Septerna (SEPN) Net Margin (2023 - 2026)
Septerna's Net Margin was -48.73% in Q2 2026, up 20823.54 percentage points from -20872.27% a year earlier but down 16.17 percentage points from the prior quarter.
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Analysis
Septerna (SEPN) Net Margin (2023 - 2026) Analysis & Trends
On a trailing twelve-month basis, Septerna's Net Margin was -24.53% through Jun 30, 2026, up 12028.50 percentage points year-over-year; for FY2025, it came in at -106.42%, up 6572.47 percentage points from FY2024.
- In earlier years, Net Margin was -6678.88% in FY2024 (-9447.10 pp) and 2768.21% in FY2023.
- Quarterly Net Margin has moved between -33166.67% (Q3 2023) and 29571.19% (Q4 2023) over five years.
- Compared with a year earlier, Net Margin has increased for four straight quarters, with an average year-over-year change of +1552.10 percentage points over the last eight quarters.
- The best year-over-year quarter for Net Margin over five years was Q3 2024 (a gain of 21505.87 percentage points); the worst was Q4 2024 (a drop of 39320.24 percentage points).
- Per Business Quant data, SEPN's Net Margin in the three quarters before Q2 2026 was -32.56% (Q1 2026), -44.61% (Q4 2025) and 38.02% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 21.86% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 21.27% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -8.04% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 22.61% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 18.81% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 23.62% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -134.51% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | -1.65% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 32.99% |
| 10 | Septerna | 1.81 Bn | 1.81 Bn | - | -48.73% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -48.73% |
| Mar 31, 2026 | -32.56% |
| Dec 31, 2025 | -44.61% |
| Sep 30, 2025 | 38.02% |
| Jun 30, 2025 | -20,872.27% |
| Mar 31, 2025 | -9,806.39% |
| Dec 31, 2024 | -9,749.06% |
| Sep 30, 2024 | -11,660.80% |
| Jun 30, 2024 | -4,462.16% |
| Mar 31, 2024 | -4,447.00% |
| Dec 31, 2023 | 29,571.19% |
| Sep 30, 2023 | -33,166.67% |
API Access
Septerna Net Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=net-margin&ticker=SEPN&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "net-margin", "ticker": "SEPN", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=net-margin&ticker=SEPN&period=max&api_key=YOUR_API_KEY");
const data = await res.json();