Septerna (SEPN) EBITDA Margin (2023 - 2026)
Septerna's quarterly EBITDA Margin came in at 37.07% in Q1 2026, up 970448.0% year-on-year from N/an in Q1 2025, and down 121.28% quarter-over-quarter from 174.19% in Q4 2025.
Septerna has reported EBITDA Margin for 4 years, with the latest figure at 37.07% in Q1 2026.
- For the quarter ending Q1 2026, EBITDA Margin rose 970448.0% year-over-year to 37.07%; the trailing twelve-month figure through Mar 2026 stood at 21.74% (up 850004.0% YoY), and the FY2025 full-year result was 22.33%, up 749609.0% from the prior year.
- EBITDA Margin for Q1 2026 stood at 37.07%, down from 174.19% in the prior quarter.
- The five-year high for EBITDA Margin was 29082.2% in Q4 2023, with the low at 33166.67% in Q3 2023.
- Average EBITDA Margin over 4 years is 6061.01%, with a median of 4470.98% recorded in 2024.
- Peak annual rise in EBITDA Margin reached 2161042 bps in 2024, while the deepest fall reached 4074164 bps in 2024.
- Tracing SEPN's EBITDA Margin over 4 years: stood at 29082.2% in 2023, then sank by 140 bps to 11659.43% in 2024, then soared by 101 bps to 174.19% in 2025, then plunged by 121 bps to 37.07% in 2026.
- The last three EBITDA Margin figures came in at 37.07% (Q1 2026), 174.19% (Q4 2025), and 38.95% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | -6.43% |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 38.10% |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 18.35% |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 17.24% |
| 10 | Septerna | 1.34 Bn | 1.34 Bn | - | -37.07% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -37.07% |
| Dec 31, 2025 | 174.19% |
| Sep 30, 2025 | 38.95% |
| Jun 30, 2025 | -20,890.76% |
| Mar 31, 2025 | -9,741.55% |
| Dec 31, 2024 | -11,659.43% |
| Sep 30, 2024 | -11,556.25% |
| Jun 30, 2024 | -4,443.78% |
| Mar 31, 2024 | -4,470.98% |
| Dec 31, 2023 | 29,082.20% |
| Sep 30, 2023 | -33,166.67% |