Spyre Therapeutics (SYRE) Notes Payables (2023 - 2026)

Spyre Therapeutics (SYRE) posted Notes Payables of $50.3 million for Q1 2026, up 120.25% on a QoQ basis from $22.8 million in Q4 2025, and up 17.4% year-over-year from $42.8 million in Q1 2025.

Spyre Therapeutics (SYRE) Notes Payables (2023 - 2026) Analysis & Trends

Spyre Therapeutics' Notes Payables history runs 4 years deep, the most recent figure standing at $50.3 million for Q1 2026.

  • Quarterly Notes Payables rose 17.4% year-over-year to $50.3 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was $50.3 million (up 17.4% YoY) and the FY2025 annual result came in at $22.8 million, down 9.01% from the prior year.
  • Notes Payables was $50.3 million for Q1 2026 at Spyre Therapeutics, up from $22.8 million in the prior quarter.
  • Across five years, Notes Payables topped out at $59.9 million in Q2 2025 and bottomed at $1.4 million in Q4 2023.
  • A 4-year average of $22.6 million and a median of $21.8 million in 2023 frame the typical range for Notes Payables.
  • Annual changes were most pronounced in 2024 — Notes Payables slumped 87.31% — and 2025, when it jumped 2168.94%.
  • Spyre Therapeutics' Notes Payables stood at $1.4 million in 2023, then surged by 1704.32% to $25.1 million in 2024, then declined by 9.01% to $22.8 million in 2025, then jumped by 120.25% to $50.3 million in 2026.
  • Business Quant data shows SYRE's Notes Payables at $50.3 million in Q1 2026, $22.8 million in Q4 2025, and $11.0 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn -
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn
4 NuCana 279.75 Bn 279.75 Bn -
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn
7 Belite Bio 62.51 Bn 62.51 Bn -
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn
9 Revolution Medicines 37.78 Bn 37.78 Bn -
10 Spyre Therapeutics 257.83 Mn 257.83 Mn -

Historic Data

Download Data
DateValue
Mar 31, 2026 50.26 Mn
Dec 31, 2025 22.82 Mn
Sep 30, 2025 11.02 Mn
Jun 30, 2025 59.90 Mn
Mar 31, 2025 42.81 Mn
Dec 31, 2024 25.08 Mn
Sep 30, 2024 24.74 Mn
Jun 30, 2024 2.64 Mn
Mar 31, 2024 2.59 Mn
Dec 31, 2023 1.39 Mn
Sep 30, 2023 7.51 Mn
Jun 30, 2023 20.81 Mn