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Asset Utilization RatioAssets AverageEBIT MarginEBITDA MarginEBT MarginEnterprise ValueEquity AverageEquity RatioFCF MarginInvested CapitalNet MarginOperating MarginReturn on AssetsReturn on Capital EmployedReturn on EquityReturn on Invested CapitalReturn on Sales

Septerna (SEPN) EBITDA Margin (2023 - 2025)

Septerna has reported EBITDA Margin over the past 3 years, most recently at 66.44% for Q4 2025.

  • Quarterly results put EBITDA Margin at 66.44% for Q4 2025, up 1159300.0% from a year ago — trailing twelve months through Dec 2025 was 117.18% (up 692208.0% YoY), and the annual figure for FY2025 was 148.63%, up 736979.0%.
  • EBITDA Margin for Q4 2025 was 66.44% at Septerna, down from 38.95% in the prior quarter.
  • Over the last five years, EBITDA Margin for SEPN hit a ceiling of 29082.2% in Q4 2023 and a floor of 33166.67% in Q3 2023.
  • Median EBITDA Margin over the past 3 years was 7106.27% (2024), compared with a mean of 6687.47%.
  • Peak annual rise in EBITDA Margin hit 2161042bps in 2024, while the deepest fall reached -4074164bps in 2024.
  • Septerna's EBITDA Margin stood at 29082.2% in 2023, then crashed by -140bps to 11659.43% in 2024, then surged by 99bps to 66.44% in 2025.
  • The last three reported values for EBITDA Margin were 66.44% (Q4 2025), 38.95% (Q3 2025), and 20890.76% (Q2 2025) per Business Quant data.