Septerna (SEPN) Free Cash Flow (2023 - 2026)

Septerna (SEPN) recorded quarterly Free Cash Flow of -$26.5 million in Q1 2026, down 75.81% quarter-over-quarter from -$15.1 million in Q4 2025, and down 11.55% on a YoY basis from -$29.9 million in Q1 2025.

Septerna (SEPN) Free Cash Flow (2023 - 2026) Analysis & Trends

Septerna's Free Cash Flow history runs 4 years deep, the most recent figure standing at -$26.5 million for Q1 2026.

  • In Q1 2026, Free Cash Flow fell 11.55% year-over-year to -$26.5 million; the TTM figure through Mar 2026 stood at $106.9 million (up 241.03% YoY), while the FY2025 annual figure was $109.7 million, up 257.63% from the prior year.
  • Free Cash Flow was -$26.5 million for Q1 2026 at Septerna, down from -$15.1 million in the prior quarter.
  • In the past five years, Free Cash Flow ranged from a high of $168.8 million in Q3 2025 to a low of -$26.5 million in Q1 2026.
  • Historically, Free Cash Flow has averaged $359700.0 across 4 years, with a median of -$17.4 million in 2024.
  • The sharpest annual moves came in 2024 and 2025: Free Cash Flow tumbled 114.93% in 2024, then soared 1070.53% in 2025.
  • A 4-year view of Free Cash Flow shows it stood at -$10.0 million in 2023, then slumped by 114.93% to -$21.6 million in 2024, then surged by 30.21% to -$15.1 million in 2025, then tumbled by 75.81% to -$26.5 million in 2026.
  • The last three Free Cash Flow figures came in at -$26.5 million (Q1 2026), -$15.1 million (Q4 2025), and $168.8 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Free Cash Flow (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -1.67 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -12.20 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -2.49 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.29 Bn
9 Abivax 91.96 Bn 91.96 Bn - 63,220.27
10 Septerna 1.62 Bn 1.62 Bn - -26.47 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -26.47 Mn
Mar 31, 2026 -26.47 Mn
Dec 31, 2025 -15.05 Mn
Dec 31, 2025 -15.05 Mn
Sep 30, 2025 168.79 Mn
Sep 30, 2025 168.79 Mn
Jun 30, 2025 -20.35 Mn
Jun 30, 2025 -20.35 Mn
Mar 31, 2025 -23.73 Mn
Mar 31, 2025 -23.73 Mn
Dec 31, 2024 -21.57 Mn
Dec 31, 2024 -21.57 Mn
Sep 30, 2024 -17.39 Mn
Sep 30, 2024 -17.39 Mn
Jun 30, 2024 -13.14 Mn
Jun 30, 2024 -13.14 Mn
Mar 31, 2024 -17.48 Mn
Mar 31, 2024 -17.48 Mn
Dec 31, 2023 -10.04 Mn
Dec 31, 2023 -10.04 Mn