SOPHiA GENETICS (SOPH) Operating Margin (2020 - 2025)

SOPHiA GENETICS has disclosed Operating Margin across 6 years of filings, most recently posting 85.3% for Q4 2025.

• Operating Margin for Q4 2025 came in at 85.3%, up 1307.0% year-over-year; the trailing twelve-month figure through Dec 2025 was 91.76% (up 1038.0% YoY), and the FY2025 annual result was 91.76%, up 1038.0% from the prior year.
• Operating Margin came in at 85.3% for Q4 2025 at SOPHiA GENETICS, up from 91.78% in the prior quarter.
• In the past five years, Operating Margin ranged from a high of 85.3% in Q4 2025 to a low of 197914856.65% in Q3 2021.
• The 5-year median for Operating Margin is 115.78% (2024), against an average of 9895868.77%.
• Across the five-year window, Operating Margin slumped 2000000000 bps in 2021 and soared 2000000000 bps in 2022, its largest moves.
• SOPHiA GENETICS's Operating Margin stood at 192.09% in 2021, then jumped by 41 bps to 112.69% in 2022, then advanced by 1 bps to 111.13% in 2023, then increased by 11 bps to 98.37% in 2024, then climbed by 13 bps to 85.3% in 2025.
• The last three Operating Margin figures came in at 85.3% (Q4 2025), 91.78% (Q3 2025), and 100.92% (Q2 2025), per Business Quant data.