SOPHiA GENETICS (SOPH) Operating Margin (2020 - 2026)
SOPHiA GENETICS's Operating Margin came in at -73.45% for Q3 2026, up 18.33 percentage points from -91.78% a year earlier and up 12.58 percentage points from the prior quarter.
Powered by 
Analysis
SOPHiA GENETICS (SOPH) Operating Margin (2020 - 2026) Analysis & Trends
Over the trailing twelve months to Sep 30, 2026, SOPHiA GENETICS reported Operating Margin of -80.99%, up 11.17 percentage points year-over-year; for FY2025, it came in at -91.76%, up 10.38 percentage points from FY2024.
- Operating Margin has increased in each of the last three years, with a five-year change of +39.88 percentage points (FY2020 to FY2025).
- Going back by year, Operating Margin was -102.14% in FY2024 (+17.83 pp), -119.97% in FY2023 (+64.69 pp), -184.66% in FY2022 (-7.92 pp) and -176.73% in FY2021 (-45.09 pp).
- The Q3 2026 figure represents the highest quarterly Operating Margin in data going back to Q2 2020.
- Year-over-year, Operating Margin has increased for five consecutive quarters, with an average year-over-year change of +10.72 percentage points over the last eight quarters.
- The fastest year-over-year change in Operating Margin over five years came in Q3 2023 (a gain of 101.47 percentage points), and the weakest in Q1 2022 (a drop of 73.80 percentage points).
- Business Quant data shows SOPH's Operating Margin at -86.03% (Q2 2026), -79.69% (Q1 2026) and -85.30% (Q4 2025) in the three quarters before Q3 2026.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Bryn | 945.00 Bn | 945.00 Bn | - | - |
| 2 | Veeva Systems | 49.39 Bn | 21.63 Bn | 695.95 Mn | 29.64% |
| 3 | Samsara | 23.96 Bn | 20.73 Bn | 392.58 Mn | 0.96% |
| 4 | Ptc | 22.37 Bn | 21.18 Bn | 490.47 Mn | 27.75% |
| 5 | Toast | 20.05 Bn | 12.69 Bn | 543.00 Mn | 8.33% |
| 6 | Manhattan Associates | 14.85 Bn | 13.91 Bn | 174.30 Mn | 26.45% |
| 7 | Bentley Systems | 13.89 Bn | 13.37 Bn | 349.55 Mn | 29.09% |
| 8 | Trimble | 12.57 Bn | 11.65 Bn | 659.10 Mn | 14.69% |
| 9 | Costar | 12.28 Bn | 7.66 Bn | 741.00 Mn | 8.82% |
| 10 | SOPHiA GENETICS | 482.23 Mn | 143.24 Mn | 15.93 Mn | -73.45% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Sep 30, 2026 | -73.45% |
| Jun 30, 2026 | -86.03% |
| Mar 31, 2026 | -79.69% |
| Dec 31, 2025 | -85.30% |
| Sep 30, 2025 | -91.78% |
| Jun 30, 2025 | -100.92% |
| Mar 31, 2025 | -90.20% |
| Dec 31, 2024 | -85.47% |
| Sep 30, 2024 | -96.91% |
| Jun 30, 2024 | -94.92% |
| Mar 31, 2024 | -118.87% |
| Dec 31, 2023 | -99.51% |
| Sep 30, 2023 | -101.48% |
| Jun 30, 2023 | -133.17% |
| Mar 31, 2023 | -138.10% |
| Dec 31, 2022 | -112.69% |
| Sep 30, 2022 | -202.94% |
| Jun 30, 2022 | -206.39% |
| Mar 31, 2022 | -230.37% |
| Dec 31, 2021 | -192.09% |
API Access
SOPHiA GENETICS Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=SOPH&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "SOPH", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=SOPH&period=max&api_key=YOUR_API_KEY");
const data = await res.json();