Rhythm Pharmaceuticals (RYTM) Return on Sales [ROS] (2021 - 2026)
Rhythm Pharmaceuticals' Return on Sales [ROS] was -42.63% in Q3 2026, up 60.02 percentage points from -102.64% a year earlier and up 25.51 percentage points from the prior quarter.
Rhythm Pharmaceuticals (RYTM) Return on Sales [ROS] (2021 - 2026) Analysis & Trends
On a trailing twelve-month basis, Rhythm Pharmaceuticals' Return on Sales [ROS] was -66.70% through Sep 30, 2026, up 40.12 percentage points year-over-year; for FY2025, it came in at -101.19%, up 102.84 percentage points from FY2024.
- Return on Sales [ROS] has now increased for four consecutive years, with a four-year change of +5290.66 percentage points (FY2021 to FY2025).
- In earlier years, Return on Sales [ROS] was -204.04% in FY2024 (+34.07 pp), -238.10% in FY2023 (+519.82 pp), -757.92% in FY2022 (+4633.93 pp) and -5391.85% in FY2021.
- The Q3 2026 figure marks the highest quarterly Return on Sales [ROS] in data going back to Q1 2021.
- Compared with a year earlier, Return on Sales [ROS] has increased for ten straight quarters, with an average year-over-year change of +87.51 percentage points over the last eight quarters.
- The best year-over-year quarter for Return on Sales [ROS] over five years was Q1 2022 (a gain of 94762.58 percentage points); the worst was Q1 2024 (a drop of 80.68 percentage points).
- Per Business Quant data, RYTM's Return on Sales [ROS] in the three quarters before Q3 2026 was -68.14% (Q2 2026), -87.11% (Q1 2026) and -82.20% (Q4 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,348.13 Bn | 1,321.74 Bn | 20.46 Bn | 34.46% |
| 2 | Johnson & Johnson | 675.90 Bn | 595.76 Bn | 17.30 Bn | 24.35% |
| 3 | AbbVie | 519.45 Bn | 487.50 Bn | 13.12 Bn | 36.01% |
| 4 | Merck | 364.95 Bn | 327.95 Bn | 13.19 Bn | 30.74% |
| 5 | Novartis Ag | 311.58 Bn | 285.16 Bn | - | - |
| 6 | Astrazeneca | 289.34 Bn | 262.94 Bn | 13.26 Bn | 29.12% |
| 7 | Amgen | 251.64 Bn | 203.30 Bn | 7.58 Bn | 35.79% |
| 8 | Gilead Sciences | 212.05 Bn | 187.07 Bn | 6.73 Bn | 41.71% |
| 9 | Pfizer | 167.35 Bn | 115.00 Bn | 12.56 Bn | 32.98% |
| 10 | Rhythm Pharmaceuticals | 7.90 Bn | 6.52 Bn | 79.96 Mn | -42.63% |
Historic Data
| Date | Value |
|---|---|
| Sep 30, 2026 | -42.63% |
| Jun 30, 2026 | -68.14% |
| Mar 31, 2026 | -87.11% |
| Dec 31, 2025 | -82.20% |
| Sep 30, 2025 | -102.64% |
| Jun 30, 2025 | -93.39% |
| Mar 31, 2025 | -143.73% |
| Dec 31, 2024 | -98.63% |
| Sep 30, 2024 | -131.98% |
| Jun 30, 2024 | -139.20% |
| Mar 31, 2024 | -538.71% |
| Dec 31, 2023 | -170.28% |
| Sep 30, 2023 | -195.31% |
| Jun 30, 2023 | -242.46% |
| Mar 31, 2023 | -458.03% |
| Dec 31, 2022 | -478.99% |
| Sep 30, 2022 | -916.60% |
| Jun 30, 2022 | -497.42% |
| Mar 31, 2022 | -3,517.42% |
| Dec 31, 2021 | -2,806.22% |
Rhythm Pharmaceuticals Return on Sales [ROS] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=RYTM&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-sales-[ros]", "ticker": "RYTM", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=RYTM&period=max&api_key=YOUR_API_KEY");
const data = await res.json();