93% |
| Dec 31, 2021 | -70.71% |
| Sep 30, 2021 | -61.54% |
| Jun 30, 2021 | -54.18% |
| Mar 31, 2021 | -60.97% |
API Access
Spyre Therapeutics Return on Equity [ROE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=SYRE&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-equity-[roe]", "ticker": "SYRE", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=SYRE&period=max&api_key=YOUR_API_KEY");
const data = await res.json();