Spyre Therapeutics (SYRE) Return on Equity [ROE] (2016 - 2026)
Spyre Therapeutics (SYRE) posted Return on Equity [ROE] of -20.19% for Q2 2026, up 23.88 percentage points from -44.08% a year earlier and up 5.70 percentage points from the prior quarter.
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Analysis
Spyre Therapeutics (SYRE) Return on Equity [ROE] (2016 - 2026) Analysis & Trends
For FY2025, Spyre Therapeutics' Return on Equity [ROE] came in at -25.17%, up 34.11 percentage points from FY2024.
- Annual Return on Equity [ROE] shows a five-year change of +55.75 percentage points (FY2020 to FY2025).
- In prior years, Spyre Therapeutics' Return on Equity [ROE] was -59.28% in FY2024 (+229.89 pp), -289.17% in FY2023 (-164.30 pp), -124.87% in FY2022 (-66.06 pp) and -58.81% in FY2021 (+22.12 pp).
- The Q2 2026 figure stands as the highest quarterly Return on Equity [ROE] in data going back to Q2 2016.
- On a year-over-year basis, Return on Equity [ROE] has increased in each of the last six quarters, with an average year-over-year change of +48.73 percentage points over the last six quarters.
- The strongest year-over-year quarter for Return on Equity [ROE] in the past five years was Q1 2025, with a gain of 174.85 percentage points; the weakest was Q1 2023, with a drop of 86.41 percentage points.
- According to Business Quant data, Return on Equity [ROE] for the three prior quarters was -25.89% (Q1 2026), -26.52% (Q4 2025) and -32.71% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROE (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 25.32% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | - |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | 7.21% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 84.40% |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 21.39% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 83.75% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -18.38% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 4.97% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 22.24% |
| 10 | Spyre Therapeutics | 7.84 Bn | 7.84 Bn | - | -20.19% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -20.19% |
| Mar 31, 2026 | -25.89% |
| Dec 31, 2025 | -26.52% |
| Sep 30, 2025 | -32.71% |
| Jun 30, 2025 | -44.08% |
| Mar 31, 2025 | -41.77% |
| Dec 31, 2024 | -49.22% |
| Sep 30, 2024 | -61.25% |
| Jun 30, 2024 | -70.63% |
| Mar 31, 2024 | -216.62% |
| Mar 31, 2023 | -185.34% |
| Dec 31, 2022 | -142.23% |
| Sep 30, 2022 | -112.63% |
| Jun 30, 2022 | -120.03% |
| Mar 31, 2022 | -98.93% |
| Dec 31, 2021 | -70.71% |
| Sep 30, 2021 | -61.54% |
| Jun 30, 2021 | -54.18% |
| Mar 31, 2021 | -60.97% |
| Dec 31, 2020 | -58.59% |
API Access
Spyre Therapeutics Return on Equity [ROE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=SYRE&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-equity-[roe]", "ticker": "SYRE", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=SYRE&period=max&api_key=YOUR_API_KEY");
const data = await res.json();