Replimune (REPL) Free Cash Flow (2017 - 2025)

Replimune's (REPL) quarterly Free Cash Flow came in at -$66.1 million in Q4 2025, down 39.82% year-on-year from -$109.8 million in Q4 2024, and up 21.93% quarter-over-quarter from -$84.6 million in Q3 2025.

Replimune (REPL) Free Cash Flow (2017 - 2025) Analysis & Trends

Replimune has disclosed Free Cash Flow across 9 years of filings, most recently posting -$66.1 million for Q4 2025.

  • Free Cash Flow for Q4 2025 came in at -$66.1 million, down 39.82% year-over-year; the trailing twelve-month figure through Dec 2025 was -$288.5 million (down 51.43% YoY), and the FY2025 annual result was -$198.9 million, down 4.09% from the prior year.
  • Free Cash Flow came in at -$66.1 million for Q4 2025 at Replimune, up from -$84.6 million in the prior quarter.
  • In the past five years, Free Cash Flow ranged from a high of -$16.1 million in Q1 2021 to a low of -$84.6 million in Q3 2025.
  • The 5-year median for Free Cash Flow is -$42.9 million (2023), against an average of -$42.4 million.
  • Across the five-year window, Free Cash Flow increased 10.26% in 2024 and sank 107.87% in 2025, its largest moves.
  • Replimune's Free Cash Flow stood at -$18.8 million in 2021, then slumped by 44.28% to -$27.1 million in 2022, then tumbled by 65.96% to -$45.0 million in 2023, then decreased by 4.93% to -$47.3 million in 2024, then tumbled by 39.82% to -$66.1 million in 2025.
  • The last three Free Cash Flow figures came in at -$66.1 million (Q4 2025), -$84.6 million (Q3 2025), and -$77.7 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Free Cash Flow (Qtr)
1 Alterity Therapeutics 762,369.55 Bn 762,369.51 Bn - -
2 Belite Bio 55,096.00 Bn 55,096.00 Bn - -
3 Quantum Biopharma 17,755.80 Bn 17,755.79 Bn - -1.67 Mn
4 Legend Biotech 3,486.00 Bn 3,485.71 Bn 242.10 Mn -12.20 Mn
5 Akari Therapeutics 1,737.42 Bn 1,737.41 Bn - -2.49 Mn
6 Evaxion A 1,551.28 Bn 1,551.26 Bn - -
7 Psyence Biomedical 227.32 Bn 227.31 Bn - -
8 Vertex Pharmaceuticals 110.84 Bn 103.59 Bn 2.59 Bn 1.29 Bn
9 Abivax 91.71 Bn 91.71 Bn - 63,220.27
10 Replimune 780.01 Mn 510.88 Mn - -66.09 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -66.09 Mn
Dec 31, 2025 -66.09 Mn
Sep 30, 2025 -84.65 Mn
Sep 30, 2025 -84.65 Mn
Jun 30, 2025 -77.66 Mn
Jun 30, 2025 -77.66 Mn
Mar 31, 2025 -60.11 Mn
Mar 31, 2025 -60.11 Mn
Dec 31, 2024 -47.27 Mn
Dec 31, 2024 -47.27 Mn
Sep 30, 2024 -40.72 Mn
Sep 30, 2024 -40.72 Mn
Jun 30, 2024 -50.84 Mn
Jun 30, 2024 -50.84 Mn
Mar 31, 2024 -51.70 Mn
Mar 31, 2024 -51.70 Mn
Dec 31, 2023 -45.05 Mn
Dec 31, 2023 -45.05 Mn
Sep 30, 2023 -45.38 Mn
Sep 30, 2023 -45.38 Mn