Spyre Therapeutics (SYRE) Return on Assets [ROA] (2016 - 2026)
Spyre Therapeutics' Return on Assets [ROA] came in at -23.22% for Q3 2026, up 5.33 percentage points from -28.55% a year earlier but down 4.75 percentage points from the prior quarter.
Powered by 
Analysis
Spyre Therapeutics (SYRE) Return on Assets [ROA] (2016 - 2026) Analysis & Trends
For FY2025, Spyre Therapeutics' Return on Assets [ROA] was -22.39%, up 21.39 percentage points from FY2024.
- Return on Assets [ROA] carries a five-year change of +43.70 percentage points (FY2020 to FY2025).
- Going back by year, Return on Assets [ROA] was -43.78% in FY2024 (+120.28 pp), -164.06% in FY2023 (-71.48 pp), -92.58% in FY2022 (-44.11 pp) and -48.46% in FY2021 (+17.62 pp).
- The five-year range for quarterly Return on Assets [ROA] is -184.17% (Q2 2023) to -18.47% (Q2 2026).
- Year-over-year, Return on Assets [ROA] has increased for 11 consecutive quarters, with an average year-over-year change of +26.56 percentage points over the last eight quarters.
- The fastest year-over-year change in Return on Assets [ROA] over five years came in Q2 2024 (a gain of 143.90 percentage points), and the weakest in Q2 2023 (a drop of 92.00 percentage points).
- Business Quant data shows SYRE's Return on Assets [ROA] at -18.47% (Q2 2026), -23.28% (Q1 2026) and -24.21% (Q4 2025) in the three quarters before Q3 2026.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROA (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,348.13 Bn | 1,321.74 Bn | 20.46 Bn | 19.00% |
| 2 | Johnson & Johnson | 675.90 Bn | 595.76 Bn | 17.30 Bn | 8.08% |
| 3 | AbbVie | 519.45 Bn | 487.50 Bn | 13.12 Bn | 7.32% |
| 4 | Merck | 364.95 Bn | 327.95 Bn | 13.19 Bn | 1.87% |
| 5 | Novartis Ag | 311.58 Bn | 285.16 Bn | - | - |
| 6 | Astrazeneca | 289.34 Bn | 262.94 Bn | 13.26 Bn | 9.36% |
| 7 | Amgen | 251.64 Bn | 203.30 Bn | 7.58 Bn | 9.80% |
| 8 | Gilead Sciences | 212.05 Bn | 187.07 Bn | 6.73 Bn | -7.67% |
| 9 | Pfizer | 167.35 Bn | 115.00 Bn | 12.56 Bn | 2.00% |
| 10 | Spyre Therapeutics | 9.40 Bn | 5.68 Bn | - | -23.22% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Sep 30, 2026 | -23.22% |
| Jun 30, 2026 | -18.47% |
| Mar 31, 2026 | -23.28% |
| Dec 31, 2025 | -24.21% |
| Sep 30, 2025 | -28.55% |
| Jun 30, 2025 | -37.31% |
| Mar 31, 2025 | -35.46% |
| Dec 31, 2024 | -40.41% |
| Sep 30, 2024 | -50.14% |
| Jun 30, 2024 | -40.27% |
| Mar 31, 2024 | -87.82% |
| Dec 31, 2023 | -123.39% |
| Sep 30, 2023 | -130.63% |
| Jun 30, 2023 | -184.17% |
| Mar 31, 2023 | -125.89% |
| Dec 31, 2022 | -103.02% |
| Sep 30, 2022 | -86.18% |
| Jun 30, 2022 | -92.18% |
| Mar 31, 2022 | -74.59% |
| Dec 31, 2021 | -55.04% |
API Access
Spyre Therapeutics Return on Assets [ROA] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-assets-%5Broa%5D&ticker=SYRE&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-assets-[roa]", "ticker": "SYRE", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-assets-%5Broa%5D&ticker=SYRE&period=max&api_key=YOUR_API_KEY");
const data = await res.json();