Septerna (SEPN) EBT Margin (2023 - 2026)
Septerna's EBT Margin came in at -45.09% for Q2 2026, up 20827.17 percentage points from -20872.27% a year earlier but down 13.80 percentage points from the prior quarter.
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Analysis
Septerna (SEPN) EBT Margin (2023 - 2026) Analysis & Trends
Over the trailing twelve months to Jun 30, 2026, Septerna reported EBT Margin of -23.17%, up 12070.63 percentage points year-over-year; for FY2025, it came in at -106.35%, up 6618.86 percentage points from FY2024.
- Going back by year, EBT Margin was -6725.21% in FY2024 (+25637.04 pp) and -32362.25% in FY2023.
- The five-year range for quarterly EBT Margin is -33166.67% (Q3 2023) to 38.02% (Q3 2025).
- Year-over-year, EBT Margin has increased for four consecutive quarters, with an average year-over-year change of +7179.85 percentage points over the last eight quarters.
- The fastest year-over-year change in EBT Margin over five years came in Q3 2024 (a gain of 21428.60 percentage points), and the weakest in Q2 2025 (a drop of 16399.30 percentage points).
- Business Quant data shows SEPN's EBT Margin at -31.29% (Q1 2026), -44.47% (Q4 2025) and 38.02% (Q3 2025) in the three quarters before Q2 2026.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 26.66% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 25.18% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -4.11% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 29.63% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 18.19% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 27.53% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -131.41% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | -4.34% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 41.75% |
| 10 | Septerna | 1.81 Bn | 1.81 Bn | - | -45.09% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -45.09% |
| Mar 31, 2026 | -31.29% |
| Dec 31, 2025 | -44.47% |
| Sep 30, 2025 | 38.02% |
| Jun 30, 2025 | -20,872.27% |
| Mar 31, 2025 | -9,806.39% |
| Dec 31, 2024 | -9,824.53% |
| Sep 30, 2024 | -11,738.07% |
| Jun 30, 2024 | -4,472.97% |
| Mar 31, 2024 | -4,498.11% |
| Dec 31, 2023 | -15,383.90% |
| Sep 30, 2023 | -33,166.67% |
API Access
Septerna EBT Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebt-margin&ticker=SEPN&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebt-margin", "ticker": "SEPN", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebt-margin&ticker=SEPN&period=max&api_key=YOUR_API_KEY");
const data = await res.json();