Spero Therapeutics (SPRO) Return on Capital Employed [ROCE] (2017 - 2026)
Spero Therapeutics' Return on Capital Employed [ROCE] was 12.69% in Q2 2026, up 117.29 percentage points from -104.59% a year earlier but down 10.40 percentage points from the prior quarter.
Powered by 
Analysis
Spero Therapeutics (SPRO) Return on Capital Employed [ROCE] (2017 - 2026) Analysis & Trends
For FY2025, Return on Capital Employed [ROCE] at Spero Therapeutics came in at 7.81%, up 83.13 percentage points from FY2024.
- Return on Capital Employed [ROCE] shows a five-year change of +76.34 percentage points (FY2020 to FY2025).
- In earlier years, Return on Capital Employed [ROCE] was -75.33% in FY2024 (-93.77 pp), 18.45% in FY2023 (+51.86 pp), -33.41% in FY2022 (+27.85 pp) and -61.26% in FY2021 (+7.27 pp).
- Quarterly Return on Capital Employed [ROCE] has moved between -199.94% (Q3 2022) and 23.10% (Q1 2026) over five years.
- Compared with a year earlier, Return on Capital Employed [ROCE] has increased for three straight quarters, with an average year-over-year change of -12.93 percentage points over the last eight quarters.
- The best year-over-year quarter for Return on Capital Employed [ROCE] over five years was Q3 2023 (a gain of 195.90 percentage points); the worst was Q3 2022 (a drop of 130.94 percentage points).
- Per Business Quant data, SPRO's Return on Capital Employed [ROCE] in the three quarters before Q2 2026 was 23.10% (Q1 2026), 11.99% (Q4 2025) and -105.22% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,230.11 Bn | 1,198.70 Bn | 19.71 Bn | 46.74% |
| 2 | Johnson & Johnson | 644.39 Bn | 564.25 Bn | 17.30 Bn | 17.52% |
| 3 | AbbVie | 503.52 Bn | 476.68 Bn | 12.70 Bn | 17.92% |
| 4 | Merck | 363.29 Bn | 317.72 Bn | 12.21 Bn | 6.28% |
| 5 | Novartis Ag | 298.23 Bn | 262.62 Bn | 11.24 Bn | 19.32% |
| 6 | Astrazeneca | 267.53 Bn | 241.29 Bn | 12.86 Bn | 16.76% |
| 7 | Amgen | 241.80 Bn | 197.20 Bn | 7.24 Bn | 16.66% |
| 8 | Gilead Sciences | 195.07 Bn | 169.19 Bn | 6.22 Bn | -5.97% |
| 9 | Pfizer | 173.33 Bn | 120.28 Bn | 10.94 Bn | 11.86% |
| 10 | Spero Therapeutics | 65.71 Mn | -130.08 Mn | - | 12.69% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 12.69% |
| Mar 31, 2026 | 23.10% |
| Dec 31, 2025 | 11.99% |
| Sep 30, 2025 | -105.22% |
| Jun 30, 2025 | -104.59% |
| Mar 31, 2025 | -114.07% |
| Dec 31, 2024 | -99.43% |
| Sep 30, 2024 | -1.18% |
| Jun 30, 2024 | 13.75% |
| Mar 31, 2024 | 16.31% |
| Dec 31, 2023 | 19.97% |
| Sep 30, 2023 | -4.03% |
| Jun 30, 2023 | -14.74% |
| Mar 31, 2023 | -27.40% |
| Dec 31, 2022 | -57.81% |
| Sep 30, 2022 | -199.94% |
| Jun 30, 2022 | -117.47% |
| Mar 31, 2022 | -110.67% |
| Dec 31, 2021 | -63.19% |
| Sep 30, 2021 | -69.00% |
API Access
Spero Therapeutics Return on Capital Employed [ROCE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=SPRO&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-capital-employed-[roce]", "ticker": "SPRO", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=SPRO&period=max&api_key=YOUR_API_KEY");
const data = await res.json();