SOPHiA GENETICS (SOPH) Operating Margin (2020 - 2025)
SOPHiA GENETICS recorded quarterly Operating Margin of 85.3% in Q4 2025, up 7.06% quarter-over-quarter from 91.78% in Q3 2025, and up 1307.0% year-over-year from 6.06% in Q4 2024.
SOPHiA GENETICS's Operating Margin history runs 6 years deep, the most recent figure standing at 85.3% for Q4 2025.
- In Q4 2025, Operating Margin rose 1307.0% year-over-year to 85.3%; the TTM figure through Dec 2025 stood at 91.76% (up 1038.0% YoY), while the FY2025 annual figure was 91.76%, up 1038.0% from the prior year.
- Operating Margin came in at 85.3% for Q4 2025 at SOPHiA GENETICS, up from 91.78% in the prior quarter.
- In the past five years, Operating Margin ranged from a high of 85.3% in Q4 2025 to a low of 197914856.65% in Q3 2021.
- A 5-year average of 9895868.77% and a median of 115.78% in 2024 frame the typical range for Operating Margin.
- Across the five-year window, Operating Margin sank 2000000000 bps in 2021 and jumped 2000000000 bps in 2022, its largest moves.
- SOPHiA GENETICS's Operating Margin stood at 192.09% in 2021, then surged by 41 bps to 112.69% in 2022, then climbed by 1 bps to 111.13% in 2023, then rose by 11 bps to 98.37% in 2024, then grew by 13 bps to 85.3% in 2025.
- According to Business Quant data, Operating Margin over the past three periods registered 85.3%, 91.78%, and 100.92% for Q4 2025, Q3 2025, and Q2 2025 respectively.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Veeva Systems | 30.85 Bn | 24.28 Bn | 622.47 Mn | 29.41% |
| 2 | BrightSpring Health Services | 12.29 Bn | 11.41 Bn | 482.22 Mn | 3.36% |
| 3 | Healthequity | 7.80 Bn | 7.48 Bn | 256.31 Mn | 29.03% |
| 4 | Hinge Health | 4.82 Bn | 4.51 Bn | 154.23 Mn | 17.59% |
| 5 | Doximity | 4.21 Bn | 3.46 Bn | 125.97 Mn | 17.08% |
| 6 | Waystar Holding | 4.18 Bn | 4.03 Bn | 268.04 Mn | 25.64% |
| 7 | 10x Genomics | 3.78 Bn | 3.24 Bn | 106.18 Mn | -11.30% |
| 8 | Privia Health | 2.65 Bn | 2.28 Bn | 595.71 Mn | 1.23% |
| 9 | Omnicell | 1.95 Bn | 1.78 Bn | 140.36 Mn | 5.44% |
| 10 | SOPHiA GENETICS | 24.12 Mn | -46.17 Mn | 14.69 Mn | -85.30% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -85.30% |
| Sep 30, 2025 | -91.78% |
| Jun 30, 2025 | -100.92% |
| Mar 31, 2025 | -90.20% |
| Dec 31, 2024 | -98.37% |
| Sep 30, 2024 | -96.91% |
| Jun 30, 2024 | -94.92% |
| Mar 31, 2024 | -118.87% |
| Dec 31, 2023 | -111.13% |
| Sep 30, 2023 | -101.48% |
| Jun 30, 2023 | -133.17% |
| Mar 31, 2023 | -138.10% |
| Dec 31, 2022 | -112.69% |
| Sep 30, 2022 | -202.94% |
| Jun 30, 2022 | -206.39% |
| Mar 31, 2022 | -230.37% |
| Dec 31, 2021 | -192.09% |
| Sep 30, 2021 | -197.91% |
| Jun 30, 2021 | -156,455,099.23% |
| Mar 31, 2021 | -156.57% |
| Dec 31, 2020 | -144.06% |
| Sep 30, 2020 | -131.57% |
| Jun 30, 2020 | -119.00% |