Spyre Therapeutics (SYRE) Return on Capital Employed [ROCE] (2016 - 2026)
Spyre Therapeutics' Return on Capital Employed [ROCE] was -22.82% in Q3 2026, up 22.11 percentage points from -44.94% a year earlier but down 0.58 percentage points from the prior quarter.
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Analysis
Spyre Therapeutics (SYRE) Return on Capital Employed [ROCE] (2016 - 2026) Analysis & Trends
For FY2025, Return on Capital Employed [ROCE] at Spyre Therapeutics came in at -33.03%, up 16.50 percentage points from FY2024.
- Return on Capital Employed [ROCE] shows a five-year change of +43.87 percentage points (FY2020 to FY2025).
- In earlier years, Return on Capital Employed [ROCE] was -49.53% in FY2024 (+89.31 pp), -138.84% in FY2023 (-27.11 pp), -111.73% in FY2022 (-54.96 pp) and -56.78% in FY2021 (+20.12 pp).
- Quarterly Return on Capital Employed [ROCE] has moved between -160.99% (Q1 2023) and -22.24% (Q2 2026) over five years.
- Compared with a year earlier, Return on Capital Employed [ROCE] has increased for five straight quarters, with an average year-over-year change of +18.75 percentage points over the last eight quarters.
- The best year-over-year quarter for Return on Capital Employed [ROCE] over five years was Q1 2024 (a gain of 88.05 percentage points); the worst was Q1 2023 (a drop of 71.42 percentage points).
- Per Business Quant data, SYRE's Return on Capital Employed [ROCE] in the three quarters before Q3 2026 was -22.24% (Q2 2026), -29.41% (Q1 2026) and -35.98% (Q4 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,348.13 Bn | 1,321.74 Bn | 20.46 Bn | 35.41% |
| 2 | Johnson & Johnson | 675.90 Bn | 595.76 Bn | 17.30 Bn | 17.52% |
| 3 | AbbVie | 519.45 Bn | 487.50 Bn | 13.12 Bn | 21.60% |
| 4 | Merck | 364.95 Bn | 327.95 Bn | 13.19 Bn | 4.65% |
| 5 | Novartis Ag | 311.58 Bn | 285.16 Bn | - | - |
| 6 | Astrazeneca | 289.34 Bn | 262.94 Bn | 13.26 Bn | 9.91% |
| 7 | Amgen | 251.64 Bn | 203.30 Bn | 7.58 Bn | 17.37% |
| 8 | Gilead Sciences | 212.05 Bn | 187.07 Bn | 6.73 Bn | -6.15% |
| 9 | Pfizer | 167.35 Bn | 115.00 Bn | 12.56 Bn | 11.32% |
| 10 | Spyre Therapeutics | 9.40 Bn | 5.68 Bn | - | -22.82% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Sep 30, 2026 | -22.82% |
| Jun 30, 2026 | -22.24% |
| Mar 31, 2026 | -29.41% |
| Dec 31, 2025 | -35.98% |
| Sep 30, 2025 | -44.94% |
| Jun 30, 2025 | -45.02% |
| Mar 31, 2025 | -41.35% |
| Dec 31, 2024 | -45.27% |
| Sep 30, 2024 | -52.08% |
| Jun 30, 2024 | -35.52% |
| Mar 31, 2024 | -72.94% |
| Dec 31, 2023 | -99.88% |
| Sep 30, 2023 | -119.40% |
| Mar 31, 2023 | -160.99% |
| Dec 31, 2022 | -127.11% |
| Sep 30, 2022 | -105.65% |
| Jun 30, 2022 | -110.78% |
| Mar 31, 2022 | -89.57% |
| Dec 31, 2021 | -66.08% |
| Sep 30, 2021 | -57.81% |
API Access
Spyre Therapeutics Return on Capital Employed [ROCE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=SYRE&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-capital-employed-[roce]", "ticker": "SYRE", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=SYRE&period=max&api_key=YOUR_API_KEY");
const data = await res.json();