Septerna (SEPN) EBITDA Margin (2023 - 2026)
Septerna (SEPN) recorded quarterly EBITDA Margin of 37.07% in Q1 2026, down 121.28% quarter-over-quarter from 174.19% in Q4 2025, and up 970448.0% on a YoY basis from N/an in Q1 2025.
Septerna (SEPN) EBITDA Margin (2023 - 2026) Analysis & Trends
Septerna's EBITDA Margin history runs 4 years deep, the most recent figure standing at 37.07% for Q1 2026.
- In Q1 2026, EBITDA Margin rose 970448.0% year-over-year to 37.07%; the TTM figure through Mar 2026 stood at 21.74% (up 850004.0% YoY), while the FY2025 annual figure was 22.33%, up 749609.0% from the prior year.
- EBITDA Margin was 37.07% for Q1 2026 at Septerna, down from 174.19% in the prior quarter.
- In the past five years, EBITDA Margin ranged from a high of 29082.2% in Q4 2023 to a low of 33166.67% in Q3 2023.
- Historically, EBITDA Margin has averaged 6061.01% across 4 years, with a median of 4470.98% in 2024.
- Biggest YoY gain for EBITDA Margin was 2161042 bps in 2024; the steepest drop was 4074164 bps in 2024.
- A 4-year view of EBITDA Margin shows it stood at 29082.2% in 2023, then slumped by 140 bps to 11659.43% in 2024, then surged by 101 bps to 174.19% in 2025, then sank by 121 bps to 37.07% in 2026.
- The last three EBITDA Margin figures came in at 37.07% (Q1 2026), 174.19% (Q4 2025), and 38.95% (Q3 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 719,706.53 Bn | 719,706.50 Bn | - | - |
| 2 | Belite Bio | 55,800.00 Bn | 55,800.00 Bn | - | - |
| 3 | Quantum Biopharma | 18,182.30 Bn | 18,182.29 Bn | - | - |
| 4 | Legend Biotech | 3,154.00 Bn | 3,153.71 Bn | 242.10 Mn | -6.43% |
| 5 | Akari Therapeutics | 1,844.30 Bn | 1,844.29 Bn | - | - |
| 6 | Evaxion A | 1,567.96 Bn | 1,567.94 Bn | - | - |
| 7 | Psyence Biomedical | 251.43 Bn | 251.42 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 112.56 Bn | 105.31 Bn | 2.59 Bn | 38.10% |
| 9 | Abivax | 94.37 Bn | 94.37 Bn | - | - |
| 10 | Septerna | 1.37 Bn | 1.37 Bn | - | -37.07% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -37.07% |
| Dec 31, 2025 | 174.19% |
| Sep 30, 2025 | 38.95% |
| Jun 30, 2025 | -20,890.76% |
| Mar 31, 2025 | -9,741.55% |
| Dec 31, 2024 | -11,659.43% |
| Sep 30, 2024 | -11,556.25% |
| Jun 30, 2024 | -4,443.78% |
| Mar 31, 2024 | -4,470.98% |
| Dec 31, 2023 | 29,082.20% |
| Sep 30, 2023 | -33,166.67% |