Spyre Therapeutics (SYRE) Return on Assets [ROA] (2016 - 2026)
Spyre Therapeutics' Return on Assets [ROA] came in at -18.47% for Q2 2026, up 18.84 percentage points from -37.31% a year earlier and up 4.80 percentage points from the prior quarter.
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Analysis
Spyre Therapeutics (SYRE) Return on Assets [ROA] (2016 - 2026) Analysis & Trends
For FY2025, Spyre Therapeutics' Return on Assets [ROA] was -22.39%, up 21.39 percentage points from FY2024.
- Return on Assets [ROA] carries a five-year change of +43.70 percentage points (FY2020 to FY2025).
- Going back by year, Return on Assets [ROA] was -43.78% in FY2024 (+120.28 pp), -164.06% in FY2023 (-71.48 pp), -92.58% in FY2022 (-44.11 pp) and -48.46% in FY2021 (+17.62 pp).
- The Q2 2026 figure represents the highest quarterly Return on Assets [ROA] in data going back to Q1 2016.
- Year-over-year, Return on Assets [ROA] has increased for ten consecutive quarters, with an average year-over-year change of +35.95 percentage points over the last eight quarters.
- The fastest year-over-year change in Return on Assets [ROA] over five years came in Q2 2024 (a gain of 143.90 percentage points), and the weakest in Q2 2023 (a drop of 92.00 percentage points).
- Business Quant data shows SYRE's Return on Assets [ROA] at -23.28% (Q1 2026), -24.21% (Q4 2025) and -28.55% (Q3 2025) in the three quarters before Q2 2026.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROA (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,076.25 Bn | 1,044.84 Bn | 19.71 Bn | 20.64% |
| 2 | Johnson & Johnson | 617.18 Bn | 535.70 Bn | 17.26 Bn | 10.47% |
| 3 | AbbVie | 464.58 Bn | 437.73 Bn | 12.70 Bn | 4.65% |
| 4 | Merck | 356.04 Bn | 310.47 Bn | 12.21 Bn | 2.45% |
| 5 | Novartis Ag | 269.07 Bn | 224.94 Bn | 11.24 Bn | 28.37% |
| 6 | Astrazeneca | 243.21 Bn | 216.77 Bn | 12.86 Bn | 9.10% |
| 7 | Amgen | 217.88 Bn | 173.28 Bn | 7.24 Bn | 9.29% |
| 8 | Gilead Sciences | 179.62 Bn | 153.74 Bn | 6.22 Bn | -6.13% |
| 9 | Pfizer | 158.45 Bn | 105.40 Bn | 10.94 Bn | 2.14% |
| 10 | Spyre Therapeutics | 8.21 Bn | 8.21 Bn | - | -18.47% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -18.47% |
| Mar 31, 2026 | -23.28% |
| Dec 31, 2025 | -24.21% |
| Sep 30, 2025 | -28.55% |
| Jun 30, 2025 | -37.31% |
| Mar 31, 2025 | -35.46% |
| Dec 31, 2024 | -40.41% |
| Sep 30, 2024 | -50.14% |
| Jun 30, 2024 | -40.27% |
| Mar 31, 2024 | -87.82% |
| Dec 31, 2023 | -123.39% |
| Sep 30, 2023 | -130.63% |
| Jun 30, 2023 | -184.17% |
| Mar 31, 2023 | -125.89% |
| Dec 31, 2022 | -103.02% |
| Sep 30, 2022 | -86.18% |
| Jun 30, 2022 | -92.18% |
| Mar 31, 2022 | -74.59% |
| Dec 31, 2021 | -55.04% |
| Sep 30, 2021 | -49.30% |
API Access
Spyre Therapeutics Return on Assets [ROA] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-assets-%5Broa%5D&ticker=SYRE&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-assets-[roa]", "ticker": "SYRE", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-assets-%5Broa%5D&ticker=SYRE&period=max&api_key=YOUR_API_KEY");
const data = await res.json();