Replimune (REPL) Return on Capital Employed (2018 - 2025)

Replimune's (REPL) quarterly Return on Capital Employed came in at 104.65% in Q4 2025, down 5673.0% year-on-year from 1.88% in Q4 2024, and down 23.13% quarter-over-quarter from 84.99% in Q3 2025.

Replimune (REPL) Return on Capital Employed (2018 - 2025) Analysis & Trends

Replimune has disclosed Return on Capital Employed across 8 years of filings, most recently posting 104.65% for Q4 2025.

  • Return on Capital Employed for Q4 2025 came in at 104.65%, down 5673.0% year-over-year; the trailing twelve-month figure through Dec 2025 was 104.65% (down 5673.0% YoY), and the FY2025 annual result was 57.23%, down 1266.0% from the prior year.
  • Return on Capital Employed came in at 104.65% for Q4 2025 at Replimune, down from 84.99% in the prior quarter.
  • In the past five years, Return on Capital Employed ranged from a high of 14.9% in Q1 2021 to a low of 104.65% in Q4 2025.
  • The 5-year median for Return on Capital Employed is 36.69% (2022), against an average of 42.08%.
  • Across the five-year window, Return on Capital Employed soared 949 bps in 2021 and plunged 5673 bps in 2025, its largest moves.
  • Replimune's Return on Capital Employed stood at 22.79% in 2021, then dropped by 29 bps to 29.4% in 2022, then plunged by 53 bps to 44.99% in 2023, then declined by 7 bps to 47.92% in 2024, then slumped by 118 bps to 104.65% in 2025.
  • The last three Return on Capital Employed figures came in at 104.65% (Q4 2025), 84.99% (Q3 2025), and 65.36% (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROCE (Qtr)
1 Alterity Therapeutics 762,369.55 Bn 762,369.51 Bn - -
2 Belite Bio 55,096.00 Bn 55,096.00 Bn - -
3 Quantum Biopharma 17,755.80 Bn 17,755.79 Bn - 450.31%
4 Legend Biotech 3,486.00 Bn 3,485.71 Bn 242.10 Mn 51.73%
5 Akari Therapeutics 1,737.42 Bn 1,737.41 Bn - -107.40%
6 Evaxion A 1,551.28 Bn 1,551.26 Bn - -
7 Psyence Biomedical 227.32 Bn 227.31 Bn - -
8 Vertex Pharmaceuticals 110.84 Bn 103.59 Bn 2.59 Bn 21.10%
9 Abivax 91.71 Bn 91.71 Bn - -50.43%
10 Replimune 780.01 Mn 510.88 Mn - -104.65%

Historic Data

Download Data
DateValue
Dec 31, 2025 -104.65%
Sep 30, 2025 -84.99%
Jun 30, 2025 -65.36%
Mar 31, 2025 -50.79%
Dec 31, 2024 -47.92%
Sep 30, 2024 -48.98%
Jun 30, 2024 -49.72%
Mar 31, 2024 -49.96%
Dec 31, 2023 -44.99%
Sep 30, 2023 -39.41%
Jun 30, 2023 -32.35%
Mar 31, 2023 -28.16%
Dec 31, 2022 -29.40%
Sep 30, 2022 -33.98%
Jun 30, 2022 -29.96%
Mar 31, 2022 -26.15%
Dec 31, 2021 -22.79%
Sep 30, 2021 -19.94%
Jun 30, 2021 -17.27%
Mar 31, 2021 -14.90%