KPIs & Operating Metrics(New)
Growth Metrics

Schrodinger (SDGR) Gross Margin (2019 - 2026)

Schrodinger has reported Gross Margin over the past 7 years, most recently at 65.68% for Q4 2025.

  • For Q4 2025, Gross Margin fell 694.0% year-over-year to 65.68%; the TTM value through Dec 2025 reached 55.74%, down 791.0%, while the annual FY2025 figure was 55.74%, 791.0% down from the prior year.
  • Gross Margin for Q4 2025 was 65.68% at Schrodinger, up from 51.61% in the prior quarter.
  • Over five years, Gross Margin peaked at 77.64% in Q4 2023 and troughed at 37.24% in Q3 2021.
  • A 5-year average of 55.12% and a median of 51.94% in 2025 define the central range for Gross Margin.
  • Biggest five-year swings in Gross Margin: plummeted -2196bps in 2021 and later soared 2695bps in 2024.
  • Year by year, Gross Margin stood at 57.1% in 2021, then rose by 19bps to 68.09% in 2022, then grew by 14bps to 77.64% in 2023, then decreased by -6bps to 72.61% in 2024, then dropped by -10bps to 65.68% in 2025.
  • Business Quant data shows Gross Margin for SDGR at 65.68% in Q4 2025, 51.61% in Q3 2025, and 47.77% in Q2 2025.