Spyre Therapeutics (SYRE) Return on Capital Employed [ROCE] (2016 - 2026)
Spyre Therapeutics' Return on Capital Employed [ROCE] was -22.24% in Q2 2026, up 22.78 percentage points from -45.02% a year earlier and up 7.16 percentage points from the prior quarter.
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Analysis
Spyre Therapeutics (SYRE) Return on Capital Employed [ROCE] (2016 - 2026) Analysis & Trends
For FY2025, Return on Capital Employed [ROCE] at Spyre Therapeutics came in at -33.03%, up 16.50 percentage points from FY2024.
- Return on Capital Employed [ROCE] shows a five-year change of +43.87 percentage points (FY2020 to FY2025).
- In earlier years, Return on Capital Employed [ROCE] was -49.53% in FY2024 (+89.31 pp), -138.84% in FY2023 (-27.11 pp), -111.73% in FY2022 (-54.96 pp) and -56.78% in FY2021 (+20.12 pp).
- The Q2 2026 figure marks the highest quarterly Return on Capital Employed [ROCE] in data going back to Q1 2016.
- Compared with a year earlier, Return on Capital Employed [ROCE] has increased for four straight quarters, with an average year-over-year change of +24.40 percentage points over the last eight quarters.
- The best year-over-year quarter for Return on Capital Employed [ROCE] over five years was Q1 2024 (a gain of 88.05 percentage points); the worst was Q1 2023 (a drop of 71.42 percentage points).
- Per Business Quant data, SYRE's Return on Capital Employed [ROCE] in the three quarters before Q2 2026 was -29.41% (Q1 2026), -35.98% (Q4 2025) and -44.94% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,076.25 Bn | 1,044.84 Bn | 19.71 Bn | 46.74% |
| 2 | Johnson & Johnson | 617.18 Bn | 535.70 Bn | 17.26 Bn | 17.83% |
| 3 | AbbVie | 464.58 Bn | 437.73 Bn | 12.70 Bn | 17.92% |
| 4 | Merck | 356.04 Bn | 310.47 Bn | 12.21 Bn | 6.28% |
| 5 | Novartis Ag | 269.07 Bn | 224.94 Bn | 11.24 Bn | 19.32% |
| 6 | Astrazeneca | 243.21 Bn | 216.77 Bn | 12.86 Bn | 9.54% |
| 7 | Amgen | 217.88 Bn | 173.28 Bn | 7.24 Bn | 16.66% |
| 8 | Gilead Sciences | 179.62 Bn | 153.74 Bn | 6.22 Bn | -5.97% |
| 9 | Pfizer | 158.45 Bn | 105.40 Bn | 10.94 Bn | 11.86% |
| 10 | Spyre Therapeutics | 8.21 Bn | 8.21 Bn | - | -22.24% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -22.24% |
| Mar 31, 2026 | -29.41% |
| Dec 31, 2025 | -35.98% |
| Sep 30, 2025 | -44.94% |
| Jun 30, 2025 | -45.02% |
| Mar 31, 2025 | -41.35% |
| Dec 31, 2024 | -45.27% |
| Sep 30, 2024 | -52.08% |
| Jun 30, 2024 | -35.52% |
| Mar 31, 2024 | -72.94% |
| Dec 31, 2023 | -99.88% |
| Sep 30, 2023 | -119.40% |
| Mar 31, 2023 | -160.99% |
| Dec 31, 2022 | -127.11% |
| Sep 30, 2022 | -105.65% |
| Jun 30, 2022 | -110.78% |
| Mar 31, 2022 | -89.57% |
| Dec 31, 2021 | -66.08% |
| Sep 30, 2021 | -57.81% |
| Jun 30, 2021 | -48.86% |
API Access
Spyre Therapeutics Return on Capital Employed [ROCE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=SYRE&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-capital-employed-[roce]", "ticker": "SYRE", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=SYRE&period=max&api_key=YOUR_API_KEY");
const data = await res.json();