Septerna (SEPN) EBITDA Margin (2023 - 2026)
Septerna (SEPN) reported EBITDA Margin of -61.35% for Q2 2026, up 23949.57 percentage points from -24010.92% a year earlier but down 12.79 percentage points from the prior quarter.
Powered by 
Analysis
Septerna (SEPN) EBITDA Margin (2023 - 2026) Analysis & Trends
Over the twelve months ended Jun 30, 2026, Septerna's EBITDA Margin came in at -42.37%, up 13814.66 percentage points year-over-year; for FY2025, it was -145.14%, up 7242.95 percentage points from FY2024.
- By year, EBITDA Margin came in at -7388.09% in FY2024 (-9323.85 pp) and 1935.76% in FY2023.
- Five-year quarterly EBITDA Margin spans a low of -24010.92% in Q2 2025 and a high of 29288.14% in Q4 2023.
- Year over year, EBITDA Margin has now increased in each of the last four quarters, with an average year-over-year change of -1037.70 percentage points over the last seven quarters.
- Per Business Quant data, the three quarters before Q2 2026 came in at -48.56% (Q1 2026), -64.77% (Q4 2025) and 14.03% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 35.95% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 49.01% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | 6.02% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | - |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 33.11% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 46.01% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -124.26% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 39.16% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 39.10% |
| 10 | Septerna | 1.81 Bn | 1.81 Bn | - | -61.35% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -61.35% |
| Mar 31, 2026 | -48.56% |
| Dec 31, 2025 | -64.77% |
| Sep 30, 2025 | 14.03% |
| Jun 30, 2025 | -24,010.92% |
| Mar 31, 2025 | -11,649.77% |
| Dec 31, 2024 | -11,476.42% |
| Sep 30, 2024 | -12,605.68% |
| Jun 30, 2024 | -4,792.43% |
| Mar 31, 2024 | -4,786.75% |
| Dec 31, 2023 | 29,288.14% |
API Access
Septerna EBITDA Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebitda-margin&ticker=SEPN&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebitda-margin", "ticker": "SEPN", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebitda-margin&ticker=SEPN&period=max&api_key=YOUR_API_KEY");
const data = await res.json();