Septerna (SEPN) Net Margin (2023 - 2026)
Septerna's (SEPN) quarterly Net Margin came in at 32.59% in Q1 2026, up 977380.0% year-on-year from N/an in Q1 2025, and up 26.8% quarter-over-quarter from 44.52% in Q4 2025.
Septerna (SEPN) Net Margin (2023 - 2026) Analysis & Trends
Septerna's Net Margin history runs 4 years deep, the most recent figure standing at 32.59% for Q1 2026.
- On a quarterly basis, Net Margin rose 977380.0% year-over-year to 32.59% in Q1 2026; TTM through Mar 2026 was 49.89%, a 806945.0% increase from a year earlier, with the FY2025 full-year figure at 106.37%, up 657251.0% from the prior year.
- Net Margin climbed to 32.59% in Q1 2026 per SEPN's latest filing, from 44.52% in the prior quarter.
- Across five years, Net Margin topped out at 38.02% in Q3 2025 and bottomed at 33166.67% in Q3 2023.
- The 4-year median for Net Margin is 9749.06% (2024), against an average of 9973.46%.
- Across the five-year window, Net Margin surged 2150587 bps in 2024 and sank 1636984 bps in 2025, its largest moves.
- Year by year, Net Margin stood at 15383.9% in 2023, then jumped by 37 bps to 9749.06% in 2024, then surged by 100 bps to 44.52% in 2025, then increased by 27 bps to 32.59% in 2026.
- Per Business Quant, the three latest SEPN Net Margin figures stand at 32.59% (Q1 2026), 44.52% (Q4 2025), and 38.02% (Q3 2025).
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 15.02% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 34.53% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 20.17% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 30.33% |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | Septerna | 1.50 Bn | 1.50 Bn | - | -32.59% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -32.59% |
| Dec 31, 2025 | -44.52% |
| Sep 30, 2025 | 38.02% |
| Jun 30, 2025 | -20,872.27% |
| Mar 31, 2025 | -9,806.39% |
| Dec 31, 2024 | -9,749.06% |
| Sep 30, 2024 | -11,660.80% |
| Jun 30, 2024 | -4,502.43% |
| Mar 31, 2024 | -4,527.44% |
| Dec 31, 2023 | -15,383.90% |
| Sep 30, 2023 | -33,166.67% |