Septerna (SEPN) Enterprise Value (2023 - 2026)

Septerna's (SEPN) quarterly Enterprise Value came in at -$347.4 million in Q1 2026, down 3.39% year-on-year from -$359.6 million in Q1 2025, and up 11.17% quarter-over-quarter from -$391.1 million in Q4 2025.

Septerna (SEPN) Enterprise Value (2023 - 2026) Analysis & Trends

Septerna's Enterprise Value history runs 4 years deep, the most recent figure standing at -$347.4 million for Q1 2026.

  • On a quarterly basis, Enterprise Value fell 3.39% year-over-year to -$347.4 million in Q1 2026; TTM through Mar 2026 was -$347.4 million, a 3.39% decrease from a year earlier, with the FY2025 full-year figure at -$391.1 million, down 11.45% from the prior year.
  • Enterprise Value advanced to -$347.4 million in Q1 2026 per SEPN's latest filing, from -$391.1 million in the prior quarter.
  • Across five years, Enterprise Value topped out at -$81.3 million in Q1 2024 and bottomed at -$474.3 million in Q3 2025.
  • The 4-year median for Enterprise Value is -$326.6 million (2025), against an average of -$250.6 million.
  • Across the five-year window, Enterprise Value tumbled 313.09% in 2025 and declined 3.39% in 2026, its largest moves.
  • Year by year, Enterprise Value stood at -$88.5 million in 2023, then sank by 296.6% to -$350.9 million in 2024, then declined by 11.45% to -$391.1 million in 2025, then gained by 11.17% to -$347.4 million in 2026.
  • Per Business Quant, the three latest SEPN Enterprise Value figures stand at -$347.4 million (Q1 2026), -$391.1 million (Q4 2025), and -$474.3 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Enterprise Value (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -283.54 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -61.40 Mn
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn -4.79 Bn
4 NuCana 279.75 Bn 279.75 Bn - -32.26 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn -7.25 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn -8.75 Bn
7 Belite Bio 62.51 Bn 62.51 Bn - -
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn -5.18 Bn
9 Revolution Medicines 37.78 Bn 37.78 Bn - -1.91 Bn
10 Septerna 1.50 Bn 1.50 Bn - -347.40 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -347.40 Mn
Dec 31, 2025 -391.09 Mn
Sep 30, 2025 -474.35 Mn
Jun 30, 2025 -326.56 Mn
Mar 31, 2025 -336.01 Mn
Dec 31, 2024 -350.92 Mn
Sep 30, 2024 -130.53 Mn
Jun 30, 2024 -131.17 Mn
Mar 31, 2024 -81.34 Mn
Dec 31, 2023 -88.48 Mn
Sep 30, 2023 -98.52 Mn