Protagonist Therapeutics (PTGX) Return on Sales (2017 - 2025)

Protagonist Therapeutics' Return on Sales history spans 9 years, with the latest figure at 6.03% for Q4 2025.

  • For Q4 2025, Return on Sales fell 683.0% year-over-year to 6.03%; the TTM value through Dec 2025 reached 2.84%, down 348.0%, while the annual FY2025 figure was 2.84%, 347.0% down from the prior year.
  • Return on Sales for Q4 2025 was 6.03% at Protagonist Therapeutics, up from 8.35% in the prior quarter.
  • Across five years, Return on Sales topped out at 10.32% in Q4 2021 and bottomed at 47.68% in Q2 2022.
  • The 5-year median for Return on Sales is 1.24% (2023), against an average of 4.7%.
  • The largest YoY upside for Return on Sales was 42124bps in 2021 against a maximum downside of -10654bps in 2021.
  • A 5-year view of Return on Sales shows it stood at 10.32% in 2021, then crashed by -103bps to 0.3% in 2022, then soared by 1069bps to 2.95% in 2023, then plummeted by -73bps to 0.8% in 2024, then crashed by -856bps to 6.03% in 2025.
  • Per Business Quant, the three most recent readings for PTGX's Return on Sales are 6.03% (Q4 2025), 8.35% (Q3 2025), and 6.27% (Q2 2025).