Spyre Therapeutics (SYRE) EPS (Diluted) (2020 - 2026)
Spyre Therapeutics' EPS (Diluted) was -$0.43 in Q2 2026, compared with -$0.61 a year earlier.
Powered by 
Analysis
Spyre Therapeutics (SYRE) EPS (Diluted) (2020 - 2026) Analysis & Trends
On a trailing twelve-month basis, Spyre Therapeutics' EPS (Diluted) was -$2.10 through Jun 30, 2026; for FY2025, it was -$2.42.
- In earlier years, EPS (Diluted) was -$4.38 in FY2024, -$46.15 in FY2023, -$24.86 in FY2022 and -$25.02 in FY2021.
- Quarterly EPS (Diluted) has moved between -$1,405 (Q2 2023) and -$0.19 (Q3 2025) over five years.
- Per Business Quant data, SYRE's EPS (Diluted) in the three quarters before Q2 2026 was -$0.87 (Q1 2026), -$0.98 (Q4 2025) and -$0.19 (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EPS (Diluted) (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 645.01 Bn | 563.54 Bn | 17.26 Bn | 2.27 |
| 2 | AbbVie | 465.23 Bn | 438.39 Bn | 12.70 Bn | 2.04 |
| 3 | Merck | 368.40 Bn | 322.83 Bn | 12.21 Bn | -0.54 |
| 4 | Novartis Ag | 278.02 Bn | 233.89 Bn | 11.24 Bn | 1.67 |
| 5 | Astrazeneca | 254.57 Bn | 228.13 Bn | 12.86 Bn | 1.85 |
| 6 | Amgen | 229.02 Bn | 184.42 Bn | 7.24 Bn | 4.37 |
| 7 | Gilead Sciences | 187.74 Bn | 161.85 Bn | 6.22 Bn | -8.44 |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | -0.04 |
| 9 | Vertex Pharmaceuticals | 133.45 Bn | 105.45 Bn | 2.84 Bn | 4.31 |
| 10 | Spyre Therapeutics | 7.46 Bn | 7.46 Bn | - | -0.43 |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -0.43 |
| Mar 31, 2026 | -0.87 |
| Dec 31, 2025 | -0.98 |
| Sep 30, 2025 | -0.19 |
| Jun 30, 2025 | -0.61 |
| Mar 31, 2025 | -0.74 |
| Dec 31, 2024 | -1.19 |
| Sep 30, 2024 | -1.35 |
| Jun 30, 2024 | -0.85 |
| Mar 31, 2024 | -1.18 |
| Dec 31, 2023 | -8.61 |
| Sep 30, 2023 | -7.49 |
| Jun 30, 2023 | -1,405.15 |
| Mar 31, 2023 | -4.89 |
| Dec 31, 2022 | -5.58 |
| Sep 30, 2022 | -4.84 |
| Jun 30, 2022 | -6.79 |
| Mar 31, 2022 | -9.26 |
| Dec 31, 2021 | -7.77 |
| Sep 30, 2021 | -7.72 |
API Access
Spyre Therapeutics EPS (Diluted) API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=eps-diluted&ticker=SYRE&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "eps-diluted", "ticker": "SYRE", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=eps-diluted&ticker=SYRE&period=max&api_key=YOUR_API_KEY");
const data = await res.json();