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Cash Flow Statement
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Septerna (SEPN) Net Cash Flow (2023 - 2025)

Septerna (SEPN) has 3 years of Net Cash Flow data on record, last reported at -$199.3 million in Q4 2025.

  • For Q4 2025, Net Cash Flow fell 232.89% year-over-year to -$199.3 million; the TTM value through Dec 2025 reached -$117.5 million, down 257.13%, while the annual FY2025 figure was -$117.5 million, 178.47% down from the prior year.
  • Net Cash Flow reached -$199.3 million in Q4 2025 per SEPN's latest filing, down from $130.7 million in the prior quarter.
  • Across five years, Net Cash Flow topped out at $150.0 million in Q4 2024 and bottomed at -$199.3 million in Q4 2025.
  • Average Net Cash Flow over 3 years is -$5.9 million, with a median of -$20.7 million recorded in 2025.
  • Peak YoY movement for Net Cash Flow: surged 1594.16% in 2024, then plummeted 294.11% in 2025.
  • A 3-year view of Net Cash Flow shows it stood at -$10.0 million in 2023, then soared by 1594.16% to $150.0 million in 2024, then plummeted by 232.89% to -$199.3 million in 2025.
  • Per Business Quant database, its latest 3 readings for Net Cash Flow were -$199.3 million in Q4 2025, $130.7 million in Q3 2025, and -$20.7 million in Q2 2025.