Spyre Therapeutics (SYRE) EBIT (2015 - 2026)
Spyre Therapeutics' EBIT came in at -$41.64 million for Q2 2026, compared with -$41.94 million a year earlier.
Powered by 
Analysis
Spyre Therapeutics (SYRE) EBIT (2015 - 2026) Analysis & Trends
Over the trailing twelve months to Jun 30, 2026, Spyre Therapeutics reported EBIT of -$201.34 million; for FY2025, it came in at -$209.56 million.
- Going back by year, EBIT was -$208.57 million in FY2024, -$242.3 million in FY2023, -$84.78 million in FY2022 and -$65.65 million in FY2021.
- The Q2 2026 figure represents the highest quarterly EBIT since Q3 2023.
- Business Quant data shows SYRE's EBIT at -$45.64 million (Q1 2026), -$57.17 million (Q4 2025) and -$56.89 million (Q3 2025) in the three quarters before Q2 2026.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBIT (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,165.22 Bn | 1,133.81 Bn | 19.71 Bn | 11.75 Bn |
| 2 | Johnson & Johnson | 646.28 Bn | 566.14 Bn | 17.30 Bn | 6.18 Bn |
| 3 | AbbVie | 503.17 Bn | 476.28 Bn | 12.70 Bn | 6.43 Bn |
| 4 | Merck | 365.23 Bn | 319.60 Bn | 12.21 Bn | -584.00 Mn |
| 5 | Novartis Ag | 302.66 Bn | 266.65 Bn | 11.24 Bn | 4.75 Bn |
| 6 | Astrazeneca | 267.39 Bn | 241.08 Bn | 12.86 Bn | 3.16 Bn |
| 7 | Amgen | 241.61 Bn | 197.01 Bn | 7.24 Bn | 3.51 Bn |
| 8 | Gilead Sciences | 194.67 Bn | 168.86 Bn | 6.22 Bn | -10.39 Bn |
| 9 | Pfizer | 172.91 Bn | 119.55 Bn | 10.94 Bn | 4.27 Bn |
| 10 | Spyre Therapeutics | 7.82 Bn | 4.69 Bn | - | -41.64 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -41.64 Mn |
| Mar 31, 2026 | -45.64 Mn |
| Dec 31, 2025 | -57.17 Mn |
| Sep 30, 2025 | -56.89 Mn |
| Jun 30, 2025 | -41.94 Mn |
| Mar 31, 2025 | -53.57 Mn |
| Dec 31, 2024 | -61.25 Mn |
| Sep 30, 2024 | -55.39 Mn |
| Jun 30, 2024 | -44.15 Mn |
| Mar 31, 2024 | -47.77 Mn |
| Dec 31, 2023 | -45.91 Mn |
| Sep 30, 2023 | -18.34 Mn |
| Jun 30, 2023 | -159.25 Mn |
| Mar 31, 2023 | -18.81 Mn |
| Dec 31, 2022 | -19.16 Mn |
| Sep 30, 2022 | -18.76 Mn |
| Jun 30, 2022 | -22.42 Mn |
| Mar 31, 2022 | -24.44 Mn |
| Dec 31, 2021 | -20.44 Mn |
| Sep 30, 2021 | -20.29 Mn |
API Access
Spyre Therapeutics EBIT API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebit&ticker=SYRE&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebit", "ticker": "SYRE", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebit&ticker=SYRE&period=max&api_key=YOUR_API_KEY");
const data = await res.json();