SOPHiA GENETICS (SOPH) Operating Margin (2020 - 2025)
SOPHiA GENETICS (SOPH) reported Operating Margin of 85.3% for Q4 2025, up 1307.0% on a YoY basis from 6.06% in Q4 2024, and up 7.06% sequentially from 91.78% in Q3 2025.
SOPHiA GENETICS (SOPH) Operating Margin (2020 - 2025) Analysis & Trends
SOPHiA GENETICS (SOPH) has 6 years of Operating Margin data on file, last reported at 85.3% in Q4 2025.
- For the quarter ending Q4 2025, Operating Margin rose 1307.0% year-over-year to 85.3%; the trailing twelve-month figure through Dec 2025 stood at 91.76% (up 1038.0% YoY), and the FY2025 full-year result was 91.76%, up 1038.0% from the prior year.
- Operating Margin grew to 85.3% in Q4 2025, from 91.78% in the prior quarter.
- In the past five years, Operating Margin ranged from a high of 85.3% in Q4 2025 to a low of 230.37% in Q1 2022.
- A 5-year average of 135.83% and a median of 115.78% in 2024 frame the typical range for Operating Margin.
- Across the five-year window, Operating Margin plunged 19791 bps in 2021 and soared 10147 bps in 2023, its largest moves.
- Tracing SOPH's Operating Margin over 5 years: stood at 192.09% in 2021, then soared by 41 bps to 112.69% in 2022, then gained by 1 bps to 111.13% in 2023, then grew by 11 bps to 98.37% in 2024, then advanced by 13 bps to 85.3% in 2025.
- Business Quant data shows SOPH's Operating Margin at 85.3% in Q4 2025, 91.78% in Q3 2025, and 100.92% in Q2 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Veeva Systems | 31.83 Bn | 24.52 Bn | 662.02 Mn | 30.93% |
| 2 | BrightSpring Health Services | 14.58 Bn | 13.68 Bn | 482.22 Mn | 3.36% |
| 3 | Healthequity | 8.29 Bn | 8.02 Bn | 256.31 Mn | 29.03% |
| 4 | Hinge Health | 5.96 Bn | 5.65 Bn | 154.23 Mn | 17.59% |
| 5 | 10x Genomics | 5.79 Bn | 5.26 Bn | 106.18 Mn | -11.30% |
| 6 | MiniMed | 4.49 Bn | 4.19 Bn | 480.00 Mn | -11.11% |
| 7 | Waystar Holding | 4.49 Bn | 4.42 Bn | 216.84 Mn | 25.64% |
| 8 | Doximity | 3.98 Bn | 3.23 Bn | 125.97 Mn | 17.08% |
| 9 | Privia Health | 3.18 Bn | 2.76 Bn | - | 1.23% |
| 10 | SOPHiA GENETICS | 392.41 Mn | 322.12 Mn | 14.69 Mn | -85.30% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -85.30% |
| Sep 30, 2025 | -91.78% |
| Jun 30, 2025 | -100.92% |
| Mar 31, 2025 | -90.20% |
| Dec 31, 2024 | -98.37% |
| Sep 30, 2024 | -96.91% |
| Jun 30, 2024 | -94.92% |
| Mar 31, 2024 | -118.87% |
| Dec 31, 2023 | -111.13% |
| Sep 30, 2023 | -101.48% |
| Jun 30, 2023 | -133.17% |
| Mar 31, 2023 | -138.10% |
| Dec 31, 2022 | -112.69% |
| Sep 30, 2022 | -202.94% |
| Jun 30, 2022 | -206.39% |
| Mar 31, 2022 | -230.37% |
| Dec 31, 2021 | -192.09% |
| Sep 30, 2021 | -197.91% |
| Jun 30, 2021 | -156.46% |
| Mar 31, 2021 | -156.57% |