Septerna (SEPN) Change in Cash (2023 - 2026)

Septerna's quarterly Change in Cash came in at -$49.1 million in Q1 2026, down 74.48% year-on-year from -$192.4 million in Q1 2025, and up 75.35% quarter-over-quarter from -$199.3 million in Q4 2025.

Septerna has reported Change in Cash for 4 years, with the latest figure at -$49.1 million in Q1 2026.

  • For the quarter ending Q1 2026, Change in Cash fell 74.48% year-over-year to -$49.1 million; the trailing twelve-month figure through Mar 2026 stood at -$138.4 million (down 207.56% YoY), and the FY2025 full-year result was -$117.5 million, down 178.47% from the prior year.
  • Change in Cash for Q1 2026 stood at -$49.1 million, up from -$199.3 million in the prior quarter.
  • The five-year high for Change in Cash was $150.0 million in Q4 2024, with the low at -$199.3 million in Q4 2025.
  • Average Change in Cash over 4 years is -$2.7 million, with a median of -$15.4 million recorded in 2023.
  • Year-over-year, Change in Cash jumped 1594.16% in 2024 and sank 294.11% in 2025.
  • Tracing SEPN's Change in Cash over 4 years: stood at -$10.0 million in 2023, then jumped by 1594.16% to $150.0 million in 2024, then slumped by 232.89% to -$199.3 million in 2025, then soared by 75.35% to -$49.1 million in 2026.
  • The last three Change in Cash figures came in at -$49.1 million (Q1 2026), -$199.3 million (Q4 2025), and $130.7 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - 2.44 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn 623.00 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -2.44 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 417.10 Mn
7 Evaxion A 62.56 Bn 62.54 Bn - -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn -153.10 Mn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 53.61 Mn
10 Septerna 1.34 Bn 1.34 Bn - -49.12 Mn

Historic Data

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DateValue
Mar 31, 2026 -49.12 Mn
Dec 31, 2025 -199.27 Mn
Sep 30, 2025 130.68 Mn
Jun 30, 2025 -20.73 Mn
Mar 31, 2025 -28.15 Mn
Dec 31, 2024 149.95 Mn
Sep 30, 2024 -42.93 Mn
Jun 30, 2024 49.83 Mn
Mar 31, 2024 -7.14 Mn
Dec 31, 2023 -10.04 Mn