Septerna (SEPN) Free Cash Flow (2023 - 2026)
Septerna (SEPN) recorded quarterly Free Cash Flow of -$26.5 million in Q1 2026, down 75.81% quarter-over-quarter from -$15.1 million in Q4 2025, and down 11.55% on a YoY basis from -$29.9 million in Q1 2025.
Septerna (SEPN) Free Cash Flow (2023 - 2026) Analysis & Trends
Septerna's Free Cash Flow history runs 4 years deep, the most recent figure standing at -$26.5 million for Q1 2026.
- In Q1 2026, Free Cash Flow fell 11.55% year-over-year to -$26.5 million; the TTM figure through Mar 2026 stood at $106.9 million (up 241.03% YoY), while the FY2025 annual figure was $109.7 million, up 257.63% from the prior year.
- Free Cash Flow was -$26.5 million for Q1 2026 at Septerna, down from -$15.1 million in the prior quarter.
- In the past five years, Free Cash Flow ranged from a high of $168.8 million in Q3 2025 to a low of -$26.5 million in Q1 2026.
- Historically, Free Cash Flow has averaged $359700.0 across 4 years, with a median of -$17.4 million in 2024.
- The sharpest annual moves came in 2024 and 2025: Free Cash Flow tumbled 114.93% in 2024, then soared 1070.53% in 2025.
- A 4-year view of Free Cash Flow shows it stood at -$10.0 million in 2023, then slumped by 114.93% to -$21.6 million in 2024, then surged by 30.21% to -$15.1 million in 2025, then tumbled by 75.81% to -$26.5 million in 2026.
- The last three Free Cash Flow figures came in at -$26.5 million (Q1 2026), -$15.1 million (Q4 2025), and $168.8 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Free Cash Flow (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | -1.67 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -12.20 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -2.49 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 1.29 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | 63,220.27 |
| 10 | Septerna | 1.62 Bn | 1.62 Bn | - | -26.47 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -26.47 Mn |
| Mar 31, 2026 | -26.47 Mn |
| Dec 31, 2025 | -15.05 Mn |
| Dec 31, 2025 | -15.05 Mn |
| Sep 30, 2025 | 168.79 Mn |
| Sep 30, 2025 | 168.79 Mn |
| Jun 30, 2025 | -20.35 Mn |
| Jun 30, 2025 | -20.35 Mn |
| Mar 31, 2025 | -23.73 Mn |
| Mar 31, 2025 | -23.73 Mn |
| Dec 31, 2024 | -21.57 Mn |
| Dec 31, 2024 | -21.57 Mn |
| Sep 30, 2024 | -17.39 Mn |
| Sep 30, 2024 | -17.39 Mn |
| Jun 30, 2024 | -13.14 Mn |
| Jun 30, 2024 | -13.14 Mn |
| Mar 31, 2024 | -17.48 Mn |
| Mar 31, 2024 | -17.48 Mn |
| Dec 31, 2023 | -10.04 Mn |
| Dec 31, 2023 | -10.04 Mn |