Rhythm Pharmaceuticals (RYTM) Return on Sales [ROS] (2021 - 2026)
Rhythm Pharmaceuticals' Return on Sales [ROS] was -68.14% in Q2 2026, up 25.25 percentage points from -93.39% a year earlier and up 18.97 percentage points from the prior quarter.
Powered by 
Analysis
Rhythm Pharmaceuticals (RYTM) Return on Sales [ROS] (2021 - 2026) Analysis & Trends
On a trailing twelve-month basis, Rhythm Pharmaceuticals' Return on Sales [ROS] was -83.62% through Jun 30, 2026, up 29.91 percentage points year-over-year; for FY2025, it came in at -101.19%, up 102.84 percentage points from FY2024.
- Return on Sales [ROS] has now increased for four consecutive years, with a four-year change of +5290.66 percentage points (FY2021 to FY2025).
- In earlier years, Return on Sales [ROS] was -204.04% in FY2024 (+34.07 pp), -238.10% in FY2023 (+519.82 pp), -757.92% in FY2022 (+4633.93 pp) and -5391.85% in FY2021.
- The Q2 2026 figure marks the highest quarterly Return on Sales [ROS] in data going back to Q1 2021.
- Compared with a year earlier, Return on Sales [ROS] has increased for nine straight quarters, with an average year-over-year change of +87.93 percentage points over the last eight quarters.
- The best year-over-year quarter for Return on Sales [ROS] over five years was Q1 2022 (a gain of 94762.58 percentage points); the worst was Q1 2024 (a drop of 80.68 percentage points).
- Per Business Quant data, RYTM's Return on Sales [ROS] in the three quarters before Q2 2026 was -87.11% (Q1 2026), -82.20% (Q4 2025) and -102.64% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,076.25 Bn | 1,044.84 Bn | 19.71 Bn | 51.16% |
| 2 | Johnson & Johnson | 617.18 Bn | 535.70 Bn | 17.26 Bn | 28.21% |
| 3 | AbbVie | 464.58 Bn | 437.73 Bn | 12.70 Bn | 37.86% |
| 4 | Merck | 356.04 Bn | 310.47 Bn | 12.21 Bn | -3.52% |
| 5 | Novartis Ag | 269.07 Bn | 224.94 Bn | 11.24 Bn | 32.97% |
| 6 | Astrazeneca | 243.21 Bn | 216.77 Bn | 12.86 Bn | 20.57% |
| 7 | Amgen | 217.88 Bn | 173.28 Bn | 7.24 Bn | 34.95% |
| 8 | Gilead Sciences | 179.62 Bn | 153.74 Bn | 6.22 Bn | -133.21% |
| 9 | Pfizer | 158.45 Bn | 105.40 Bn | 10.94 Bn | 28.37% |
| 10 | Rhythm Pharmaceuticals | 6.39 Bn | 5.26 Bn | 62.32 Mn | -68.14% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -68.14% |
| Mar 31, 2026 | -87.11% |
| Dec 31, 2025 | -82.20% |
| Sep 30, 2025 | -102.64% |
| Jun 30, 2025 | -93.39% |
| Mar 31, 2025 | -143.73% |
| Dec 31, 2024 | -98.63% |
| Sep 30, 2024 | -131.98% |
| Jun 30, 2024 | -139.20% |
| Mar 31, 2024 | -538.71% |
| Dec 31, 2023 | -170.28% |
| Sep 30, 2023 | -195.31% |
| Jun 30, 2023 | -242.46% |
| Mar 31, 2023 | -458.03% |
| Dec 31, 2022 | -478.99% |
| Sep 30, 2022 | -916.60% |
| Jun 30, 2022 | -497.42% |
| Mar 31, 2022 | -3,517.42% |
| Dec 31, 2021 | -2,806.22% |
| Sep 30, 2021 | -4,303.50% |
API Access
Rhythm Pharmaceuticals Return on Sales [ROS] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=RYTM&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-sales-[ros]", "ticker": "RYTM", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=RYTM&period=max&api_key=YOUR_API_KEY");
const data = await res.json();