Septerna (SEPN) Free Cash Flow (2023 - 2026)

Septerna's (SEPN) quarterly Free Cash Flow came in at -$26.5 million in Q1 2026, down 11.55% year-on-year from -$29.9 million in Q1 2025, and down 75.81% quarter-over-quarter from -$15.1 million in Q4 2025.

Septerna (SEPN) Free Cash Flow (2023 - 2026) Analysis & Trends

Septerna's Free Cash Flow history runs 4 years deep, the most recent figure standing at -$26.5 million for Q1 2026.

  • On a quarterly basis, Free Cash Flow fell 11.55% year-over-year to -$26.5 million in Q1 2026; TTM through Mar 2026 was $106.9 million, a 241.03% increase from a year earlier, with the FY2025 full-year figure at $109.7 million, up 257.63% from the prior year.
  • Free Cash Flow slipped to -$26.5 million in Q1 2026 per SEPN's latest filing, from -$15.1 million in the prior quarter.
  • Across five years, Free Cash Flow topped out at $168.8 million in Q3 2025 and bottomed at -$26.5 million in Q1 2026.
  • The 4-year median for Free Cash Flow is -$17.4 million (2024), against an average of $359700.0.
  • Across the five-year window, Free Cash Flow tumbled 114.93% in 2024 and surged 1070.53% in 2025, its largest moves.
  • Year by year, Free Cash Flow stood at -$10.0 million in 2023, then plunged by 114.93% to -$21.6 million in 2024, then surged by 30.21% to -$15.1 million in 2025, then sank by 75.81% to -$26.5 million in 2026.
  • Per Business Quant, the three latest SEPN Free Cash Flow figures stand at -$26.5 million (Q1 2026), -$15.1 million (Q4 2025), and $168.8 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Free Cash Flow (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -19.58 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 158.09 Mn
4 NuCana 279.75 Bn 279.75 Bn - -1.53 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 1.29 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 848.30 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn -
9 Revolution Medicines 37.78 Bn 37.78 Bn - -354.95 Mn
10 Septerna 1.50 Bn 1.50 Bn - -26.47 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -26.47 Mn
Mar 31, 2026 -26.47 Mn
Dec 31, 2025 -15.05 Mn
Dec 31, 2025 -15.05 Mn
Sep 30, 2025 168.79 Mn
Sep 30, 2025 168.79 Mn
Jun 30, 2025 -20.35 Mn
Jun 30, 2025 -20.35 Mn
Mar 31, 2025 -23.73 Mn
Mar 31, 2025 -23.73 Mn
Dec 31, 2024 -21.57 Mn
Dec 31, 2024 -21.57 Mn
Sep 30, 2024 -17.39 Mn
Sep 30, 2024 -17.39 Mn
Jun 30, 2024 -13.14 Mn
Jun 30, 2024 -13.14 Mn
Mar 31, 2024 -17.48 Mn
Mar 31, 2024 -17.48 Mn
Dec 31, 2023 -10.04 Mn
Dec 31, 2023 -10.04 Mn