Pyxis Oncology (PYXS) Net Income (2020 - 2025)

Pyxis Oncology's (PYXS) quarterly Net Income came in at -$18.4 million in Q4 2025, up 48.3% year-on-year from -$12.4 million in Q4 2024, and up 16.43% on a QoQ basis from -$22.0 million in Q3 2025.

Pyxis Oncology (PYXS) Net Income (2020 - 2025) Analysis & Trends

Pyxis Oncology (PYXS) has 6 years of Net Income data on file, last reported at -$18.4 million in Q4 2025.

  • On a quarterly basis, Net Income rose 48.3% year-over-year to -$18.4 million in Q4 2025; TTM through Dec 2025 was -$81.3 million, a 5.25% increase from a year earlier, with the FY2025 full-year figure at -$79.6 million, down 2.96% from the prior year.
  • Net Income for Q4 2025 stood at -$18.4 million, up from -$22.0 million in the prior quarter.
  • Over the last five years, Net Income for PYXS reached as high as -$5.9 million in Q2 2021 and fell as low as -$46.4 million in Q3 2021.
  • Historically, Net Income has averaged -$26.0 million across 5 years, with a median of -$23.3 million in 2023.
  • Across the five-year window, Net Income plunged 1353.15% in 2021 and jumped 54.22% in 2024, its largest moves.
  • Year by year, Net Income stood at -$32.8 million in 2021, then retreated by 8.01% to -$35.5 million in 2022, then jumped by 50.45% to -$17.6 million in 2023, then slumped by 102.42% to -$35.6 million in 2024, then jumped by 48.3% to -$18.4 million in 2025.
  • Per Business Quant data, the three most recent Net Income figures were -$18.4 million in Q4 2025, -$22.0 million in Q3 2025, and -$18.4 million in Q2 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Net Income (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -37.09 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 227.36 Mn
4 NuCana 279.75 Bn 279.75 Bn - -3.31 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 1.03 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 727.20 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -26.94 Mn
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn 362.00 Mn
9 Revolution Medicines 37.78 Bn 37.78 Bn - -453.82 Mn
10 Pyxis Oncology 166.54 Mn 99.69 Mn 8.65 Mn -18.39 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -18.39 Mn
Sep 30, 2025 -22.00 Mn
Jun 30, 2025 -18.35 Mn
Mar 31, 2025 -22.56 Mn
Dec 31, 2024 -35.57 Mn
Sep 30, 2024 -21.20 Mn
Jun 30, 2024 -17.30 Mn
Mar 31, 2024 -11.73 Mn
Dec 31, 2023 -17.57 Mn
Sep 30, 2023 -23.99 Mn
Jun 30, 2023 -17.90 Mn
Mar 31, 2023 -25.63 Mn
Dec 31, 2022 -35.46 Mn
Sep 30, 2022 -40.79 Mn
Jun 30, 2022 -39.05 Mn
Mar 31, 2022 -31.82 Mn
Dec 31, 2021 -32.83 Mn
Sep 30, 2021 -46.37 Mn
Jun 30, 2021 -5.94 Mn
Mar 31, 2021 -35.73 Mn